December Publications » Cancer Institute » UF Health Cancer Institute

Recent publications from the UF Health Cancer Institute.

Cancer Control and Population Sciences

Aduse-Poku L, Yaghjyan L, Kimmel SE, Datta S, Karanth SD, Yang JJ, Washington C, Braithwaite D. MRI-Derived Body Composition and Breast Cancer Risk in Postmenopausal Women: UK Biobank Study. Cancers (Basel). 2025 Dec 18;17(24):4036. doi: 10.3390/cancers17244036. PubMed PMID: 41463284; PubMed Central PMCID: PMC12731068.

Mkuu RS, Tohme S, Rivero-Mendoza D, Salloum RG, Goede D, Bruggeman B, Nicholson K, Hall JM, Bylund C, Woodard JN, Hensley J, Shenkman EA, Donahoo WT, Mulugeta A, Hernandez M, Staras SA. Improving Patient Education Materials for HPV Self-Collection: Insights from Women at High Risk of Developing Cervical Cancer. Cancer Manag Res. 2025 Dec 24;17:3273-3284. doi: 10.2147/CMAR.S552282. eCollection 2025. PubMed PMID: 41467104; PubMed Central PMCID: PMC12744586.

Wingard JR, Lee JH, Li D, Al-Mansour Z, Farhadfar N, Hsu J, Hiemenz J, Dean EA, Brown R, Trikha G, Schulz JN, Cline CL, Leather H, Sugrue MW, Dahl WJ, McGee KH, Leggett A, Kelly DL. Randomized Noninferiority Trial of a Liberalized Diet Versus the Neutropenic Diet in Hematopoietic Stem-Cell Transplant Patients and Patients With Acute Leukemia. J Clin Oncol. 2025 Dec 17:JCO2500889. doi: 10.1200/JCO-25-00889. Online ahead of print. PubMed PMID: 41406403.

Bertani S, Forte GC, Andrade RGF, Mehta H, da Fonseca JM, Marchiori E, Carvalho AR, Rodrigues RS, Hochhegger B. Opportunistic Lung Cancer Screening during Coronary Artery Calcium Scoring and CT Angiography. Radiol Cardiothorac Imaging. 2025 Dec;7(6):e250086. doi: 10.1148/ryct.250086. PubMed PMID: 41263660.

Emmi M, Filion M, Yao Y, Schwartz AL, Wilkie DJ, Yoon SL. Not All Cancer Survivors Respond to a 4-Week mHealth Exercise Fatigue Intervention: Who Are the Responders? Curr Oncol. 2025 Dec 15;32(12):706. doi: 10.3390/curroncol32120706. PubMed PMID: 41440234; PubMed Central PMCID: PMC12731583.

Kundalia R, Gemmell J, Griffin I, Acevedo A, Prodigios J, Bertani S, Carvalho ARS, Rodrigues RS, Mehta HJ, Hochhegger B. Magnetic Resonance of Pulmonary Nodules in Oncological Patients: Are We Ready to Replace Chest CT in Detecting Extrathoracic Cancer? Curr Oncol. 2025 Dec 16;32(12):710. doi: 10.3390/curroncol32120710. PubMed PMID: 41440238; PubMed Central PMCID: PMC12731333.

Modjarrad LS, Hall JM, Kates FR, Cogle CR, Ostbye R, Marlow NM, LeLaurin JH. Exploring the association between supportive school policy and youth tobacco use. Public Health. 2025 Dec 10;251:106083. doi: 10.1016/j.puhe.2025.106083. Online ahead of print. PubMed PMID: 41380368.

Mayya V, Vu GT, Mandhidi B, King C, Gurupur V, Little B, Singhal A. [Formula: see text] : explainable attentive transformers for identifying the factors influencing dental visits to enhance dental data completeness. BMC Oral Health. 2025 Dec 17;25(1):1913. doi: 10.1186/s12903-025-07170-0. PubMed PMID: 41408249; PubMed Central PMCID: PMC12713237.

