October Publications » Cancer Institute » UF Health Cancer Institute

Recent publications from the UF Health Cancer Institute.

Cancer Control and Population Sciences

Habib S, Perez Rodriguez Garcia G, Zhang Z, Roy A, Wu Y, Brito JP, Singh Ospina N. Determining Thyroid Biopsy Appropriateness: A Retrospective Study Integrating Clinical Context and Ultrasound Features. J Clin Endocrinol Metab. 2025 Oct 24:dgaf577. doi: 10.1210/clinem/dgaf577. Online ahead of print. PubMed PMID: 41133765.

Hong YR, Wang R, Carrier A, Ricks-Santi L, Kea T, Patel K, Virnig BA, Sahin I, Braithwaite D. Association between cancer screenings uptake and genetic testing for cancer risk among US adults: findings from HINTS 2017-2020. J Community Genet. 2025 Oct;16(5):545-556. doi: 10.1007/s12687-025-00797-0. Epub 2025 Apr 30. PubMed PMID: 40304964; PubMed Central PMCID: PMC12401849.

Prodigios J, Kundalia R, Acevedo A, Bontemps J, Pfaehler D, Hasan MMA, See KB, Verma N, Hochhegger D, Carvalho ARS, Mohammed TL, Hochhegger B. Quantitative Imaging Biomarkers in Lung Cancer: Current Trends and Future Directions. Semin Roentgenol. 2025 Oct;60(4):439-449. doi: 10.1053/j.ro.2025.06.002. Epub 2025 Jul 7. No abstract available. PubMed PMID: 41115741.

Verma N, Zanon M, Torri G, Hochhegger B. Low-dose CT for Lung Cancer Screening: Updates and Clinical Impact. Semin Roentgenol. 2025 Oct;60(4):357-364. doi: 10.1053/j.ro.2025.05.002. Epub 2025 Jun 14. No abstract available. PubMed PMID: 41115735.

Caldas de Lima JB, Griffin I, Gemmell JS, Davis K, Amanamba U, Zanjani NA, Siyanaki MRH, Mohammed TL, Benos T, Rodrigues RS, Manjarres DG, Sobhani A, Hochhegger B. Ethical, Regulatory, and Practical Challenges in Artificial Intelligence-Driven Chest Imaging. Semin Roentgenol. 2025 Oct;60(4):422-438. doi: 10.1053/j.ro.2025.06.003. Epub 2025 Jul 11. PubMed PMID: 41115740.

Shin B, Choi C, Dawson RJ, Kim CH, Bolch WE. Specific absorbed fractions and radionuclides values for adult and pediatric respiratory tracts within ICRP series of mesh-type reference computational phantoms. J Radiol Prot. 2025 Oct 28. doi: 10.1088/1361-6498/ae1843. Online ahead of print. PubMed PMID: 41151110.

Peng C, Zhang K, Lyu M, Liu H, Sun L, Wu Y. Scaling up biomedical vision-language models: Fine-tuning, instruction tuning, and multi-modal learning. J Biomed Inform. 2025 Oct 23;171:104946. doi: 10.1016/j.jbi.2025.104946. Online ahead of print. PubMed PMID: 41138953.

Rivero-Mendoza D, Gjoka K, Singh L, Adkins L, Bylund CL, Staras SAS, Salloum RG, Shenkman E, Egbounye NC, Mkuu RS. Health System Strategies to Improve the Uptake of Cervical Cancer Screening in Sub-Saharan Africa: A Scoping Systematic Review. Health Promot Pract. 2025 Oct 3:15248399251370668. doi: 10.1177/15248399251370668. Online ahead of print. PubMed PMID: 41044858.

Damera S, Lee JR, Hong YR, Nyame YA, Hammarlund N. Negative perceptions of the health system and racial inequities in PSA screening. Prostate Cancer Prostatic Dis. 2025 Oct 29. doi: 10.1038/s41391-025-01044-w. Online ahead of print. PubMed PMID: 41162557.

