February Publications » Cancer Institute » UF Health Cancer Institute

Recent publications from the UF Health Cancer Institute.

Cancer Control and Population Sciences

Shabnaz S, Farber-Eger E, Tantawy M, Shahisavandi N, Garrett TJ, Rubinstein SM, Fradley MG, Alomar ME, DeAvila D, Shain KH, Cornell RF, Lenihan D, Lu Q, Wells QS, Baz RC, Gong Y. Causal Effects of Hydrophilic Bile Acids on Carfilzomib-Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study. Clin Pharmacol Ther. 2026 Feb 1. doi: 10.1002/cpt.70222. Online ahead of print. PubMed PMID: 41622719.

Karanth SD, Valvi N, Shinde MM, Kowalik F, Aroh A, Mehta HJ, Gould MK, Braithwaite D. Socioeconomic Factors Associated with Receipt of Minimally Invasive Surgery for NSCLC: Evidence from the National Cancer Database. Cancers (Basel). 2026 Feb 12;18(4):601. doi: 10.3390/cancers18040601. PubMed PMID: 41749854; PubMed Central PMCID: PMC12939167.

Huang Y, Li Y, Lou X, Islam JY, Liang M, George TJ, Bian J, Guo Y. Breast cancer screening and cancer prognosis in patients with Alzheimer’s disease and related dementias. JNCI Cancer Spectr. 2026 Feb 27:pkag019. doi: 10.1093/jncics/pkag019. Online ahead of print. PubMed PMID: 41761572.

Yasinzai AK, Smith J, Lertkitcharoenpo A, Bourricaudy RA, Chang JJ, Stringer TF, DiBianco JM, Joseph JP, O’Malley P, Crispen PL, Su LM, Benidir T. Patient awareness and perspectives regarding the value of focal therapy for localized prostate cancer: A cross-sectional study. Urol Oncol. 2026 Feb 6;44(4):110993. doi: 10.1016/j.urolonc.2026.110993. Online ahead of print. PubMed PMID: 41655341.

Crowe A, Vasquez TT, Wright KB, Fisher CL, Johnson SB, Paige SR, Sae-Hau M, Weiss ES, Bylund CL. Blood cancer caregivers’ communication with clinicians about online cancer information. Palliat Support Care. 2026 Feb 12;24:e56. doi: 10.1017/S1478951526101692. PubMed PMID: 41673958.

Reed T, Gordon D, Dyal BW, Powell-Roach K, Ezenwa MO, Johnson-Mallard V, Krieger JL, Odedina FT, Yao Y, Wilkie DJ. Demographic factors and rural residence history associated with smoking history. J Am Assoc Nurse Pract. 2026 Feb 24. doi: 10.1097/JXX.0000000000001257. Online ahead of print. PubMed PMID: 41733483.

Nesbit TS, Bryan E, Wollney EN, Armstrong MJ, Bylund CL, Fisher CL. Supporting Family Caregivers’ Clinical Communication Skills: Adapting a Cancer Caregiver Communication Model for Dementia Caregiving. Int J Environ Res Public Health. 2026 Feb 10;23(2):225. doi: 10.3390/ijerph23020225. PubMed PMID: 41752308; PubMed Central PMCID: PMC12941134.

Alshammari RA, Rubinstein SM, Farber-Eger E, Shaffer LL, Tantawy M, Alomar ME, Wells QS, Lenihan D, Cornell RF, Shain KH, Baz RC, Gong Y. Epigenome-Wide Association Studies of Proteasome Inhibitor-Related Cardiotoxicity in Patients with Multiple Myeloma. Cancers (Basel). 2026 Feb 3;18(3):505. doi: 10.3390/cancers18030505. PubMed PMID: 41681977; PubMed Central PMCID: PMC12896721.

