March Publications » Cancer Institute » UF Health Cancer Institute

Recent publications from the UF Health Cancer Institute.

Cancer Control and Population Sciences

Henderson RH, Bryant CM, Nichols RC Jr, Mendenhall WM, Morris CG, Artz ME, Johnson PB, Balaji KC, Mendenhall NP. Ten-year outcomes for image-guided moderately hypofractionated proton therapy for prostate cancer. Radiother Oncol. 2026 Mar 8;219:111482. doi: 10.1016/j.radonc.2026.111482. Online ahead of print. PubMed PMID: 41806873.

Reid MJ, Montague MK, Anrecio S, LeLaurin JH, Bylund CL, Minion MM, Liu G, Lee JH, Ramly E, Shelley D, Ostroff JS, Warren G, Salloum RG. Sustainability through funding and leadership: a mixed-methods study of tobacco treatment programs across U.S. National Cancer Institute-designated Cancer Centers. Implement Sci Commun. 2026 Mar 16. doi: 10.1186/s43058-026-00900-7. Online ahead of print. PubMed PMID: 41840628.

Yang GS, Starkweather A, Lin T, Hashemian T, Garrett TJ, Fanfan D, Cousin L, Patel S, Kelly DL, Lyon DE. Serum metabolomic profiles associated with psychoneurological symptoms in women with early-stage breast cancer over one year. Front Oncol. 2026 Mar 12;16:1779012. doi: 10.3389/fonc.2026.1779012. eCollection 2026. PubMed PMID: 41907595; PubMed Central PMCID: PMC13019887.

Algarin Perneth S, Patel U, Ortiz Rocha A, Barb D, Acosta G, Srihari A, Dziegielewski P, Castro MR, Dean D, Ryder M, Hargraves I, Bylund C, Roy A, Zhang Z, Montori VM, Brito JP, Singh Ospina NM. Evaluation of a conversation aid for patients with thyroid nodules considering a biopsy: pilot multicenter randomized control trial. Endocrine. 2026 Mar 9;91(1):92. doi: 10.1007/s12020-025-04517-z. PubMed PMID: 41801576; PubMed Central PMCID: PMC12971928.

Washington CJ, Karanth SD, Silvestri GA, Datta S, Canidate S, Gould MK, Braithwaite D. Sociodemographic differences in clinical phenotypes among patients with COPD: a latent class analysis. BMJ Open Respir Res. 2026 Mar 2;13(1):e003767. doi: 10.1136/bmjresp-2025-003767. PubMed PMID: 41771670; PubMed Central PMCID: PMC12958988.

Peng C, Dong X, Lyu M, Paredes D, Zhang Y, Wu Y. A study of large language models for patient information extraction: Model architecture, fine-tuning strategy, and multi-task instruction tuning. J Biomed Inform. 2026 Mar 27:105034. doi: 10.1016/j.jbi.2026.105034. Online ahead of print. PubMed PMID: 41905520.

Choi C, Dawson RJ, Shin B, Wang Y, Tran-Gia J, Ramirez MS, Theisen AL, Lassmann M, Bolch WE. Mesh-based detailed skeletal models for the ICRP reference pediatric individuals: development and dosimetric implications. Phys Med Biol. 2026 Mar 19;71(6). doi: 10.1088/1361-6560/ae501a. PubMed PMID: 41806492.

Zhu Y, Suk R, Lin YY, Hong YR, Virnig B. Cardiovascular Mortality Risk After Cancer Diagnosis by County-Level Characteristics in the United States 2000-2021. Cancer Med. 2026 Mar;15(3):e71675. doi: 10.1002/cam4.71675. PubMed PMID: 41741192; PubMed Central PMCID: PMC12935517.

Dalisay F, Okamoto SK, Kawabata Y, Herzog TA, Pokhrel P. A pilot stratified cluster randomized trial of school-based e-cigarette and other tobacco product use prevention for Pacific Island youths: An evaluation of the Fuetsan Manhoben curriculum. Tob Induc Dis. 2026 Mar 24;24. doi: 10.18332/tid/218296. eCollection 2026. PubMed PMID: 41884082; PubMed Central PMCID: PMC13012013.