Forsmark CE, Pandol S. The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) 10 years of past accomplishments and looking forward to the next 5 years of the Chronic Pancreatitis Clinical Research Consortium (CPCRC). Pancreatology. 2025 Dec 29:S1424-3903(25)00731-8. doi: 10.1016/j.pan.2025.12.023. Online ahead of print. No abstract available. PubMed PMID: 41484000.

Bruno KA, Wright RS, Culberson J, Wieczorek MA, Hodge DO, Johnson PW, Jimenez YA, Whelan ER, Malavet JM, Larson KF, Senefeld JW, Wiggins CC, Klassen SA, Ricci J, Sher T, Carter RE, Joyner MJ, Fairweather D, Jaffe AS. Cardiac troponin T elevation predicts mortality in hospitalized COVID-19 patients. Am Heart J Plus. 2025 Dec 2;61:100690. doi: 10.1016/j.ahjo.2025.100690. eCollection 2026 Jan. PubMed PMID: 41446701; PubMed Central PMCID: PMC12723113.

Liang J, Samper-Ternent R, Downer B, Xie Z. Associations between Caregiver-Provider Communication Quality and Unmet Care Needs Among Older Adults. Res Sq [Preprint]. 2025 Dec 2:rs.3.rs-7761669. doi: 10.21203/rs.3.rs-7761669/v1. PubMed PMID: 41377982; PubMed Central PMCID: PMC12687844.

Slomovitz BM, Weroha SJ, Deng W, Chon HS, Podder V, Jenkins Vogel MT, Backes F, Thomas ED, Chen LM, Tenney ME, Westin SN, Markham MJ, Miller DS, Edelson MI, Muller CY, Callahan MJ, Holman LL, Liu JR, Teplinsky E, Kamat A, Guy M, Chern JY, Lea J, Murphy M, Choong GM, Moore ED, Alvarez EA, Rodgers WH, O’Malley DM, Copeland LJ, Herzog TJ, Coleman RL, Gershenson DM. Phase II Trial of Ribociclib Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum: A GOG Partners Trial (GOG 3026). J Clin Oncol. 2025 Dec 12:JCO2501348. doi: 10.1200/JCO-25-01348. Online ahead of print. PubMed PMID: 41385758.

Park MA, Davis EW, Alhassan S, Arnoletti JP, Basinski TL, McKee AB, Bloomston M, Carson TL, Biachi de Castria T, Chen DT, Cortizas EM, Crowder SL, Delgado MG, Douglas WG, Fleming JB, Hodul P, Huguet KL, Jiang K, Kim DW, Koomen J, Luthra AK, Malafa M, Menon AA, Morales R, Merchant NB, Meredith K, Mo Q, Molina-Vega MA, Moreno-Urazan L, Olumoyin KD, Parker N, Pimiento JM, Rasool G, Rejniak KA, Sansil S, Sparks LM, Stewart P, Tassielli AF, Teer JK, Tran DV, Trevino JG, Velanovich V, Whelan CJ, Jeong D, Judge SM, Judge AR, Permuth JB. Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma. Commun Med (Lond). 2025 Dec 18. doi: 10.1038/s43856-025-01277-9. Online ahead of print. PubMed PMID: 41413302.

Celso BG, Ser SE, Snigurska UA, Solberg LM, Duckworth LJ, Dunn EM, Prosperi M, Lucero RJ, Bjarnadottir RI. Reconstruction of a Risk Analysis Tool That Uses Nursing Data for Frailty Assessment Among Older Adults: Derivation and Internal Evaluation Study. JMIR Aging. 2025 Dec 2;8:e67888. doi: 10.2196/67888. PubMed PMID: 41358446; PubMed Central PMCID: PMC12683501.

