November Publications » Cancer Institute » UF Health Cancer Institute

Recent publications from the UF Health Cancer Institute.

Cancer Control and Population Sciences

Alshammari RA, Tantawy M, Wang D, Castro-Hall E, Abreu M, Villa A, Katz J, Holliday LS, Gong Y. Integrative Epigenomic and Targeted Protein Analysis in MRONJ: Correlating DNA Methylation with Bone Biomarkers. Int J Mol Sci. 2025 Nov 20;26(22):11208. doi: 10.3390/ijms262211208. PubMed PMID: 41303691; PubMed Central PMCID: PMC12653879.

Verma H, Mistry S, Jayam KV, Shrestha P, Adkins L, Liang M, Fares A, Zarrinpar A, Braithwaite D, Karanth SD. Artificial Intelligence in Oncology: A 10-Year ClinicalTrials.gov-Based Analysis Across the Cancer Control Continuum. Cancers (Basel). 2025 Nov 1;17(21):3537. doi: 10.3390/cancers17213537. PubMed PMID: 41228330; PubMed Central PMCID: PMC12607805.

Salloum RG, Montague M, Minion M, LeLaurin JH, Lee JH, Ramly E, Liu G, Reid M, Bylund CL, McCarthy D, Shelley D, Ostroff JS, Warren GW. Sustainment of Tobacco Use Treatment Programs Across National Cancer Institute-Designated Cancer Centers. Cancer Med. 2025 Nov;14(22):e71424. doi: 10.1002/cam4.71424. PubMed PMID: 41294258; PubMed Central PMCID: PMC12648423.

Wollney EN, Bylund CL, Wright KB, Campbell-Salome G, Sae-Hau M, Weiss E, Bryan E, Nesbit TS, Fisher CL. The caregiver clinical communication process model: advancing the model to support spousal cancer caregivers. Support Care Cancer. 2025 Nov 13;33(12):1057. doi: 10.1007/s00520-025-10080-0. PubMed PMID: 41231249.

Bluck S, Koch MK, Yao Y, Crowe A, Cogdill-Richardson K, Chochinov HM, Wilkie D, Mroz EL, Kittelson S, Emanuel L, Bylund CL. Mechanisms of Dignity Therapy: Positive Outcomes in Older Cancer Patients. J Palliat Med. 2025 Nov 17. doi: 10.1177/10966218251399600. Online ahead of print. PubMed PMID: 41285488.

Smotherman C, Sprague BL, Braithwaite D, Yaghjyan L. Greenness and its interaction with air pollution in relation to postmenopausal breast cancer risk in UK Biobank. PLoS One. 2025 Nov 12;20(11):e0334744. doi: 10.1371/journal.pone.0334744. eCollection 2025. PubMed PMID: 41223176; PubMed Central PMCID: PMC12611134.

Shippee TP, Qin X, Vick R, Shippee ND, Parikh RR, Parsons HM, Virnig B. Underreporting of Pain for Short-Stay Nursing Home Residents in the Minimum Data Set 3.0?: Staff-Report, Self-Report, and the Role of Cognitive Impairment and Racial/Ethnic Identity. J Am Med Dir Assoc. 2025 Nov 14;27(1):105970. doi: 10.1016/j.jamda.2025.105970. Online ahead of print. PubMed PMID: 41198037.

Dawson RJ, Baggett JM, Dinwiddie LE, Smither WW, Wang Y, Wehmeier SK, Tran T, Pathak S, Domal SJ, Kofler C, Choi C, Yeom YS, Carter LM, Ocampo Ramos JC, Zanzonico PB, Kesner AL, Bolch WE. The UF/MSK adult mesh-based computational human phantom library: applications to organ dosimetry in computed tomography. Phys Med Biol. 2025 Nov 21;70(23). doi: 10.1088/1361-6560/ae1dc5. PubMed PMID: 41213257.

