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Cancer Genome & Epigenome Integrity

Mission

The University of Florida Health Cancer Center Cancer Genome and Epigenome Integrity (CGEI) research program is centered around gene expression, metabolism and cell proliferation.

Aims:

  •  Connect DNA damage signaling with replication fork repair and restart
  •  Dissect the role of chromosomal instability in oncogenesis
  •  Define epigenetic mechanisms of treatment resistance and design methods to overcome barriers

Program Leader

Robert A. Hromas, M.D., FACP, graduated from medical school at the University of Texas at Houston, where he was named an Outstanding Student in Internal Medicine. Dr. Hromas trained in blood cancers at the Fred Hutchinson Cancer Research Center with the Nobel Laureate Dr. Don Thomas and then joined the faculty at Indiana University Medical Center for 13 years before going to the University of New Mexico.

He is a leader in translating research into the discovery of new cancer drugs. A professor and chief of hematology-oncology at UNM, Dr. Hromas also was the deputy director of the UNM Cancer Center, the official cancer center of the state of New Mexico and one of only 66 National Cancer Institute-designated centers in the United States.

His background is in molecular genetics and DNA repair. He does drug design in silico, producing and screening cancer drug candidates through computer simulations. Dr. Hromas recently cloned and characterized several novel DNA repair proteins that play crucial roles in both chemotherapy resistance and in HIV integration. He has created new drugs that target these proteins and is testing them for effectiveness in treating cancers resistant to chemotherapy.

Dr. Hromas has held more than $8 million in cancer research grants and numerous national medical and scientific leadership positions. He has chaired grant review committees for the National Institutes of Health and for the American Cancer Society. He has served on the Lance Armstrong Foundation Scientific Board and has been elected to the American Society of Clinical Investigation and the Association of American Physicians. He has won multiple awards, including the Indiana University Board of Regents Teacher of the Year and the New Mexico People Caring Award.

Members

Baer, Charles F. PhD Assistant Professor BIOLOGY LIB ARTS / SCIENCES
Bungert, Jorg PhD Professor BIOCHEM / MOLECULAR BIOL MEDICINE
Concannon, Patrick PhD Director / Professor GENETICS INSTITUTE MEDICINE
Frost, Susan PhD Professor BIOCHEM / MOLECULAR BIOL MEDICINE
Guryanova, Olga MD, PhD Assistant Professor PHARMACOLOGY / THERAPEUTICS MEDICINE
Hromas, Robert MD Chair / Professor MEDICINE CHAIRMAN MEDICINE
Huang, Suming PhD Associate Professor BIOCHEM / MOLECULAR BIOL MEDICINE
Huang, Shuang PhD Professor ANATOMY MEDICINE
Ishov, Alexander M. PhD Associate Professor ANATOMY MEDICINE
Kilberg, Michael S. PhD Professor BIOCHEM / MOLECULAR BIOL MEDICINE
Kladde, Michael P. PhD Associate Professor BIOCHEMISTRY-GENERAL MEDICINE
Lele, Tanmay P. PhD Associate Professor CHEMICAL ENGINEERING ENGINEERING
Li, Chenglong PhD Professor MEDICINAL CHEMISTRY PHARMACY
Liang, Faming PhD Professor BIOSTATISTICS PHHP-COM INTEGRATED PROGRAMS
Liao, Daiqing PhD Associate Professor ANATOMY MEDICINE
Licht, Jonathan D. MD Director / Professor HEMATOLOGY/ONCOLOGY-ONCOL MEDICINE
Michailidis, George PhD Director / Professor INFORMATICS INSTITUTE OFFICE OF RESEARCH
Terada, Naohiro MD, PhD Professor PATHOLOGY MEDICINE
Wu, Lizi PhD Associate Professor MOLECULAR GENTCS / MICROBIO MEDICINE
Xie, Mingyi PhD Asstistant Professor BIOCHEM / MOLECULAR BIOL MEDICINE
Zhou, Lei BMed, PhD Associate Professor MOLECULAR GENTCS / MICROBIO MEDICINE