Forsmark CE, Pandol S. The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) 10 years of Past Accomplishments and Looking Forward to the Next 5 Years of the Chronic Pancreatitis Clinical Research Consortium (CPCRC). Pancreas. 2026 Mar 2. doi: 10.1097/MPA.0000000000002629. Online ahead of print. PubMed PMID: 41771024.

Forsmark CE. Are the drugs already on the shelf? Repurposing therapy for pancreatitis. Gut. 2026 Mar 3:gutjnl-2025-337879. doi: 10.1136/gutjnl-2025-337879. Online ahead of print. No abstract available. PubMed PMID: 41775515.

Hernandez-Rios M, Rincon J, Balzano-Nogueira L, Polcz V, Wang D, Wiggins W, Rodhouse C, Yoham A, Xiao F, Ungaro R, Dirain M, Moldawer L, Maile R, Cai G, Efron P, Larson S. Preterm birth skews the developmental trajectory of myeloid-derived suppressor cells in the first 48 hours of life: single-cell transcriptomics and inferred intercellular communication. Mol Med. 2026 Mar 27. doi: 10.1186/s10020-026-01459-8. Online ahead of print. No abstract available. PubMed PMID: 41888646.

Chen Y, Du F, Singh Ospina NM, Brito JP, Shao H, Liu Q, McCoy RG, Jiao T. Patterns of Thyroid-Stimulating Hormone Test After GLP-1 RAs Initiation in Patients on Levothyroxine: A Trial Emulation Study. J Clin Endocrinol Metab. 2026 Mar 27:dgag131. doi: 10.1210/clinem/dgag131. Online ahead of print. PubMed PMID: 41902399.

Du F, George TJ, Guo Y, Khosrow-Khavar F, Liu Q, Perkins CM, Jiang J, DeRemer DL, McDonough C, Lian Y, Schmittgen TD, Jiao T. Renin-angiotensin-aldosterone system inhibitors and risk of pancreatic cancer in older adults: A target trial emulation. Int J Cancer. 2026 Mar 23. doi: 10.1002/ijc.70438. Online ahead of print. PubMed PMID: 41872700.

McKean J, Underwood P, Yasinzai AQK, George T, Sahin I, Fabregas J, Qumseya B, Novikov A, Chua T, Paniccia A, Hitchcock KE, Hughes S, Nassour I. Neoadjuvant Therapy for Localized Pancreatic Cancer. Cancers (Basel). 2026 Mar 20;18(6):1011. doi: 10.3390/cancers18061011. PubMed PMID: 41899612; PubMed Central PMCID: PMC13024805.

Kweyete OMT, Whitner C, Deremer DL, Guo Y, Bian J, Scarton L, Rogers SC, Wilkie DJ, Lou X, Allen JM. Racial Disparities in Non-Stigmatized Supportive Care Medication Use in Pancreatic Cancer. J Pain Symptom Manage. 2026 Mar 3:S0885-3924(26)00086-2. doi: 10.1016/j.jpainsymman.2026.02.025. Online ahead of print. PubMed PMID: 41785943.

Marchiori E, Hochhegger B, Zanetti G. Lung cancer associated with cystic airspaces: an underrecognized condition. J Bras Pneumol. 2026 Mar 20;51(6):e20250385. doi: 10.36416/1806-3756/e20250385. No abstract available. PubMed PMID: 41880398.

Klein K, Tucker CM, Vemugunta V, Anton S, Lee JH, Li D, Belcher M, Miles-Hamilton J. Factors Associated with Emergency Department Utilization among Older Black Adults with Chronic Illness in the United States. J Racial Ethn Health Disparities. 2026 Mar 23. doi: 10.1007/s40615-026-02923-1. Online ahead of print. No abstract available. PubMed PMID: 41870850.

Winsnes K, Bradley JA, Gao Z, Gupta AA, Rothstein DH, Shenoy A, Venkatramani R, Xue W, Arndt C. Intermediate Risk Rhabdomyosarcoma in Very Young Children (Less Than or Equal to 24 months) Treated on the Prior Children’s Oncology Group Protocol ARST1431. Pediatr Blood Cancer. 2026 Mar 31:e70293. doi: 10.1002/1545-5017.70293. Online ahead of print. PubMed PMID: 41914453.