Dinwiddie LE, Baggett JM, Kofler JM, Kofler CB, Long DJ, Dawson RJ, Wehmeier SK, Wang Y, Ocampo-Ramos JC, Carter LM, Marquis H, Kayal G, Kesner AL, Bolch WE. Survey of normalized CTDIvol values across four major computed tomography vendors for use in the MIRDct software. J Appl Clin Med Phys. 2026 Feb;27(2):e70473. doi: 10.1002/acm2.70473. PubMed PMID: 41588631; PubMed Central PMCID: PMC12835190.

Mazirka P, Cremer J, Balch J, Nordenstam J, Read TE, Grajo JR, Peters J, Terracina KP. Immersive Virtual Realty 3D Model for Rectal Cancer Surgical Planning. Dis Colon Rectum. 2026 Feb 24. doi: 10.1097/DCR.0000000000004140. Online ahead of print. No abstract available. PubMed PMID: 41733146.

Benites C, Davila CE, Conrad DJ, Lam A, Reschly W, Nessif R, Motwani K, Dziegielewski PT. Jaw-in-a Day: Process Improvement and Outcomes. Otolaryngol Head Neck Surg. 2026 Feb 19. doi: 10.1002/ohn.70179. Online ahead of print. PubMed PMID: 41711575.

Benites C, White C, Balaguru L, Gonghao L, Lee JH, Conrad DJ, Lam A, Dziegielewski PT. Does discharge location following head and neck cancer surgery affect quality outcomes? Oral Oncol. 2026 Feb 11;175:107879. doi: 10.1016/j.oraloncology.2026.107879. Online ahead of print. PubMed PMID: 41679078.

Baggett J, Dawson RJ, Dinwiddie L, Smither WW, Wang Y, Wehmeier S, Tran T, Pathak S, Domal SJ, Kofler C, Choi C, Yeom YS, Carter L, Ocampo Ramos JC, Zanzonico P, Kesner A, Bolch WE. The UF/MSK pediatric mesh-based computational human phantom library: applications to organ dosimetry in computed tomography. Phys Med Biol. 2026 Feb 25. doi: 10.1088/1361-6560/ae4a81. Online ahead of print. PubMed PMID: 41740258.

Hochhegger B, Zanetti G, Marchiori E. Tuberculosis suggesting lung cancer. Rev Soc Bras Med Trop. 2026 Feb 6;59:e04032025. doi: 10.1590/0037-8682-0403-2025. eCollection 2026. No abstract available. PubMed PMID: 41670083; PubMed Central PMCID: PMC12880760.

Johnson PB, Robbert B, Fleming T, Dillinger T, Kirby K, Heath K, Mendenhall NP. Management of a Multi-Room Downtime Event in a Multi-System Environment: A Case Report in Proton Therapy Operations. Int J Part Ther. 2026 Feb 7;19:101306. doi: 10.1016/j.ijpt.2026.101306. eCollection 2026 Mar. PubMed PMID: 41732481; PubMed Central PMCID: PMC12925582.

Reiners K, Viviers E, Getman N, Kirby K, Johnson PB, Mendenhall NP, Zhang Y, Mailhot Vega RB. Comparing Organs at Risk Sparing Between Intensity-Modulated Radiotherapy and Pencil-Beam Scanning Plans Based on Disease Location for Hodgkin and Non-Hodgkin Lymphoma. Int J Part Ther. 2026 Feb 11;19:101307. doi: 10.1016/j.ijpt.2026.101307. eCollection 2026 Mar. PubMed PMID: 41756748; PubMed Central PMCID: PMC12933442.

Imran M, Brisbane WG, Su LM, Joseph JP, Shao W. AI-enhanced micro-ultrasound improves detection of clinically significant prostate cancer at biopsy. BJUI Compass. 2026 Feb 5;7(2):e70133. doi: 10.1002/bco2.70133. eCollection 2026 Feb. PubMed PMID: 41658334; PubMed Central PMCID: PMC12877317.