Marra F, Gomes K, Liu E, Vadlamudi NK, Richardson K, Cragg JJ. Effects of herpes zoster infection, antivirals and vaccination on risk of developing dementia: A systematic review and meta-analysis. Hum Vaccin Immunother. 2025 Dec;21(1):2546741. doi: 10.1080/21645515.2025.2546741. Epub 2025 Aug 19. PubMed PMID: 40828095; PubMed Central PMCID: PMC12557717.

Perkins CM, Jiang J, Shirlekar K, Greenberg Z, Siddique MAT, Brant J, Graim K, He M, Kim S, Wilkie DJ, Han B, Ali J, Belleau P, Deschenes A, Krasnitz A, Kanak M, Schmittgen TD. Transcriptomic analyses of normal human pancreata reveal the presence of cancer subtypes that correlate with acinar ductal metaplasia and donor ancestry. Cancer Res Commun. 2025 Dec 10. doi: 10.1158/2767-9764.CRC-25-0411. Online ahead of print. PubMed PMID: 41370448.

Hong JJ, Wilson DL, Nguyen K, Gellad WF, Diiulio J, Militello L, Yan S, Harle CA, Nelson D, Rosenberg EI, Schmidt S, Chang CH, Cochran G, Wu Y, Staras SAS, Kuza C, Lo-Ciganic WH. Protocol for a Single-Arm Pilot Clinical Trial: Developing and Evaluating a Machine Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE). J Clin Med. 2025 Dec 1;14(23):8522. doi: 10.3390/jcm14238522. PubMed PMID: 41375825; PubMed Central PMCID: PMC12693449.

Barajas J, Yang Z, Agyare E, Zhu X, Yoon SJ, Han B. Matrix stiffness influences drug resistance to gemcitabine analog and AZD 1775 combination in PDAC organoids. PLoS One. 2025 Dec 4;20(12):e0326550. doi: 10.1371/journal.pone.0326550. eCollection 2025. PubMed PMID: 41343527; PubMed Central PMCID: PMC12677491.

Kim D, Thiamwong L, Li Y, Suarez JRM, Xie R, Wang Y, Loerzel V. Modified Fall Risk Appraisal Matrix and Mental Health in Community-Dwelling Older Adults. Clin Gerontol. 2025 Dec 29:1-9. doi: 10.1080/07317115.2025.2606696. Online ahead of print. PubMed PMID: 41457967.

Costantino A, Festa B, Marchi F, Tsao CK, Pellini R, Gazzini L, Dziegielewski PT, Ciniglio M, Mazzola F, Calabrese L, Sarno A, Parrinello G, Chow L, Chen JK, Peretti G, De Virgilio A. Nomogram for Predicting Osteoradionecrosis After Fibula Free Flap for Mandibular Reconstruction. Head Neck. 2025 Dec 15. doi: 10.1002/hed.70138. Online ahead of print. PubMed PMID: 41392779.

Sahoo AK, Geldimuradov H, Smith KE, Zygala A, Cui Y, Lotfollahi M, Gong K, Zare A, Weisberg SM. Deep learning approaches to map individual differences in macroscopic neural structure with variations in spatial navigation behavior. Neuropsychologia. 2025 Dec 22;222:109352. doi: 10.1016/j.neuropsychologia.2025.109352. Online ahead of print. PubMed PMID: 41443585.

Wu J, Booker SQ, Marsiske M, Terry EL, Horgas AL. Do Depression and Anxiety Mediate the Relationship between Multi-dimensional Chronic Pain and Subjective Cognitive Decline? J Appl Gerontol. 2025 Dec 23:7334648251410984. doi: 10.1177/07334648251410984. Online ahead of print. PubMed PMID: 41431996.

Paudel B, Fieber J, Ahmed A, Shao C, Shah R, Agarwal A, Giansiracusa M, Qumseya B, Zori AG, Forsmark C, Novikov AA. Earlier Index Endoscopic Retrograde Cholangiopancreatography is Associated With Biliary Stricture Resolution After Orthotopic Liver Transplant. J Surg Res. 2025 Dec 17;317:446-452. doi: 10.1016/j.jss.2025.11.056. Online ahead of print. PubMed PMID: 41411772.