Carrera-Justiz S, Aghaee M, Qdaisat S, Weidert F, Garcia GA, Fagman L, Zhang D, Stover B, Moor RSF, Xie C, Goldenberg E, von Roemeling C, Doonan B, Chardon-Robles J, Elliott L, Sawyer WG, Deleyrolle LP, Sahay B, Foster TP, Seligson ND, Rahman M, Ghiaseddin A, Castillo P, Lee JH, Silver NL, Doty A, Ligon JA, Milner RJ, Mitchell D, Mendez-Gomez H, Moore H, Sayour EJ. Systemic mRNA vaccines elicit rapid immune activation in canine brain tumors. J Immunother Cancer. 2025 Nov 11;13(11):e011817. doi: 10.1136/jitc-2025-011817. PubMed PMID: 41218853; PubMed Central PMCID: PMC12606501.

Phuong HT, Tomas RF, Akmese C, Mijares A, Gerstin IM, Guo S, Bell LR, Ellwood R, Yegorova S, Ng SK, Massey G, Phillips J, Melloni A, Pletnikova O, Lou X, Clark HB, Troncoso JC, Hyman BT, Prokop S, Ranum LPW, Nguyen L. PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease. Acta Neuropathol. 2025 Nov 8;150(1):49. doi: 10.1007/s00401-025-02954-8. PubMed PMID: 41204969; PubMed Central PMCID: PMC12598690.

Wei YJ, Winterstein AG, Schmidt S, Fillingim RB, Daniels MJ, DeKosky ST, Schmidt S. Risk of Seizure Associated With Concomitant Use of Tramadol and Antidepressants in Older Nursing Home Residents. Neurology. 2025 Nov 11;105(9):e214270. doi: 10.1212/WNL.0000000000214270. Epub 2025 Oct 8. PubMed PMID: 41061201; PubMed Central PMCID: PMC12551759.

Wang Y, Guo Y, Tan AC, Zhao L, Shi X, Chen Y, Sun RC, Liu M, Su J, George TJ, Bian J, Song Q. A real-world cohort study of immune-related adverse events in patients receiving immune checkpoint inhibitors. NPJ Precis Oncol. 2025 Nov 11;9(1):346. doi: 10.1038/s41698-025-01123-0. PubMed PMID: 41219380; PubMed Central PMCID: PMC12606222.

Kim JH, Kim HJ, Suh HN, Kang MS, Kim IH, Park SW, Lee MH, Yoon HS, Han SM, Kim E, Meier J, Kim SH, Hyun M. Inhalation exposure to a tire-derived pollutant (6-PPD) triggers lung injury and mitochondrial dysfunction in mice. Ecotoxicol Environ Saf. 2025 Nov 24;307:119429. doi: 10.1016/j.ecoenv.2025.119429. Online ahead of print. PubMed PMID: 41289760.

Aung KZ, Zin SS, Wu X, Myint ZW, Karanth S, Estus S, Norris CM, Nelson PT, Fardo DW, Abner EL, Katsumata Y. Disentangling the inverse relationship between cancer and Alzheimer’s or Parkinson’s disease: A systematic review on Mendelian randomization studies. Neurobiol Dis. 2025 Nov 13;217:107190. doi: 10.1016/j.nbd.2025.107190. Online ahead of print. PubMed PMID: 41241298.

Roberson PNE, Brady KP, Thakur B, Booker S, Sola-Odeseye Z, Wood BL, Woods S. Family support as a pain protective factor for African American older adults: latent class analyses across 2 national longitudinal data sets. Pain. 2025 Nov 1;166(11):2588-2595. doi: 10.1097/j.pain.0000000000003687. Epub 2025 Jun 17. PubMed PMID: 41086308; PubMed Central PMCID: PMC12614246.

Soto Jacome C, Arce-Camposano A, Toro-Tobon D, Al Zahidy M, Rivadeneira F, Fierro FE, Montero M, Ponce O, Singh Ospina N, Brito JP. Drug Repurposing for Reducing the Size of Benign Thyroid Nodules: A Systematic Review. J Clin Endocrinol Metab. 2025 Nov 12:dgaf616. doi: 10.1210/clinem/dgaf616. Online ahead of print. PubMed PMID: 41225692.