Choi C, Dawson RJ, Wang Y, Shin B, Tran-Gia J, Ramirez MS, Theisen AL, Lassmann M, Bolch WE. Mesh-based detailed skeletal models for the ICRP Reference Adults: Part 1. development and dosimetric impact. Phys Med Biol. 2025 Oct 24;70(21). doi: 10.1088/1361-6560/ae110f. PubMed PMID: 41061721.

Grippin AJ, Marconi C, Copling S, Li N, Braun C, Woody C, Young E, Gupta P, Wang M, Wu A, Jeong SD, Soni D, Weidert F, Xie C, Goldenberg E, Kim A, Zhao C, DeVries A, Castillo P, Lohray R, Rooney MK, Schrank BR, Wang Y, Ma Y, Chang E, Kouzy R, Dyson K, Jafarnia J, Nariman N, Gladish G, New J, Argueta A, Amaya D, Thomas N, Doty A, Chen J, Copling N, Alatrash G, Simon J, Davies AB, Dennis W, Liang R, Lewis J, Wei X, Rinsurongkawong W, Vaporciyan AA, Johns A; D3CODE Team; Lee J, Lee JH, Sun R, Sharma P, Tran H, Zhang J, Gibbons DL, Wargo J, Kim BYS, Heymach JV, Mendez-Gomez HR, Jiang W, Sayour EJ, Lin SH. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. Nature. 2025 Oct 22. doi: 10.1038/s41586-025-09655-y. Online ahead of print. PubMed PMID: 41125896.

Cogno N, Shah KD, Ehret F, Beekman C, Enderling H, Dawson RJ, Bolch WE, Shih HA, Paganetti H, Chamseddine I. A mechanistic model of brain necrosis progression based on vascular heterogeneity. Int J Radiat Oncol Biol Phys. 2025 Oct 11:S0360-3016(25)06332-1. doi: 10.1016/j.ijrobp.2025.09.059. Online ahead of print. PubMed PMID: 41083028.

Halle JL, Zhang Q, Baumfalk DR, Puppa MJ, Mohamed JS, Glazer ES, Smuder AJ, Alway SE, Carson JA. Sex impacts inflammatory signaling, body composition, and physical function in tumor-bearing mice receiving chemotherapy. Am J Physiol Cell Physiol. 2025 Oct 24. doi: 10.1152/ajpcell.00643.2025. Online ahead of print. PubMed PMID: 41134647.

Chang TY, Gou Q, Zhao L, Zhou T, Chen H, Yang D, Ju H, Smith KE, Sun C, Pan J, Huang Y, He X, Zhang X, Xu D, Xu J, Bian J, Chen A. From image to report: automating lung cancer screening interpretation and reporting with vision-language models. J Biomed Inform. 2025 Oct 11;171:104931. doi: 10.1016/j.jbi.2025.104931. Online ahead of print. PubMed PMID: 41083099; PubMed Central PMCID: PMC12579329.

Abbas M, Cruz CJ, Tamargo JA, Lipat AL, Fareed R, Deaton L, Gordon C, Johnson A, Sharma B, Leeuwenburgh C, Allen KD, Cruz-Almeida Y. Exploring senescence markers as potential drivers of osteoarthritis pain in aging adults. Exp Gerontol. 2025 Oct 30:112950. doi: 10.1016/j.exger.2025.112950. Online ahead of print. PubMed PMID: 41176294.

Nataliansyah MM, Lizarraga IM, Xing Y, Boughey JC, Snyder R, Mobley E. Disparity in Timely Breast Cancer Treatment: Concordance with Commission on Cancer Quality Measures and the Influence of Socioeconomic Factors in the National Cancer Database. J Am Coll Surg. 2025 Oct 6. doi: 10.1097/XCS.0000000000001649. Online ahead of print. PubMed PMID: 41100569.