Rodgers-Melnick SN, Gorthi V, Foss A, Erande A, DiFrancesco K, Owusu-Ansah A, Anim S, Bretz S, Ketter P, Fuqua T, Anderson AR, Karasz A, Bailey L, Ezenwa M, Jenerette C, Dusek JA. MULTIsite feasibility of MUSIc therapy to address Quality Of Life in Sickle cell disease (MULTI-MUSIQOLS): protocol for a mixed-methods randomised controlled trial at two US medical centres. BMJ Open. 2026 Mar 9;16(3):e115036. doi: 10.1136/bmjopen-2025-115036. PubMed PMID: 41802789; PubMed Central PMCID: PMC12983906.

Bartelli TF, Baydogan S, Sahin I, Hoffman KL, Petrosino J, Blackburn KW, Zhao J, Wood A, Ayvaz T, Surathu A, Cagigas MN, Barcenas EC, Mata T, Nguyen VK, Zulbaran-Rojas A, Li L, Faraoni EY, White JR, Ajami N, Li L, Yadav D, Conwell DL, Serrano J, Pandol SJ, Fogel EL, Van Den Eden SK, Vege SS, Topazian MD, Park WG, Hart PA, Forsmark C, Bellin MD, Maitra A, Bhutani M, Kim M, Van Buren G 2nd, Fisher WE, McAllister F; on Behalf. Whole Metagenomic Profiling Identifies a Gut Microbial Signature for Chronic Pancreatitis via Machine Learning. Pancreas. 2026 Mar 30. doi: 10.1097/MPA.0000000000002618. Online ahead of print. PubMed PMID: 41910593.

Saloman JL, Andersen DK, Abu-El-Haija M, Bellin MD, Conwell DL, Faghih M, Forsmark CE, Goodarzi MO, Gulla AK, Hart PA, Hughes SJ, Kuo B, Ladd JM, Lee B, Pandol SJ, Phillips AE, Roberts KM, Schwarzenberg SJ, Singh VK, Summers RM, Tirkes T, Toledo FGS, Trikudanathan G, Uc A, Wasserfall CH, Whitcomb DC, Yadav D, Yost C, Zhang W, Freeman AJ. Complications of Pancreatitis-Knowledge Gaps and Research Opportunities: A Workshop Summary. Pancreas. 2026 Mar 1;55(3):e267-e277. doi: 10.1097/MPA.0000000000002574. PubMed PMID: 41668344.

Armah J, Alzahid S, Pei Q, Cousin L, Fanfan D, Heldermon C, Lyon D. Associations among physical activity, diet, non-lifestyle characteristics and the gut microbiome of cancer patients: A scoping review and network analysis. Oncoscience. 2026 Mar 11;13:85-103. doi: 10.18632/oncoscience.651. eCollection 2026. PubMed PMID: 41859194; PubMed Central PMCID: PMC12998689.

Cancer Targeting and Therapeutics

McKean J, Underwood P, Yasinzai AQK, George T, Sahin I, Fabregas J, Qumseya B, Novikov A, Chua T, Paniccia A, Hitchcock KE, Hughes S, Nassour I. Neoadjuvant Therapy for Localized Pancreatic Cancer. Cancers (Basel). 2026 Mar 20;18(6):1011. doi: 10.3390/cancers18061011. PubMed PMID: 41899612; PubMed Central PMCID: PMC13024805.

Molina Diaz BI, Zhuang P, Pan X, Doctsch G, He M. Engineering stimuli-responsive extracellular vesicles for enhanced anticancer therapeutics. Curr Opin Biomed Eng. 2026 Mar;37:100634. doi: 10.1016/j.cobme.2025.100634. Epub 2025 Dec 16. PubMed PMID: 41613407; PubMed Central PMCID: PMC12851582.

Henderson RH, Bryant CM, Nichols RC Jr, Mendenhall WM, Morris CG, Artz ME, Johnson PB, Balaji KC, Mendenhall NP. Ten-year outcomes for image-guided moderately hypofractionated proton therapy for prostate cancer. Radiother Oncol. 2026 Mar 8;219:111482. doi: 10.1016/j.radonc.2026.111482. Online ahead of print. PubMed PMID: 41806873.