Wang Y, Niu S, Doonan BP, Guha A, Fradley M, Wu Y, Smith SM, Gong Y, Song Q. Real-world analysis of cardiovascular adverse events and risk factors after immune checkpoint inhibitor therapy. Cardiooncology. 2025 Nov 17;11(1):107. doi: 10.1186/s40959-025-00406-6. PubMed PMID: 41250252; PubMed Central PMCID: PMC12625557.

Eduardo FP, Ferreira MH, Gobbi MF, Bergamin LG, Ferreira NG, Migliorati CA, Bezinelli LM, Arantes DCB. Impact of structured oral care strategies on oral mucositis in patients receiving 5-fluorouracil: a retrospective cohort study. Support Care Cancer. 2025 Nov 14;33(12):1065. doi: 10.1007/s00520-025-10079-7. PubMed PMID: 41239052.

Carr C, Collins SL, Zori G, King LM, Salinas-Miranda AA, Wilson RE, Scarborough K, Berry EL, Austin D, Briscoe R, King G, Cox L, Brown CYH, Best E, Burpee C, Allen-Mitchell A, Salihu HM. Community Members’ Perspectives on Men’s Risk and Protective Health Factors: A Community-Based Participatory Research Study. Community Health Equity Res Policy. 2025 Nov 27:2752535X251404211. doi: 10.1177/2752535X251404211. Online ahead of print. PubMed PMID: 41308186.

Cancer Targeting and Therapeutics

Thompson G, Yu F, Han S, Tushoski-Aleman G, McKean J, Hughes SJ, Shirali AS. ASO Visual Abstract: Age-Associated Alterations in Cytokine and Extracellular Matrix Remodeling in the Papillary Thyroid Cancer Tumor Microenvironment. Ann Surg Oncol. 2025 Nov 19. doi: 10.1245/s10434-025-18750-3. Online ahead of print. No abstract available. PubMed PMID: 41258982.

Norris ML, DeRemer DL, Duarte JD, Kim GP, George TJ. Severe toxicity following genotype-guided reduced 5-FU dose in a heterozygous DPYD c.2846A>T carrier with stage III anal carcinoma: A case report. Cancer Chemother Pharmacol. 2025 Nov 21;95(1):109. doi: 10.1007/s00280-025-04833-1. PubMed PMID: 41269318.

Ishiyama Y, Venkatesh A, Rodriguez Rosales RD, Kanumuambidi JP, Bandyk M, Balaji KC. Histology-Specific Survival in Penile Squamous Cell Carcinoma: A SEER-Based Study Highlighting Human Papillomavirus Status and Prognostic Subtypes. Cancers (Basel). 2025 Nov 20;17(22):3715. doi: 10.3390/cancers17223715. PubMed PMID: 41301078; PubMed Central PMCID: PMC12651401.

Siva Sankara C, Shanbhag AR, Rincon Diaz D, Hodges CA, Li C, Harrison JK, Zhang F. Engineering pH-Responsive Dendrimer-STAT3 Inhibitor Conjugates for Intracellular Delivery. Biomacromolecules. 2025 Nov 27. doi: 10.1021/acs.biomac.5c01648. Online ahead of print. PubMed PMID: 41307497.

Li H, Samia AM, Motaparthi K. Characterization of the spectrum of cutaneous adverse reactions to enfortumab vedotin: a retrospective cohort study. J Am Acad Dermatol. 2025 Nov 20:S0190-9622(25)03249-9. doi: 10.1016/j.jaad.2025.11.046. Online ahead of print. No abstract available. PubMed PMID: 41274570.

Salter B, Ge S, Garcia-Horton A, Berg T, Leber B, Walker I, Dalmia S, Radford M, Lepic K, Khalaf D. Real-world experience and outcomes of decitabine/cedazuridine or azacitidine for the treatment of myelodysplastic syndrome/chronic myelomonocytic leukemia. Leuk Lymphoma. 2025 Nov 5:1-8. doi: 10.1080/10428194.2025.2577861. Online ahead of print. No abstract available. PubMed PMID: 41194511.