Smuder AJ, Doerr V, Jacintho Moritz CE, Li J, Nguyen BL. Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation. J Cachexia Sarcopenia Muscle. 2026 Feb;17(1):e70171. doi: 10.1002/jcsm.70171. PubMed PMID: 41545030; PubMed Central PMCID: PMC12811061.

Lyu M, Li X, Chen Z, Pan J, Peng C, Talankar S, Wu Y. Natural language generation in healthcare: A review of methods and applications. J Biomed Inform. 2026 Feb 10;176:104997. doi: 10.1016/j.jbi.2026.104997. Online ahead of print. PubMed PMID: 41679677.

da Fonseca JM, Carvalho AR, Rodrigues RS, Conrado M, Basilio R, Machuca T, Hochhegger B. Comparison of a Natural Language Processing Model and Large Language Models for Extracting Incidental Lung Nodule Data. Radiol Cardiothorac Imaging. 2026 Feb;8(1):e250210. doi: 10.1148/ryct.250210. No abstract available. PubMed PMID: 41642063.

Ocampo Ramos JC, Kofler C, Dawson R, Baggett J, Dinwiddie LE, Domal SJ, Carter LM, Marquis H, Kayal G, Zanzonico PB, Bolch WE, Kesner AL. MIRD Pamphlet No. 34, Part 1: MIRDct-A Customizable Software Tool for CT Dosimetry. J Nucl Med. 2026 Feb 12:jnumed.125.270494. doi: 10.2967/jnumed.125.270494. Online ahead of print. PubMed PMID: 41679920.

Nugent SM, Ashare RL, Cullen J, Haque R, Hu J, Lee RT, Meghani SH, Potosky AL, Reboussin BA, Romero-Sandoval A, Wagoner KG, Wang Y, Worster B, Filipski KK, Freedman AN. Leveraging the national cancer institute’s collaborative efforts to understand the benefits and harms of cannabis use among individuals with cancer. J Natl Cancer Inst. 2026 Feb 26:djag057. doi: 10.1093/jnci/djag057. Online ahead of print. PubMed PMID: 41746285.

Dullius CR, Rodrigues MT, Forte GC, Andrade Feijo RG, Athanazio RA, Hochhegger B, Pinto LA. Opportunistic thoracic CT scan over bone densitometry in CF care: Is it possible to screen for osteoporosis using a CT scan? Respir Med. 2026 Feb 27:108739. doi: 10.1016/j.rmed.2026.108739. Online ahead of print. PubMed PMID: 41765053.

Freyer DR, Haydon MD, Kelly RK, Mobley EM, Mack W, Roth ME, Miller KA, Hamilton AS, Milam JE. Symptom burden among long-term survivors of young adult cancer: a report from the Project Milestones cohort. J Cancer Surviv. 2026 Feb 20. doi: 10.1007/s11764-026-01986-7. Online ahead of print. PubMed PMID: 41714555.

Cohen LW, Dolor RJ, Weiner M, Zemon N, Bailey C, Carton T, Cottrell E, Forrest CB, Hernandez AF, Kaushal R, Marsolo K, McTigue K, Rothman RL, Shenkman E, Waitman LR; on behalf of the PCORnet Steering Committee. PCORnet(R): 10 Years of Research Innovation. Med Care. 2026 Feb 1;64(2S Suppl 3):S185-S190. doi: 10.1097/MLR.0000000000002269. Epub 2025 Dec 3. PubMed PMID: 41504745; PubMed Central PMCID: PMC12783338.

Nauman E, McTigue K, Shenkman EA, Djibo DA, Carton TW. Partnerships With Health Plans to Link Data From Electronic Health Records to Claims for Research Using PCORnet(R). Med Care. 2026 Feb 1;64(2S Suppl 3):S213-S218. doi: 10.1097/MLR.0000000000002244. Epub 2026 Jan 8. PubMed PMID: 41504749; PubMed Central PMCID: PMC12783351.