Indelicato DJ, Buchanan AF, Chargari C, Fajardo RD, Fuchs J, Granberg CF, Martelli H, Passoni NM, Perkins SM, Smeulders N, Timmerman B, Routh JC. Local Control of Bladder/Prostate Rhabdomyosarcoma: An Expert Consensus Guideline From the International Soft Tissue Sarcoma Consortium (INSTRuCT). Pediatr Blood Cancer. 2026 Mar 13:e70183. doi: 10.1002/1545-5017.70183. Online ahead of print. PubMed PMID: 41823170.

Azari H, Moloudian H, Koopaei N, Sicard R, Ganey TM, Reynolds BA. Hemp-Derived Extracellular Vesicles: A Novel Frontier in Nanomedicine and Therapeutics. BioDrugs. 2026 Mar;40(2):197-214. doi: 10.1007/s40259-026-00766-0. Epub 2026 Mar 5. PubMed PMID: 41787227.

Abdullah M, Lee D, Nipa E, Castellanos-Gell J, Chan AM, Hernandez Maldonado O, Salute ME, Nance-Richey R, Milner RJ, Kim JH. Osteosarcoma cells promote intracellular iron detoxification to mitigate GPX4-mediated ferroptosis. Cancer Gene Ther. 2026 Mar 23. doi: 10.1038/s41417-026-01021-y. Online ahead of print. PubMed PMID: 41872463.

Duraivel S, Goodrich SL, Subramaniam V, Ross ME, Sumerlin BS, Angelini TE. Thermo-Transitioning Core-Shell Microgels Combine Cohesive Reinforcement and Noncohesive Reconfigurability to Enable 3D Bioprinting and Stabilize Tissues During Incubation. ACS Biomater Sci Eng. 2026 Mar 21. doi: 10.1021/acsbiomaterials.5c02038. Online ahead of print. PubMed PMID: 41863836.

Venkatesh A, Rodriguez Rosales RD, Kanumuambidi JP, Ishiyama Y, Al-Toubat M, Sceats H, Metzner TD, Sparks S, Murray N, Bandyk M, Balaji KC. Role of Spatial Heterogeneity in Muscle-Invasive Bladder Cancer on Overall Survival and Immunotherapy Response. Cancers (Basel). 2026 Mar 9;18(5):875. doi: 10.3390/cancers18050875. PubMed PMID: 41827808; PubMed Central PMCID: PMC12984956.

Milanovic S, Sun C, Gunnell L, Wilk V, Shinohara MM, Chang O, Admassu N, Chiu Y, Wanat KA, Young KE, Xu Y, Flaman AN, Nohr E, Motaparthi K. Beyond the Stain: BAP1-Inactivated Melanocytic Tumors With Retained BAP1 Nuclear Expression due to Missense Mutations in the Catalytic Domain. J Cutan Pathol. 2026 Mar 11. doi: 10.1111/cup.70086. Online ahead of print. PubMed PMID: 41813058.

Das R, Kleinberger J, Sawas T, Wald AI, Bubar R, Singh H, Chennat J, Khalid A, Romutis SL, Rabinovitz M, Tavakkoli A, Fairley KJ, Boone BA, Sarkaria S, Nasr J, Thiruvengadam NR, Gabbert C, Mahmood S, Messallam AA, Gjeorgjievski M, Goldschmiedt M, Thakkar S, Tielleman T, Dugum M, Reich J, Singh S, Brand RE, McGrath K, Fasanella K, Lennon AM, Reddy R, Shrestha R, Ellis DJ, Singhi SA, Lee T, Kay PS, Lee RD, Chua TY, Nassour I, Buxbaum JL, Law JK, Bhat Y, Jamidar PA, Jonica ER, Easler JJ, Skef W, Vanderveldt HD, Dasyam AK, Geller DA, Zureikat AH, Zeh HJ, Polanco PM, Marsh JW, Hogg M, Lee KK, Pingpank JF, Choudry MHA, Humar A, Schmidt C, Mansour J, Nunns G, Ongchin M, Paniccia A, Lajara S, Monaco SE, Ohori NP, Pantanowitz L, Mitchell JM, Smith K, Shaker N, Singhi AH, Hsu D, Saeed A, Sahin IH, Zhang J, Gorantla V, Rhee J, Nikiforova MN, Kubiliun N, Slivka A, Singhi AD. DNA/RNA-Based Next-Generation Sequencing (NGS) Improves the Early Diagnosis and Management of Neoplastic Bile Duct Strictures: A Six-Year, Prospective, Multi-Institutional, Real-Time Study. Gastroenterology. 2026 Mar 27:S0016-5085(26)00252-0. doi: 10.1053/j.gastro.2026.02.040. Online ahead of print. PubMed PMID: 41905432.