Rodhouse C, Barrios EL, Zeumer-Spataro L, Balzano-Nogueira L, Wu R, Yu X, Tian G, Brant JO, Gauthier ML, Chen J, Hernandez-Rios M, Polcz VE, Wiggins W, Charles AM, Dirain ML, Ungaro R, Rincon J, Loftus T, Xiao F, Cai G, Moldawer LL, Maile R, Kladde MP, Efron PA, Mathews CE. Prolonged Loss of Oxidative Phosphorylation and Mitochondrial Mass Characterize CD66b+ Leukocytes from Patients with Sepsis. bioRxiv [Preprint]. 2025 Dec 18:2025.12.16.694726. doi: 10.64898/2025.12.16.694726. PubMed PMID: 41446068; PubMed Central PMCID: PMC12723989.

Cancer Targeting and Therapeutics

Erwin N, De U, Xiao Y, Wang L, Maharjan CK, Pan X, Zuo D, Awasthee N, Zheng G, Liao D, Zhang W, He M. Proteolysis Targeting Chimera Loaded Extracellular Vesicles for Developing Triple Negative Breast Cancer Treatment. J Extracell Vesicles. 2025 Dec;14(12):e70211. doi: 10.1002/jev2.70211. PubMed PMID: 41416955; PubMed Central PMCID: PMC12716143.

Gbadamosi MO, Molchan E, Makarem MS, Coleman KL, Ohaegbulam AC, Streeks KH. Chemoimmunomodulation in triple negative breast cancer: a key to maximizing anti-PD-1 chemoimmunotherapeutic efficacy. Oncoimmunology. 2025 Dec;14(1):2527303. doi: 10.1080/2162402X.2025.2527303. Epub 2025 Jul 9. PubMed PMID: 40631451; PubMed Central PMCID: PMC12243914.

Zhou Y, Lu Q. Decoding higher-order tumor-microenvironment interactions via an innovative computational framework: Comment on “High-order interaction modeling of tumor-microenvironment crosstalk for tumor growth” by Che et al. Phys Life Rev. 2025 Dec 5;56:118-120. doi: 10.1016/j.plrev.2025.12.001. Online ahead of print. No abstract available. PubMed PMID: 41411905.

Rabinowitz Z, Anvar S, Liu J, Chen Z, Zhang Y, Cui C, Sigler A, Cui L. Tuning the efficiency of molecular probes via quinone methide-based in situ labeling. RSC Chem Biol. 2025 Dec 17. doi: 10.1039/d5cb00138b. Online ahead of print. PubMed PMID: 41416128; PubMed Central PMCID: PMC12709199.

Dixit D, Warren C, Duarte S, Neal D, Cabrera R, Zori AG, Zarrinpar A. Racial and Ethnic Disparities in Outcomes in Liver Transplantation for Hepatocellular Carcinoma. J Surg Res. 2025 Dec 6;317:116-131. doi: 10.1016/j.jss.2025.11.016. Online ahead of print. PubMed PMID: 41354024.

Middleton ML, Purvis C, Sun C, Busam KJ, Doonan B, Motaparthi K. Primary Cutaneous NUT Adnexal Carcinoma: A Case Report With Novel Clinical and Pathological Observations. J Cutan Pathol. 2025 Dec 14. doi: 10.1111/cup.70039. Online ahead of print. PubMed PMID: 41392342.

Kim C, Zhu Z, Tagmount A, Barbazuk WB, Bacher R, Vulpe CD. Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening. bioRxiv [Preprint]. 2025 Dec 19:2025.12.16.694776. doi: 10.64898/2025.12.16.694776. PubMed PMID: 41446145; PubMed Central PMCID: PMC12724170.

Davey EL, Gabaldon C, Reynolds PS, Ham K, Maxwell EA, Townsend KL, Bertran J. Diaphragmotomy enhances caudal liver displacement and hilus visualization in canine cadavers. Am J Vet Res. 2025 Dec 22:1-6. doi: 10.2460/ajvr.25.08.0297. Online ahead of print. PubMed PMID: 41429108.