Ramos-Fresnedo A, Pather K, Yap CR, Celso BG, Mobley EM, Awad ZT. Robotic vs. laparoscopic Ivor Lewis esophagectomy for esophageal cancer: a weighted short- and long-term outcomes analysis. Surg Endosc. 2026 Feb 26. doi: 10.1007/s00464-026-12672-1. Online ahead of print. PubMed PMID: 41748955.

Palermo TM, Ohls O, Dear B, Doorenbos AZ, Yadav D, Zhou C, Bellin M, Fisher W, Fogel E, Forsmark C, Hart PA, Park WG, Pandol S, Trikudanathan G, Conwell DL. Digital cognitive-behavioral therapy for pain management in individuals with recurrent acute and chronic pancreatitis (IMPACT-2): study protocol for a hybrid effectiveness-implementation trial. Trials. 2026 Feb 9. doi: 10.1186/s13063-026-09517-6. Online ahead of print. PubMed PMID: 41664170.

Cancer Targeting and Therapeutics

Chen CY, Chou WC, Kamineni VN, Wu PY, Zhang Z, Wu X, Vulpe CD, Lin Z. Toxicophore-informed machine learning integrating Tox21 assay readouts for organ system-specific carcinogenicity prediction. Environ Pollut. 2026 Feb 1;390:127519. doi: 10.1016/j.envpol.2025.127519. Epub 2025 Dec 11. PubMed PMID: 41389866.

Wen Y, Shi J, Deng Y, Shepard Q, Gao X, Zeng Y. Extracellular Vesicle Analysis: Recent Technological Advances and Emerging Opportunities. Annu Rev Anal Chem (Palo Alto Calif). 2026 Feb 17. doi: 10.1146/annurev-anchem-070325-084902. Online ahead of print. PubMed PMID: 41701905.

Kiefer AF, Steele AD, Rader C, Shen B. DVD-IgG1 antibody-drug conjugates: Expanding the landscape of targeted cancer therapy. Curr Opin Chem Biol. 2026 Feb 23;92:102653. doi: 10.1016/j.cbpa.2026.102653. Online ahead of print. PubMed PMID: 41734646.

Shukla S, Pogash S, Venkatesh A, McGrath J, Rosales RDR, Kanumuambidi JP, Al-Toubat M, Fletcher S, Balaji KC. A novel aurora kinase molecular glue-based degrader sp-2-067 inhibits prostate cancer cell growth and alters immune profile. Invest New Drugs. 2026 Feb 21. doi: 10.1007/s10637-026-01603-5. Online ahead of print. PubMed PMID: 41721176.

Kodadek T. Proteins feel the PINCH. Nat Chem Biol. 2026 Feb 5. doi: 10.1038/s41589-025-02133-6. Online ahead of print. No abstract available. PubMed PMID: 41644847.

Chen H, Zhu D, Billitti M, Sun A, Jin L, Moser E, Mivechi NF, Zheng G, Lv D. Development of PolyHis-Targeting PROTAC Degraders. Angew Chem Int Ed Engl. 2026 Feb 2:e22845. doi: 10.1002/anie.202522845. Online ahead of print. PubMed PMID: 41630184.

Malave JG, Thomas CD, Franchi F, Keeley EC, McDonough CW, Ortega-Paz L, Shao D, Rossi JS, Stouffer GA, Rouhizadeh M, Angiolillo DJ, Lee CR, Cavallari LH. Impact of Area-Level Socioeconomic Deprivation on Post-PCI Outcomes Stratified by P2Y12 Inhibitor Therapy. JACC Adv. 2026 Feb 3;5(3):102577. doi: 10.1016/j.jacadv.2025.102577. Online ahead of print. PubMed PMID: 41638031; PubMed Central PMCID: PMC12892058.