Douglas CJ, Seath CP. DeSciDe: a tool for unbiased literature searching and gene list curation unveils a new role for the acidic patch mutation H2A E92K. Mol Omics. 2025 Nov 10. doi: 10.1039/d5mo00160a. Online ahead of print. PubMed PMID: 41212633; PubMed Central PMCID: PMC12599656.

Tang Z, Shan G. Adaptive sample size re-estimation designs for a two-stage randomized trial with binary outcome. Stat Methods Med Res. 2025 Nov 27:9622802251399914. doi: 10.1177/09622802251399914. Online ahead of print. PubMed PMID: 41308079.

Jackson AM, Shrestha DK, Johnson PB. Three-dimensional surface scanning of patients to extend computed tomography field of view and scan length for dose calculation and collision avoidance in radiotherapy treatment planning. J Appl Clin Med Phys. 2025 Nov;26(11):e70333. doi: 10.1002/acm2.70333. PubMed PMID: 41215563; PubMed Central PMCID: PMC12602972.

Mahadevan D, Barve M, Mahalingam D, Parekh J, Kurman M, Strauss J, Tremaine L, Hromas R, Sills J, McCulloch J, Harkey J, Suberg S, Zimmerman L, Zheng G, Zhou D. First in human phase 1 study of DT2216, a selective BCL-xL degrader, in patients with relapsed/refractory solid malignancies. J Hematol Oncol. 2025 Nov 12;18(1):98. doi: 10.1186/s13045-025-01753-8. PubMed PMID: 41225624; PubMed Central PMCID: PMC12613848.

Prasad R, Adu-Rutledge Y, Ziani B, Floyd JL, Ready EL, Paul S, Sheini F, Sharma R, Rosencrans RF, Li Calzi S, Sielski MS, Medawar NG, Dutta R, Johnson EB, Qi X, Bansal M, Lamendella R, Wright JR, Verma SK, Boulton ME, Stevens BR, Vander Kooi CW, Sun RC, Oudit GY, Li Q, Grant MB. Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach. Gut. 2025 Nov 5:gutjnl-2025-336180. doi: 10.1136/gutjnl-2025-336180. Online ahead of print. PubMed PMID: 41198173.

El-Khoueiry AB, Kim RD, Harris WP, Sung MW, Waldschmidt D, Cabrera R, Garosi VL, Ploeger BA, Zebger-Gong H, Brennan BJ, Wang YA, Mueller U, Weispfenning A, Seidel H, Coppieters S, Ishida TC, Galle PR. A multicenter dose-defining/expansion phase 1b study of first-line regorafenib plus pembrolizumab in patients with advanced hepatocellular carcinoma. Hepatology. 2025 Nov 10. doi: 10.1097/HEP.0000000000001585. Online ahead of print. PubMed PMID: 41213032.

Wang Y, Zhao C, Wang T, Steele A, Joshi M, Mori S, Chatterjee A, Shen B, Disney MD, Wasa M. Chemical Tagging of N-Alkylamine-Containing Natural Products and Pharmaceuticals through C(sp3)-H Functionalization. J Am Chem Soc. 2025 Nov 26;147(47):43424-43437. doi: 10.1021/jacs.5c11236. Epub 2025 Nov 14. PubMed PMID: 41238215.

Bird GH, Adhikary U, Schmidt MJ, Godes M, Tesar B, Camara CM, Paulo JA, Vidlak JF, DeAngelo TM, Marquez M, Gokhale P, Li R, Ho Sui SJ, Cameron MD, Gygi SP, Walensky LD. A triple-action PROTAC for wild-type p53 cancer therapy. Cell Rep Med. 2025 Nov 26:102467. doi: 10.1016/j.xcrm.2025.102467. Online ahead of print. PubMed PMID: 41308642.

Salem ME, Puccini A, Mauer E, Andre T, George TJ, Tabernero J, Sinicrope FA, Tie J, Kopetz S, Van Cutsem E, Lonardi S, Overman MJ, Foureau D. Impact of RAS/BRAF V600E mutations on the tumor immune microenvironment in mismatch repair deficient /microsatellite instability colorectal cancers. Clin Cancer Res. 2025 Nov 14. doi: 10.1158/1078-0432.CCR-25-2160. Online ahead of print. PubMed PMID: 41235954.