Mensah ABB, Mensah KB, Agbeko AE, Nakua EK, Okyere J, Anane G, Baah JS, Nones M, Horvath KJ, Virnig B, Clegg-Lamptey JN, Kulasingam S. Anticipated First Contact and Time to Seek Healthcare for Possible Breast Cancer Symptoms: A Cross-Sectional Study in Rural Ghana. Health Expect. 2025 Oct;28(5):e70395. doi: 10.1111/hex.70395. PubMed PMID: 40874497; PubMed Central PMCID: PMC12392131.

Marchiori E, Hochhegger B, Zanetti G. Intrapulmonary lymph nodes. J Bras Pneumol. 2025 Oct 27;51(4):e20250278. doi: 10.36416/1806-3756/e20250278. No abstract available. PubMed PMID: 41172421.

Chen G, Xie Z, Sahin I, Zhu Y, Yoon HS, Turner K, Yang JJ, Hong YR. Examining Colorectal Cancer Treatment Patterns and Outcomes in Asian American, Native Hawaiian, and Pacific Islander Patients, 2007-2020. J Racial Ethn Health Disparities. 2025 Oct 20. doi: 10.1007/s40615-025-02713-1. Online ahead of print. PubMed PMID: 41114767.

Yan X, Lee JH, Lou XY. A regularized continuous-time hidden Markov model for identifying latent state transition patterns of poly-tobacco use. Biometrics. 2025 Oct 8;81(4):ujaf138. doi: 10.1093/biomtc/ujaf138. PubMed PMID: 41091654.

Kabbash M, Snider I, Neal D, Patel P, Pilecki M, Gonsalves C, Leon M, Dziegielewski P, Shaw CM, Shirali AS. Age, Not Frailty, Is Associated With Thyroidectomy of Indeterminate Thyroid Nodules. J Surg Res. 2025 Oct 23;315:741-746. doi: 10.1016/j.jss.2025.09.083. Online ahead of print. PubMed PMID: 41135324.

Cancer Targeting and Therapeutics

Pham THD, Chen M, Liu J, Chen QY, Seabra G, Paul VJ, Donia MS, Bruner SD, Ding Y, Luesch H. Biosynthesis, Chemical Synthesis, and Pharmacological Evaluation of Lyngbyapeptin A as a GPCR Antagonist of Motilin, Cannabinoid, and Amylin Receptors. J Nat Prod. 2025 Oct 17. doi: 10.1021/acs.jnatprod.5c00963. Online ahead of print. PubMed PMID: 41105455.

Thompson GR, Yu F, Han S (IOM), Tushoski-Aleman G, McKean JA, Hughes SJ, Shirali AS. Age-Associated Alterations in Cytokine and Extracellular Matrix Remodeling in the Papillary Thyroid Cancer Tumor Microenvironment. Ann Surg Oncol. 2025 Oct 13. doi: 10.1245/s10434-025-18473-5. Online ahead of print. PubMed PMID: 41083825.

Siemann DW, Horsman MR. Translating pre-clinical studies into the clinic: assays and endpoints selected to determine efficacy. Mol Cancer Ther. 2025 Oct 23. doi: 10.1158/1535-7163.MCT-25-0739. Online ahead of print. PubMed PMID: 41129734.

Rosales RDR, Venkatesh A, Kanumuambidi JP, Ishiyama Y, Al-Toubat M, Sceats H, Metzner TD, Sparks S, Murray N, Bandyk M, Balaji KC. Genetics-Driven, Intensity-Modulated Adaptive Management of Patients With Metastatic Prostate Cancer. Prostate. 2025 Oct 5. doi: 10.1002/pros.70070. Online ahead of print. PubMed PMID: 41046457.

Poddar SK, Dey K, Zheng G. Harnessing Chimeric Degrader Technologies for Antimicrobial Innovation. J Med Chem. 2025 Oct 23;68(20):20930-20963. doi: 10.1021/acs.jmedchem.5c01479. Epub 2025 Oct 13. PubMed PMID: 41084273.