Garg A, Blume SY, Huynh H, Barrios AM, Karabulut OO, Zhao Q, Midha AD, Turner AW, Resnick BV, Chen X, Agrawal A, Kim J, Chen L, Ran Q, Ryan AM, Larson RC, Negahban M, Nelson SCK, Yang AC, Traglia M, Thomas R, Sun R, Paredes M, Corces MR, Lin H, Jain IH. Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease. Cell. 2026 Feb 25:S0092-8674(26)00109-1. doi: 10.1016/j.cell.2026.01.022. Online ahead of print. PubMed PMID: 41747729.

Gadallah MI, Nonhof KL, Nayak D, Zhang P, Dioli O, Zheng G, Olsen SK, Zhou D, Brodbelt JS. Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry. Chem Sci. 2026 Feb 19. doi: 10.1039/d5sc07400b. Online ahead of print. PubMed PMID: 41727719; PubMed Central PMCID: PMC12917756.

Zhang S, Daniels ER, McGue J, Sudharshan R, Kim HC, Thomas DG, Krishnan S, Frankel TL, Hissong E, Rao A, Assarzadegan N, Shi J. Elevated T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Expression and Immune Cell Dysfunction Characterize Complex Proteins Associated With SET1 (COMPASS)-Like Complex Gene-Mutated Pancreatic Ductal Adenocarcinoma (PDAC). Mod Pathol. 2026 Feb 2;39(4):100972. doi: 10.1016/j.modpat.2026.100972. Online ahead of print. PubMed PMID: 41638576.

Davey A, Chen Davies LS, Pan S, Krommenhoek KB, Foster-Thomas E, Maagdenberg NH, Brennan B, Charlwood F, Gaito S, Gaze MN, Gillies C, Goyal L, Eccles CL, Indelicato DJ, Krasin M, Mandeville HC, Slater O, Whitfield G, Hol MLF, Aznar MC. Systematic review of facial deformation following paediatric head and neck radiation therapy: A call for standardised outcome assessment and dose-response evidence. Radiother Oncol. 2026 Feb 19:111448. doi: 10.1016/j.radonc.2026.111448. Online ahead of print. PubMed PMID: 41722821.

Mojica-Santiago JA, Agarwal G, Robles-Blasini S, Young IC, Lopez VA, Giza S, Choi A, Malany S, Schmidt CE. Comparative Analysis of Matrigel and Tunable Collagen-Fibrin Blends for in Vitro Skeletal Muscle Models. J Biomed Mater Res A. 2026 Feb;114(2):e70039. doi: 10.1002/jbma.70039. PubMed PMID: 41622869.

ElSayed ElZorkany H, Kandil H, Jayaraman S, Aly A, Esfahani SH, Patel D, Dannecker D, Maciag M, Paul A, Lowran K, Kumari S, Bose S, Ostrov DA, Wu CG, Dickson A, Abbruscato TJ, Trippier PC, Orlando BJ, Karamyan VT. Discovery of a pyridine-piperazine-based small molecule that enhances the activity of peptidase neurolysin. J Pharmacol Exp Ther. 2026 Feb 3;393(3):103827. doi: 10.1016/j.jpet.2026.103827. Online ahead of print. PubMed PMID: 41759240.

Krommenhoek KB, Foster-Thomas E, Davey A, Davies LSC, Maagdenberg NH, Charlwood F, Gaito S, Goyal L, Gillies C, Slater O, Brennan B, Gaze MN, Eccles CL, Becking AG, Merks JHM, Mandeville HC, Indelicato DJ, Krasin M, Pan S, Aznar MC, Hol MLF. Systematic Review of Late Dental Effects Following Head and Neck Radiation Therapy in Childhood Cancer Survivors. Pract Radiat Oncol. 2026 Feb 19:S1879-8500(25)00329-7. doi: 10.1016/j.prro.2025.12.011. Online ahead of print. PubMed PMID: 41711607.

