Research Programs

Cancer Therapeutics & Immuno-Oncology (CTI)

Program Leader: Duane Mitchell, M.D., Ph.D.


  1. Conduct first-in-human immunotherapy clinical trials for refractory malignancies
  2. Interrogate the role of host immune cells in tumor response and resistance to standard and experimental therapies
  3. Advance novel small molecule inhibitors of cancer through a preclinical to clinical development pathway


Cancer Genome & Epigenome Integrity (CGEI)

Program Leader: Robert Hromas, M.D., FACP


  1.  Connect DNA damage signaling with replication fork repair and restart
  2.  Dissect the role of chromosomal instability in oncogenesis
  3.  Define epigenetic mechanisms of treatment resistance and design methods to overcome barriers



Cancer Microbiota & Host Response (CMHR)

Program Leader: Christian Jobin, Ph.D.


  1. Mechanisms by which Novel therapeutic targets using preclinical and clinical models
  2. Microorganisms modulate cancer development
  3. Microorganisms acting as adjuvants in cancer therapy



Cancer Population Sciences (CPS)

Program Leader: Elizabeth Shenkman, Ph.D.


  1. Enhance patient-centered communication and shared decision-making across race/ethnic,socioeconomic, and geographic categories
  2. Improve health care quality and delivery through Implementation Science, Pragmatic Clinical Trials, and Clinical Research Informatics