Ng HK, Douglas CJ, Seath CP. microMap Photoproximity Labeling on the Cell Surface. Curr Protoc. 2025 Oct;5(10):e70216. doi: 10.1002/cpz1.70216. PubMed PMID: 41060711; PubMed Central PMCID: PMC12507076.

Liu D, Hsieh ML, Ding Y. Strategies for engineering domesticated and undomesticated human microbes. Curr Opin Biotechnol. 2025 Oct 4;96:103368. doi: 10.1016/j.copbio.2025.103368. Online ahead of print. PubMed PMID: 41046786.

Lin Z, Wu X, Mi K, Baynes RE, Tell LA, Riviere JE. Applications of PBPK Models to Predict Tissue Residues and Extralabel Withdrawal Times of Drugs in Food Animals: Perspectives from the Food Animal Residue Avoidance Databank (FARAD) Program. AAPS J. 2025 Oct 6;27(6):153. doi: 10.1208/s12248-025-01149-z. PubMed PMID: 41053499.

Mehta HJ, DiRico M, Vijayan K. Radiogenomics in Lung Cancer-Linking Imaging Phenotypes to Genetic Profiles. Semin Roentgenol. 2025 Oct;60(4):405-412. doi: 10.1053/j.ro.2025.05.001. Epub 2025 May 24. No abstract available. PubMed PMID: 41115738.

Pastorino A, Liu H, Pederson L, Martelli V, Iveson T, de Gramont A, Alberts SR, George TJ, Yothers G, Harkin A, Labianca R, Taieb J, Schmoll HJ, Twelves C, Wolmark N, Saltz LB, Souglakos I, Goldberg RM, Kerr R, Lonardi S, Yoshino T, Puccini A, Andre T, Shi Q, Sobrero A; ACCENT/IDEA Group. The Definition of Cure in Colon Cancer: A Pooled Analysis of 15 Randomized Clinical Trials. JAMA Oncol. 2025 Oct 2:e253760. doi: 10.1001/jamaoncol.2025.3760. Online ahead of print. PubMed PMID: 41037274; PubMed Central PMCID: PMC12492296.

Kang S, Huynh TH, Kim JM, Heo BE, Jang SC, Ock CW, Lee J, Song Y, An JS, Shen B, Kim SB, Jang J, Lee SK, Yoon YJ, Oh DC. Logical Exploration of Cinnamoyl-Containing Nonribosomal Peptides via Metabologenomic Targeting and Regulator Overexpression. J Am Chem Soc. 2025 Oct 15;147(41):37719-37731. doi: 10.1021/jacs.5c13143. Epub 2025 Oct 7. PubMed PMID: 41055158; PubMed Central PMCID: PMC12532209.

Hazard FK, Toland AMS, Tan SY, Chiu B, Ikegaki N, Naranjo A, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Reshmi SC, Wagner E, Nuchtern J, Asgharzadeh S, Marachelian A, Maris JM, Bagatell R, Park JR, Irwin MS, Hogarty MD, Shimada H. Sequential Combination of Unfavorable Histology followed by Clinical Stage M Defines High-Risk Neuroblastoma: A Report from the Children’s Oncology Group. Clin Cancer Res. 2025 Oct 27. doi: 10.1158/1078-0432.CCR-24-4369. Online ahead of print. PubMed PMID: 41143597.

Yasinzai AQK, Jalali P, Syaj S, Sahin IH, Nassour I, George TJ, Saeed A. Trends and Projected Burden of Early-Onset Gastrointestinal Malignancies in the United States: A Population-Based Analysis (2001-2021). J Natl Cancer Inst. 2025 Oct 17:djaf304. doi: 10.1093/jnci/djaf304. Online ahead of print. PubMed PMID: 41104650.