Ahmed SK, Binitie O, Krailo M, Indelicato DJ, Callan AK, DelRocco N, Buxton A, Chuba P, Christ A, Randall RL, Nadel H, Pawel B, Reed DR, Gorlick RG, DuBois SG, Janeway KA, Leavey PJ, Mascarenhas L, Laack NNI. Factors Associated with Primary Site Local Therapy in Patients with Non-Metastatic Ewing Sarcoma Treated with Interval Compressed Chemotherapy: A Report from the Children’s Oncology Group. Int J Radiat Oncol Biol Phys. 2025 Nov 22:S0360-3016(25)06476-4. doi: 10.1016/j.ijrobp.2025.11.010. Online ahead of print. PubMed PMID: 41285272.

Chopra A, He HZ, Milosevic J, Tirukkovalur N, Asmar RE, Nassour I, Nunns G, Chen M, Chen J, Jiang S, Singhi AD, Saeed A, Zhang J, Lee K, Zureikat A, Zheng SY, Paniccia A. KRAS Mutation Allele Frequency Dynamics in Plasma Extracellular Vesicles: Association with Survival in Localized Pancreatic Adenocarcinoma. Ann Surg Oncol. 2025 Nov 4. doi: 10.1245/s10434-025-18633-7. Online ahead of print. PubMed PMID: 41186643.

Shelton LM, Xu Y, Ghayee H, Buko AM. CBD Disrupts Malme-3M Cell Metabolism via Glycolytic Shift and Redox Imbalance. Curr Issues Mol Biol. 2025 Nov 6;47(11):928. doi: 10.3390/cimb47110928. PubMed PMID: 41296432; PubMed Central PMCID: PMC12651666.

Krommenhoek KB, Hol MLF, Slater O, Gaze MN, Fennis WMM, Kolb FJ, Smeele L, Indelicato DJ, Hoogeveen RC, Becking AG, Merks JHM. Dental Adverse Effects Following Multimodality Treatment for Head and Neck Rhabdomyosarcoma: Results of a Trans-Atlantic Multicentre Study. Pediatr Blood Cancer. 2025 Nov;72(11):e32004. doi: 10.1002/pbc.32004. Epub 2025 Sep 3. PubMed PMID: 40903911.

Esiashvili N, Indelicato DJ, Mahajan A, Parkes J, Paulino AC, Beljoudi G, Kristensen I, Laprie A, Lassen Y, Njiraini PN, Qureshi BM, Robles BG, Seiersen K, Timmermann B, Gaze MN. Selection of the Most Appropriate Radiation Treatment Modality for Children’s Cancers: A Paediatric Radiation Oncology Society (PROS) Position Paper on the Ethical Utilization of Proton Therapy. Pediatr Blood Cancer. 2025 Nov 20:e32155. doi: 10.1002/pbc.32155. Online ahead of print. PubMed PMID: 41261937.

Immuno-Oncology and Microbiome

Hamilton JS, Garg RR, Thomas RM. Dynasore as a dual modulator of lipid rafts and cell death in pancreatic cancer. Neoplasia. 2025 Nov 15;71:101254. doi: 10.1016/j.neo.2025.101254. Online ahead of print. PubMed PMID: 41242294; PubMed Central PMCID: PMC12664406.

Usher MR, Aybar-Torres AA, Jin L. Identification of common human TMEM173 genotypes associated with Alzheimer’s disease. J Alzheimers Dis. 2025 Nov 27:13872877251396973. doi: 10.1177/13872877251396973. Online ahead of print. PubMed PMID: 41308015.

Tushoski-Aleman GW, Maduro EA, Crespin AJ, McKean JA, Han S, Hughes SJ. Language barriers limit clinical trial accessibility for patients with gastrointestinal cancer. Gastroenterology. 2025 Nov 15:S0016-5085(25)06523-0. doi: 10.1053/j.gastro.2025.11.010. Online ahead of print. No abstract available. PubMed PMID: 41248864.