Kim C, Tagmount A, Zhu Z, Wilson F, Li D, Ostrov DA, Barbazuk WB, Bacher R, Vulpe CD. Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells. bioRxiv [Preprint]. 2025 Dec 19:2025.12.16.694451. doi: 10.64898/2025.12.16.694451. PubMed PMID: 41446233; PubMed Central PMCID: PMC12724516.

Kundu S, Bennett Z, Guo J, Gupta P, Guo Z. Investigation of Intercellular Trafficking of Global Glycosylphosphatidylinositol-Anchored Proteins Using Cell Metabolic Engineering and Transwell Coculture. Angew Chem Int Ed Engl. 2025 Dec 16:e22420. doi: 10.1002/anie.202522420. Online ahead of print. PubMed PMID: 41400405.

Frank SJ, Busse PM, Lee JJ, Rosenthal DI, Hernandez M, Swanson DM, Garden AS, Gunn GB, Patel SH, Snider JW, Ma DJ, Molitoris JK, Lee NY, Parvathaneni U, McDonald MW, Kalman NS, Lin A, Mohammed N, Henson C, Hyde C, Bajaj GK, Katz SR, Dagan R, Morrison WH, Reddy JP, Fuller CD, Shah SJ, Phan J, Chronowski GM, Mayo L, Sturgis EM, Ferrarotto R, Zhu XR, Zhang X, Wang L, Hutcheson KA, El-Naggar AK, Moreno AC, Lee A, Spiotto MT, Gross ND, Lai SY, Liao JJ, Paly J, Liao Z, Foote RL; University of Texas MD Anderson Cancer Center Clinical Trial Consortium. Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial. Lancet. 2025 Dec 11:S0140-6736(25)01962-2. doi: 10.1016/S0140-6736(25)01962-2. Online ahead of print. PubMed PMID: 41391462.

Necchi A, Guerrero-Ramos F, Crispen PL, Herrera-Imbroda B, Garje R, Szabados B, Peyton CC, Pradere B, Ku JH, Shore N, Bogemann M, Preston MA, Xylinas E, Sanchez de Llano C, Gong C, Hasan M, Urtishak K, Battaglia S, Stitou H, Bhanvadia S, Sweiti H, Psutka SP. Gemcitabine intravesical system plus cetrelimab or cetrelimab alone as neoadjuvant therapy in patients with MIBC: primary analysis and biomarker results of SunRISe-4. J Clin Oncol. 2025 Dec 3:101200JCO2502382. doi: 10.1200/JCO-25-02382. Online ahead of print. PubMed PMID: 41337691.

George MRP, Elsadek LA, Deering M, de Almeida LC, Tyler JL, Noble A, Paul VJ, Luesch H, Butts CP, Aggarwal VK. Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues. Angew Chem Int Ed Engl. 2025 Dec 10:e23117. doi: 10.1002/anie.202523117. Online ahead of print. PubMed PMID: 41376297.

Samowitz P, Radnai L, Vaissiere T, Michaelson SD, Rojas C, Mitchell R, Kilinc M, Edwards A, Shumate J, Hawkins R, Fernandez-Vega V, Spicer TP, Scampavia L, Kamenecka T, Miller CA, Rumbaugh G. The Endo-GeneScreen platform identifies drug-like probes that regulate endogenous protein levels within physiological contexts. Nat Commun. 2025 Dec 9;16(1):10970. doi: 10.1038/s41467-025-65971-x. PubMed PMID: 41366089; PubMed Central PMCID: PMC12689758.