Li B, Parker J, Briggs S, Dong J, Wang C, Fu CW, Burke JM, Kodadek T. Macrocyclic Peptides Containing an Imidazopyridinium (IP+) Unit Display Enhanced Passive Cell Permeability. J Am Chem Soc. 2026 Mar 5. doi: 10.1021/jacs.5c17859. Online ahead of print. PubMed PMID: 41787884.

Jones E, Naranjo A, Winestone LE, Umaretiya PJ, Aziz-Bose R, Kelly CA, Newman H, Zheng DJ, Greengard E, Bagatell R, DuBois SG, Bona K. Collecting Social Determinants of Health in a Children’s Oncology Group Trial for High-Risk Neuroblastoma. JAMA Netw Open. 2026 Mar 2;9(3):e260419. doi: 10.1001/jamanetworkopen.2026.0419. PubMed PMID: 41770565; PubMed Central PMCID: PMC12954535.

Miyan J, Vudatha V, Cao L, Zhang P, Zheng G, Zheng L, Trevino J, Zhou D, Khan S. The Combination of a BCL-xL PROTAC and an mTOR Inhibitor Sensitizes Pancreatic Ductal Adenocarcinoma to KRASG12D Inhibitor Treatment. Cancers (Basel). 2026 Mar 12;18(6):920. doi: 10.3390/cancers18060920. PubMed PMID: 41899524; PubMed Central PMCID: PMC13025216.

Bankson JA, Niedzielski JS, Harlan CJ, Chen Y, Walker CM, Lorenzi PL, Tan L, Kundra V, Merritt ME, Ragavan M, Schellingerhout D, He R, Ding Y, Datar S, Wang Q, Peterson CB, Fuller CD, Sandulache VC, Lai SY. Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer. Magn Reson Med. 2026 Mar 24. doi: 10.1002/mrm.70351. Online ahead of print. PubMed PMID: 41876436.

Algarin Perneth S, Patel U, Ortiz Rocha A, Barb D, Acosta G, Srihari A, Dziegielewski P, Castro MR, Dean D, Ryder M, Hargraves I, Bylund C, Roy A, Zhang Z, Montori VM, Brito JP, Singh Ospina NM. Evaluation of a conversation aid for patients with thyroid nodules considering a biopsy: pilot multicenter randomized control trial. Endocrine. 2026 Mar 9;91(1):92. doi: 10.1007/s12020-025-04517-z. PubMed PMID: 41801576; PubMed Central PMCID: PMC12971928.

Armah J, Alzahid S, Pei Q, Cousin L, Fanfan D, Heldermon C, Lyon D. Associations among physical activity, diet, non-lifestyle characteristics and the gut microbiome of cancer patients: A scoping review and network analysis. Oncoscience. 2026 Mar 11;13:85-103. doi: 10.18632/oncoscience.651. eCollection 2026. PubMed PMID: 41859194; PubMed Central PMCID: PMC12998689.

Immuno-Oncology and Microbiome

Tasnim N, Jang Y. Protein Vesicles as Emerging Platforms for Drug Delivery, Vaccines, and Immunotherapy. Annu Rev Chem Biomol Eng. 2026 Mar 6. doi: 10.1146/annurev-chembioeng-100724-084456. Online ahead of print. PubMed PMID: 41791407.

Figg JW, Love C, Stansbury S, Jin D, Francis C, Dean BD, Reid A, Engelbart M, West I, Font LF, Feier D, Ebrahim G, Bessey R, Hilferty D, Yegorov O, Yang C, Long-James K, Mitchell DA, Flores CT. Adoptive cellular therapy prevents reconstitution of myeloid-derived suppressor cells in the glioma tumor microenvironment. Neurooncol Adv. 2026 Mar 7;8(1):vdag054. doi: 10.1093/noajnl/vdag054. eCollection 2026 Jan-Dec. PubMed PMID: 41908149; PubMed Central PMCID: PMC13019303.