Selukar S, Clement H, Ni Y, Wu H, Patni T, Seffernick AE, Inaba H, Ribeiro R, Lamba J, Li Y, Pounds S. Interactive Use of Cox Model-Predicted Survival Curves: An Application Using ACS10 Score and Age to Personalize Treatment of Pediatric AML. JCO Precis Oncol. 2025 Oct;9:e2500634. doi: 10.1200/PO-25-00634. Epub 2025 Oct 2. PubMed PMID: 41037765; PubMed Central PMCID: PMC12506686.

Andrzejewski S, Winter M, Encarnacao Garcia L, Akinrinmade O, Madeira Marques F, Zacharioudakis E, Skwarska A, Aguirre-Ghiso J, Konopleva M, Zheng G, Fineberg SA, Zhou D, Gavathiotis E, Wang T, Dhimolea E. Quiescent OXPHOS-High Triple-Negative Breast Cancer Cells That Persist After Chemotherapy Depend on BCL-XL for Survival. Cells. 2025 Oct 8;14(19):1557. doi: 10.3390/cells14191557. PubMed PMID: 41090785; PubMed Central PMCID: PMC12524137.

Habib S, Perez Rodriguez Garcia G, Zhang Z, Roy A, Wu Y, Brito JP, Singh Ospina N. Determining Thyroid Biopsy Appropriateness: A Retrospective Study Integrating Clinical Context and Ultrasound Features. J Clin Endocrinol Metab. 2025 Oct 24:dgaf577. doi: 10.1210/clinem/dgaf577. Online ahead of print. PubMed PMID: 41133765.

Feri M, Kim SH, Cardenas FD, Anderson AM, Poole BT, Deshpande D, Desfor S, Atkinson KC, Peterson SR, Nettles KW, Nwachukwu JC, Ajayi MT, Beltran F, Martin DE, Tapia J, Curtis CD, Garcia-Castro MI, Katzenellenbogen BS, Katzenellenbogen JA, Tiwari-Woodruff SK. Chloroindazole based estrogen receptor beta ligands with favorable pharmacokinetics promote functional remyelination and visual recovery. Sci Rep. 2025 Oct 8;15(1):35056. doi: 10.1038/s41598-025-20254-9. PubMed PMID: 41062626; PubMed Central PMCID: PMC12508063.

Michel KA, Harlan CJ, Walker CM, Merritt ME, Chen Y, Lai SY, Bankson JA. Pharmacokinetic modeling strategies for dynamic hyperpolarized urea imaging. Magn Reson Med. 2025 Oct 12. doi: 10.1002/mrm.70117. Online ahead of print. PubMed PMID: 41077903.

Park J, Feldman E, Artz M, George J, Grewal H, Ho MW, Johnson P, Viviers E, Zhang Y. Automated Treatment Plan Integrity Verification for Proton Therapy: Enhancing Error Detection and Workflow Efficiency. Int J Part Ther. 2025 Oct 3;18:101207. doi: 10.1016/j.ijpt.2025.101207. eCollection 2025 Dec. PubMed PMID: 41142352; PubMed Central PMCID: PMC12553059.

Mahjabin F, Hajarat TJ, De Leo A, Nasri E, Gonsalves CA. A Rare Case of CIC-DUX4 Sarcoma in a Mediastinal Lymph Node Diagnosed by Fine Needle Aspiration Cytology. Diagn Cytopathol. 2025 Oct 29. doi: 10.1002/dc.70038. Online ahead of print. PubMed PMID: 41159260.

Immuno-Oncology and Microbiome

Ahmed M, Kee SL, Zaghloul N, Casanova NG, Rodriguez M, Kempf CL, Camp SM, Song JH, Sammani S, Gupta A, Bryant AJ, Ooi A, Desai AA, Makino A, Yuan JX, Benos PV, Dai Z, Garcia JGN. eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling. Cell Commun Signal. 2025 Oct 29;23(1):465. doi: 10.1186/s12964-025-02421-7. PubMed PMID: 41163035; PubMed Central PMCID: PMC12573901.