Huang M, Chen Y, Liang C, Narayan OP, Stallings C, Yu M, Traugot C, Li L, Li K, Vo Q, Wang H, Chou YT, Cech L, Parra D, Garzon L, Parsons D, Diaz E, Zhang C, Mackey C, Sussman H, Zmirska I, Chung M, Zhou C, Glynatsis G, Siemann DW, Licht JD, Li C, Kaye FJ, Xie M, Tan Y, Wu L, Bivona TG, Guan J, Tang X. Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability. Biomaterials. 2025 Dec 15;329:123920. doi: 10.1016/j.biomaterials.2025.123920. Online ahead of print. PubMed PMID: 41443038.

Phophi L, Wilt HM, Hu Z, Gadikota R, Cadiz M, Manzi MS, Ortiz Martinez FD, Vanga S, Chapman EG, Tibbetts SA, Karst SM. Maternal diet shapes milk bile acids to regulate neonatal growth through TGR5. Cell Rep. 2025 Dec 24;45(1):116744. doi: 10.1016/j.celrep.2025.116744. Online ahead of print. PubMed PMID: 41447527.

Castaneda-Leautaud AC, Srivastava A, Kim E, Chung D, Bannister TD, Amaro RE. Discovery of Tetrahydroisoquinoline-Based SARS-CoV-2 Helicase Inhibitors with Iterative, Deep Learning-Enhanced Virtual Screening. J Chem Inf Model. 2025 Dec 16. doi: 10.1021/acs.jcim.5c02059. Online ahead of print. PubMed PMID: 41400222.

Song R, Mikaeel RR, He Z, Horsnell M, Uylaki W, Meng W, Poplawski NK, Wollnik B, Li Y, Feng J, Scott HS, Shen Y, Wang C, Yin R, Ding Y, Llor X, Chung WK, Smith E, Price TJ, Young JP, Fan X. Identification of Novel Susceptibility Genes for Early-Onset Colorectal Cancer Through Germline Rare Variant Burden Testing. Cancers (Basel). 2025 Dec 9;17(24):3931. doi: 10.3390/cancers17243931. PubMed PMID: 41463182; PubMed Central PMCID: PMC12731108.

Vardon A, Haston S, Hamdi H, Cooksley G, Guiho R, Carvalho D, Carter R, Boult JKR, Gharai D, Cloete I, Grey J, Apps J, Zhou D, Zheng G, Martinez-Manez R, Lythgoe MF, Donovan LK, Carcaboso AM, Williams O, Hong Y, Alexandre P, Gil J, Dean JA, Michod D, Jones C, Hargrave D, Martinez-Barbera JP. Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma. Sci Rep. 2025 Dec 22;15(1):45094. doi: 10.1038/s41598-025-32676-6. PubMed PMID: 41430412; PubMed Central PMCID: PMC12749289.

Balduzzi A, Valsecchi MG, Tran TH, Zuna J, Leoni V, Cario G, Fazio G, Gandemer V, Tasian SK, van der Sluis IM, Peccatori N, Parasole R, Monterisi S, Loh ML, Devidas M, Hunger SP, Kairalla JA), De Lorenzo P, Silverman LB, Biondi A. Philadelphia chromosome-positive acute lymphoblastic leukaemia in children and adolescents: A changing treatment landscape and a methodological challenge. Br J Haematol. 2025 Dec 25. doi: 10.1111/bjh.70288. Online ahead of print. No abstract available. PubMed PMID: 41448829.

Chopra A, He HZ, Milosevic J, Tirukkovalur N, El Asmar R, Nassour I, Nunns G, Chen M, Chen J, Jiang S, Singhi AD, Saeed A, Zhang J, Lee K, Zureikat A, Zheng SY, Paniccia A. ASO Visual Abstract: KRAS Mutation Allele Frequency Dynamics in Plasma Extracellular Vesicles: Associations with Survival in Localized Pancreatic Adenocarcinoma. Ann Surg Oncol. 2025 Dec 12. doi: 10.1245/s10434-025-18842-0. Online ahead of print. No abstract available. PubMed PMID: 41385069.