Boyce RT, Harlan CJ, Wang Q, Walker CM, Lai SY, Merritt ME, Bankson JA. Physiological Interpretation of the Lactate to Pyruvate AUC Ratio for Hyperpolarized [1-13C]-Pyruvate Studies. Magn Reson Med. 2026 Feb 27. doi: 10.1002/mrm.70309. Online ahead of print. PubMed PMID: 41761412.

Embring A, Skytta T, Engellau J, Kerna I, Sendiuliene D, Blomstrand M, Indelicato DJ, Timmermann B, Lassen-Ramshad Y, Magelssen H. Nordic Society of Paediatric Haematology and Oncology (NOPHO) Radiotherapy Working Group consensus guidelines on radiotherapy for paediatric low-grade gliomas. Acta Oncol. 2026 Feb 15;65:101-108. doi: 10.2340/1651-226X.2026.44815. PubMed PMID: 41693214; PubMed Central PMCID: PMC12926702.

Herremans KM, Zeng W, Riner AN, McKean JA, Thompson G, Neal DW, Nassour I, Trevino JG, Benos PV, Hughes SJ. Neoadjuvant Radiation is Causally Linked to Increased Operative Time and Perioperative Blood Transfusion in Pancreatic Ductal Adenocarcinoma. J Surg Res. 2026 Feb 19;320:23-32. doi: 10.1016/j.jss.2026.01.031. Online ahead of print. PubMed PMID: 41719621.

Berger AC, Bertran J, Williams RW, Hawkins I. Aural Cholesteatoma (Tympanokeratoma) in Veterinary Medicine: An Update and Principles of Clinical Management. Vet Dermatol. 2026 Feb 17. doi: 10.1111/vde.70053. Online ahead of print. PubMed PMID: 41703947.

Chang MC, Merritt ME, Keshari KR. The state of imaging glycolytic metabolism in cancer with magnetic resonance. Npj Imaging. 2026 Feb 10;4(1):9. doi: 10.1038/s44303-026-00146-x. PubMed PMID: 41667628; PubMed Central PMCID: PMC12891726.

Immuno-Oncology and Microbiome

Elliott L, Loeb DM, Trucco M. Management of pediatric bone sarcomas. Curr Opin Pediatr. 2026 Feb 1;38(1):45-52. doi: 10.1097/MOP.0000000000001535. Epub 2025 Dec 5. PubMed PMID: 41363185.

Campian JL, Le SB, Ghiaseddin A, Butt OH, Manektalia H, Chen D, Xu Y, Liu J, Rahman M, Thai N, Leidig WA, Johanns T, Ansstas G, Zhou AY, Pugazenthi S, Dunn GP, Huang J, Chheda MG, Kim AH, Leuthardt EC, Tran DD. Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial. Nat Commun. 2026 Feb 26;17(1):1763. doi: 10.1038/s41467-026-69522-w. PubMed PMID: 41748622; PubMed Central PMCID: PMC12946167.

Mechanisms of Oncogenesis

Yuan Q, Guryanova OA. When Coconspirators Avert the Crime: Clonal Hematopoiesis Driven by TET2 Loss Improves Response to Cancer Immunotherapy. Cancer Res. 2026 Feb 16;86(4):825-826. doi: 10.1158/0008-5472.CAN-25-4497. PubMed PMID: 41693377.

Xu X, Liu X, Jarajapu V, Neelature Sriramareddy S, Konecny F, Posorske B, Dollar JJ, Liu X, Jasani N, Wang K, Mecozzi N, Soto-Vargas Z, Ochoa-Rios SL, Murikipudi H, Phan N, Chadourne M, Kuznetsoff JN, Sinard J, Bennett RL, Licht JD, Smalley KSM, Harbour JW, Yu X, Karreth FA. A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma. Cancer Res. 2026 Feb 9. doi: 10.1158/0008-5472.CAN-25-2684. Online ahead of print. PubMed PMID: 41661679.