Shimano KA, Grimes AB, Kaicker S, Shah SJ, Gunn E, Bhat RV, Kochhar M, Rothman JA, Rose MJ, Briones M, Nakano TA, Lebensburger JD, Lambert MP, Fritch Lilla SA, Jesudas R, Lee-Miller CA, Thompson AA, Rifkin-Zenenberg S, Majumdar S, Crary SE, Hege K, Ford JB, Bies JJ, Fort J, Wynn TT, Hsieh L, Ruiz ME, Dinu B, Wong JMW, Kao PC, Kim TO, Arnold SD, Bennett CM, Despotovic JM, Klaassen RJ, Neufeld EJ, Neunert CE, London WB, Grace RF. Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial. JAMA. 2025 Oct 22:e2518168. doi: 10.1001/jama.2025.18168. Online ahead of print. PubMed PMID: 41123939; PubMed Central PMCID: PMC12547676.

Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska MA, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV. LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2025 Oct 9. doi: 10.1158/0008-5472.CAN-24-3239. Online ahead of print. PubMed PMID: 41066547.

Thompson GR, Yu F, Han S, Tushoski-Aleman G, McKean JA, Hughes SJ, Shirali AS. Age-Associated Alterations in Cytokine and Extracellular Matrix Remodeling in the Papillary Thyroid Cancer Tumor Microenvironment. Ann Surg Oncol. 2025 Oct 13. doi: 10.1245/s10434-025-18473-5. Online ahead of print. PubMed PMID: 41083825.

Diaz OE, Zhou L, Barrington C, Lindqvist D, Graelmann F, Wincent E, Stockinger B. Beneficial and detrimental consequences of AHR activation in intestinal infection. Life Sci Alliance. 2025 Oct 7;8(12):e202503414. doi: 10.26508/lsa.202503414. Print 2025 Dec. PubMed PMID: 41057229; PubMed Central PMCID: PMC12504769.

Thiessen R, Conte M, Stepien TL, Hillen T. Go-or-grow models in biology: a monster on a leash. J Math Biol. 2025 Oct 16;91(5):58. doi: 10.1007/s00285-025-02243-8. PubMed PMID: 41099842; PubMed Central PMCID: PMC12532697.

Osa-Andrews B, Ogunbileje JO, Harris N, Wynn T. A Case of Myelodysplastic Syndrome-Induced Acquired Sideroblastic Anemia. EJIFCC. 2025 Oct 1;36(3):402-406. eCollection 2025 Oct. PubMed PMID: 41098218; PubMed Central PMCID: PMC12519671.

Mechanisms of Oncogenesis

Pan Y, Wang Y, Wang G, Su J, Topaloglu U, Song Q. Large Language Models for Translational Cancer Informatics. JCO Clin Cancer Inform. 2025 Oct;9:e2500108. doi: 10.1200/CCI-25-00108. Epub 2025 Oct 14. PubMed PMID: 41086385.

Kovachka S, Wang J, Taghavi A, Jia Y, Asaba T, Wolff KC, Martin M, Yang X, Meyer SM, Ottilie S, Heacock M, Cheng Z, McNamara CW, Dubey G, Chatterjee AK, Chanda S, Gallego J, Childs-Disney JL, Disney MD. Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design. J Am Chem Soc. 2025 Oct 15;147(41):37460-37479. doi: 10.1021/jacs.5c11898. Epub 2025 Oct 6. PubMed PMID: 41051902; PubMed Central PMCID: PMC12532193.

Li C, Yang X, Dickerson KA, Zanon PRA, Springer NA, Wang J, Jia Y, Munshi NC, Batey RT, Disney MD. Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch. J Am Chem Soc. 2025 Oct 22;147(42):38684-38690. doi: 10.1021/jacs.5c13219. Epub 2025 Oct 7. PubMed PMID: 41056098; PubMed Central PMCID: PMC12550836.