London WB, Villanueva G, Shyr D, van Heerden J, Fuentes-Alabi S, Saab R, Harrison D, Papyan R, Kim Nguyen HT, Noun D, Kambugu J, Rascon J, Garami M, Guo D, Kao P, Naranjo A, Park JR, Cohn SL, Rodriguez-Galindo C, Matthay KK. Adaptive Clinical Neuroblastoma Risk Groups-Tailoring Treatment in Low- and Middle-Income Countries: An International Neuroblastoma Risk Group Project. JCO Glob Oncol. 2025 Dec;11:e2500349. doi: 10.1200/GO-25-00349. Epub 2025 Dec 23. PubMed PMID: 41435213.

Tuteja S, Hicks JK, Cavallari LH, El Rouby N, Smith DM, Patel JN, Hertz DL. Leveraging implementation science to enhance the adoption of DPYD testing. Pharmacogenet Genomics. 2025 Dec 16. doi: 10.1097/FPC.0000000000000581. Online ahead of print. No abstract available. PubMed PMID: 41396266.

Rodhouse C, Barrios EL, Zeumer-Spataro L, Balzano-Nogueira L, Wu R, Yu X, Tian G, Brant JO, Gauthier ML, Chen J, Hernandez-Rios M, Polcz VE, Wiggins W, Charles AM, Dirain ML, Ungaro R, Rincon J, Loftus T, Xiao F, Cai G, Moldawer LL, Maile R, Kladde MP, Efron PA, Mathews CE. Prolonged Loss of Oxidative Phosphorylation and Mitochondrial Mass Characterize CD66b+ Leukocytes from Patients with Sepsis. bioRxiv [Preprint]. 2025 Dec 18:2025.12.16.694726. doi: 10.64898/2025.12.16.694726. PubMed PMID: 41446068; PubMed Central PMCID: PMC12723989.

Immuno-Oncology and Microbiome

Newsome RC, Liu H, Agbodzi B, Gharaibeh RZ, Zhou L, Jobin C. Microbial-derived immunostimulatory small molecule augments anti-PD-1 therapy in lung cancer. Cell Rep Med. 2025 Dec 19:102519. doi: 10.1016/j.xcrm.2025.102519. Online ahead of print. PubMed PMID: 41421351.

Mendez-Gomez HR, Ligon JA, Ghiaseddin AP, Sayour EJ. Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity. Hum Vaccin Immunother. 2025 Dec;21(1):2543599. doi: 10.1080/21645515.2025.2543599. Epub 2025 Aug 19. PubMed PMID: 40827907; PubMed Central PMCID: PMC12366804.

Love CA, Figg JW, Engelbart M, West I, Flores C. Radial glial cells and glioblastoma: how developmental neurobiology can inform our understanding of brain cancer initiation, treatment resistance, and resilience. Transl Oncol. 2025 Dec 13;64:102645. doi: 10.1016/j.tranon.2025.102645. Online ahead of print. PubMed PMID: 41391380.

Saldanha EF, Noronha MM, Reis PCA, Passos PRC, Filho VOC, Cappellaro AP, Almeida LFC, Maselli-Shoueri JH, Lopes CDH, Leite LF, Ribeiro MF, Araujo DV. Tebentafusp in Metastatic Uveal Melanoma: A Meta-analysis. Target Oncol. 2025 Dec 3. doi: 10.1007/s11523-025-01187-9. Online ahead of print. PubMed PMID: 41335285.

Thorsen L, Law K, Walz J, Coll VM, Naramor A, Maitz C, Kubicek L, Thorsen Z, Gutti JR, Takada M. Outcome and Toxicity Profile of Stereotactic Body Radiation Therapy for Adrenal Tumours in Dogs. Vet Comp Oncol. 2025 Dec 17. doi: 10.1111/vco.70035. Online ahead of print. PubMed PMID: 41410158.

Canas JJ, Enslow SM, Bhimani S, Ferraro MJ. Extracellular vesicles decoying across host immunity. J Leukoc Biol. 2025 Dec 26;118(1):qiaf173. doi: 10.1093/jleuko/qiaf173. PubMed PMID: 41332248.