Banson M, Lear G, Darko K, Moor RSF, Patel JA, Rahman M. Leveraging biometric data for meaningful outcome assessments in the care of patients with brain tumors: a systematic review. J Neurooncol. 2026 Mar 23;177(2):66. doi: 10.1007/s11060-026-05543-1. No abstract available. PubMed PMID: 41870686.

Dietz MS, Davis LE, Prasad PK, Campbell SR, Reith JD, Olsen MR, Kilpatrick SE, Ku JA, Silver NL, Park EP, Tirtei E, Meazza C, Murphy ES, Mallory NC, Palmerini E, Kager L, Hol MLF, van Ewijk R, Lopez J, Elliott LA, Shepard DR, Gupta A, Trucco MM. Consensus recommendations in the management of jaw (gnathic) osteosarcoma. Cancer. 2026 Mar 1;132(5):e70273. doi: 10.1002/cncr.70273. PubMed PMID: 41717876; PubMed Central PMCID: PMC12921839.

Mechanisms of Oncogenesis

Hong Y, Shekhar R, McMahon S, Keil N, Baddoo M, Watkins JM, Keshishian H, Stanclift C, Carr SA, Munschauer M, Burke JM, Flemington EK, Renne R. Herpesvirus-encoded lncRNA targets host splicing by interacting with splicing factors. PLoS Pathog. 2026 Mar 26;22(3):e1014072. doi: 10.1371/journal.ppat.1014072. Online ahead of print. PubMed PMID: 41886495.

Lee S-C, To M, Papp B, Boulant S, Toth Z. Stage-specific regulation of KSHV infection by HIF-1alpha. J Virol. 2026 Mar 10:e0004326. doi: 10.1128/jvi.00043-26. Online ahead of print. PubMed PMID: 41805195.

Wu SY, Tyagi A, Wu K, Smith EC, Song Q, Sharma S, Miller LD, Zhang W, Pan BS, Lin HK, Lee JS, Pullikuth A, Xing F, Deshpande RP, Zhao D, Liu Y, Kim JW, Soike MH, Ruiz J, Chan M, Chou J, Parson A, Watabe K. MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis. Nat Biomed Eng. 2026 Mar 2. doi: 10.1038/s41551-026-01613-x. Online ahead of print. PubMed PMID: 41772175.

Grimme AL, Li L, Scholl A, Donnelly BF, Channamraju N, Vieux KF, Zhou L, Seydoux G, Xie M, McJunkin K. A lncRNA drives developmentally timed decay of all members of an essential microRNA family. Genes Dev. 2026 Mar 6. doi: 10.1101/gad.353314.125. Online ahead of print. PubMed PMID: 41791866.

Aron M, Chandrashekar DS, Adulfatah E, Kunju LP, Zein-Sabatto B, Lobo J, Canete-Portillo S, Cox RM, Przybycin CG, Al-Obaidy K, Idrees MT, Falzarano SM, Wu AJ, Harada S, Netto GJ. Clinical and Molecular Characterization of Clear Cell Adenocarcinoma of the Urinary Tract: A Multi-Institutional Study. Am J Surg Pathol. 2026 Mar 4. doi: 10.1097/PAS.0000000000002527. Online ahead of print. PubMed PMID: 41775505.

Romano LE, Tsukagoshi S, Davey-Osuch EE, Ajredini R, Manasi K, Ortiz TV, Rijos E, Bourgon NJ, Ames SE, Garrett TJ, Cleary JD, Wang ET, Ranum LP. Metformin improves RAN protein pathology, alternative splicing, and behavioral phenotypes in SCA8 mice. Life Sci Alliance. 2026 Mar 2;9(5):e202503555. doi: 10.26508/lsa.202503555. Print 2026 May. PubMed PMID: 41771688; PubMed Central PMCID: PMC12954051.

Noor T, Schultz DC, Zhai Y, Snoke HE, Noh S, Seabra G, Lee RE, Jeong KC, Li C, Siddiqi AR. A virtual screening and molecular dynamics approach in search of novel antibiotic chemotypes. PLoS One. 2026 Mar 20;21(3):e0341835. doi: 10.1371/journal.pone.0341835. eCollection 2026. PubMed PMID: 41860821; PubMed Central PMCID: PMC13004388.