Thomas DM, Barrangou R, Kirkpatrick SI, Jablonski BBR, Madabhushi A, Tekwe CD, Hartshorn CM, Lemas DJ, Clark N, Powell M, Das SK. AI and Machine Learning in Nutrition: The Promise, the Challenge, and Recommendations. Am J Clin Nutr. 2025 Nov 26:101126. doi: 10.1016/j.ajcnut.2025.101126. Online ahead of print. No abstract available. PubMed PMID: 41314614.

Siva Sankara C, Shanbhag AR, Rincon Diaz D, Hodges CA, Li C, Harrison JK, Zhang F. Engineering pH-Responsive Dendrimer-STAT3 Inhibitor Conjugates for Intracellular Delivery. Biomacromolecules. 2025 Nov 27. doi: 10.1021/acs.biomac.5c01648. Online ahead of print. PubMed PMID: 41307497.

Mechanisms of Oncogenesis

Su X, Tong Y, Zanon PRA, Wang J, Tanaka T, Childs-Disney JL, Disney MD. Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for COL15A1 mRNA Degradation. J Am Chem Soc. 2025 Nov 26. doi: 10.1021/jacs.5c14363. Online ahead of print. PubMed PMID: 41297909.

McDougal DP, Pederick JL, Novick SJ, Jovcevski B, Warrender AK, Pascal BD, Griffin PR, Bruning JB. A ternary switch model governing ERalpha ligand binding domain conformation. Nat Commun. 2025 Nov 24;16(1):10363. doi: 10.1038/s41467-025-65323-9. PubMed PMID: 41285747; PubMed Central PMCID: PMC12644489.

Wang Y, Zhao C, Wang T, Steele A, Joshi M, Mori S, Chatterjee A, Shen B, Disney MD, Wasa M. Chemical Tagging of N-Alkylamine-Containing Natural Products and Pharmaceuticals through C(sp3)-H Functionalization. J Am Chem Soc. 2025 Nov 26;147(47):43424-43437. doi: 10.1021/jacs.5c11236. Epub 2025 Nov 14. PubMed PMID: 41238215.

Pala N, Ladu F, Szlasa W, Cadoni R, Lomelino C, Mahon BP, Gulkis M, McKenna R, Dessi A, Dallocchio R, Demelas A, Carcelli M, Rogolino D, Crosio C, Iaccarino C, Kulbacka J, Vullo D, Carta F, Supuran CT, Sechi M. Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore. Eur J Med Chem. 2025 Nov 15;298:118043. doi: 10.1016/j.ejmech.2025.118043. Epub 2025 Aug 5. PubMed PMID: 40782472.

Gaza J, Roth MJ, Montelione GT, Perez A. Hybrid AI/physics pipeline for miniprotein binder prioritization: application to the BRD3 ET domain. Chem Commun (Camb). 2025 Nov 27;61(96):19028-19031. doi: 10.1039/d5cc05032d. PubMed PMID: 41211640; PubMed Central PMCID: PMC12598730.

Fahmi NA, Cheng S, Overstreet J, Song Q, Yong J, Zhang W. IPScan: Detecting novel intronic PolyAdenylation events with RNA-seq data. PLoS Comput Biol. 2025 Nov 11;21(11):e1013668. doi: 10.1371/journal.pcbi.1013668. eCollection 2025 Nov. PubMed PMID: 41218079; PubMed Central PMCID: PMC12626307.

Mahmud I, Harmon TA, Meke LE, Garrett TJ. Discrepancies in Biomarker Identification in Peak Picking Strategies in Untargeted Metabolomics Analyses of Cells, Tissues, and Biofluids. J Proteome Res. 2025 Nov 20. doi: 10.1021/acs.jproteome.5c00434. Online ahead of print. PubMed PMID: 41263819.

Genutis LK, Villanueva P, Graze RM, AlHaj Abed J, McIntyre LM, Nuzhdin SV. Haplotype-resolved Chromatin Conformation Data reveals relationship between Transposable Elements and Chromosomal Pairing. Genome Biol Evol. 2025 Nov 26:evaf222. doi: 10.1093/gbe/evaf222. Online ahead of print. PubMed PMID: 41293827.