Chitre S, Gharaibeh RZ, Jobin C. A defined bacterial consortium and spatial transcriptomics highlight the complex interaction between Campylobacter jejuni and the murine intestine. Gut Microbes. 2025 Dec;17(1):2600053. doi: 10.1080/19490976.2025.2600053. Epub 2025 Dec 18. PubMed PMID: 41411657.

Bandela M, Geng X, Garcia JGN, Lee JC, Dudek SM. Nanomechanical Characterization of E-Cigarette-Induced Lung Endothelial Dysfunction: Roles of Cortactin and Mitochondrial Reactive Oxygen Species. Int J Mol Sci. 2025 Dec 16;26(24):12104. doi: 10.3390/ijms262412104. PubMed PMID: 41465530; PubMed Central PMCID: PMC12733622.

Coker MO, Kreutzberg R, Sam-Agudu NA, Macodiyo E, Jumare J, Madan J, Singhal V, Li Z, Robbins R, Shiau S. The State of the Science on Chronic Comorbidities and Aging in Children and Adolescents with perinatally-acquired HIV. Curr HIV/AIDS Rep. 2025 Dec 6;22(1):56. doi: 10.1007/s11904-025-00761-0. PubMed PMID: 41351790; PubMed Central PMCID: PMC12681470.

Mechanisms of Oncogenesis

Wang Q, Pan Y, Zhou M, Tang Z, Wang Y, Wang G, Song Q. scDrugMap: benchmarking large foundation models for drug response prediction. Nat Commun. 2025 Dec 11. doi: 10.1038/s41467-025-67481-2. Online ahead of print. PubMed PMID: 41381537.

McMahon S, Amer M, Hall B, Shekhar R, Renne R. Targeted Protein Degradation of the Latency-Associated Nuclear Antigen Evicts Kaposi Sarcoma-Associated Herpesvirus Episomes From Infected Cells In Vitro. J Med Virol. 2025 Dec;97(12):e70765. doi: 10.1002/jmv.70765. PubMed PMID: 41431365; PubMed Central PMCID: PMC12723335.

Kim MC, Gu T, Seo H, Moon Y, Borcherding N, Kolb R, Kim Y, Yun Y, Song WJ, Lee CY, Kim HJ, Zhang W. High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs. Front Immunol. 2025 Dec 18;16:1680437. doi: 10.3389/fimmu.2025.1680437. eCollection 2025. PubMed PMID: 41488614; PubMed Central PMCID: PMC12756145.

Fu R, Yu W, Zhao R, Yang H, Cao B, Dai C, Qianjiang H, Xia Y, Wang L, Lu J, Zhou R, Shi A, Lou H, Zhang X, Luo H. The METTL3-YTHDC1 axis mediates architectural RNA m6A modification to modulate the integrity of chromatin TADs in MLLr + AML genome. Mol Cancer. 2025 Dec 22. doi: 10.1186/s12943-025-02545-x. Online ahead of print. No abstract available. PubMed PMID: 41430607.

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Gao H, Ren D, Giannico GA, Akgul M, Khani F, Galea LA, Al-Obaidy KI, Falzarano SM, Wobker SE, Barry-Holson KQ, Chan E, McHenry AJ, Sangoi AR. Do urinary bladder smooth muscle neoplasms show morphologic and immunophenotypic features of their uterine fumarate hydratase-deficient counterparts? Ann Diagn Pathol. 2025 Dec;79:152536. doi: 10.1016/j.anndiagpath.2025.152536. Epub 2025 Aug 5. PubMed PMID: 40811990.

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Kim C, Tagmount A, Zhu Z, Wilson F, Li D, Ostrov DA, Barbazuk WB, Bacher R, Vulpe CD. Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells. bioRxiv [Preprint]. 2025 Dec 19:2025.12.16.694451. doi: 10.64898/2025.12.16.694451. PubMed PMID: 41446233; PubMed Central PMCID: PMC12724516.