Recent publications from the UF Health Cancer Institute.
Cancer Control and Population Sciences
Yaghjyan L, Heng YJ, Sardella BR, Ratcliffe M, Rosner B, Tamimi RM. Associations of oral contraceptives with expression of CD44, CD24, and ALDH1A1 stem cell markers in women with benign breast biopsies. Breast Cancer Res. 2026 May 27. doi: 10.1186/s13058-026-02310-y. Online ahead of print. PubMed PMID: 42204640.
Freeman B, Bian T, Xu G, Wheeler M, Fujioka N, Malaty J, Orlando FA, Braithwaite D, Salloum RG, Bruijnzeel AW, Zhang W, Xing C. Assessing the Physiological Relevance of the Bioactivation of Tobacco Specific Carcinogen NNK and its Metabolite NNAL: Quantitative Analyses of Hydrolysis Products from Their Protein Adducts under Different Carcinogen Exposure Conditions. Carcinogenesis. 2026 May 17:bgag031. doi: 10.1093/carcin/bgag031. Online ahead of print. PubMed PMID: 42142878.
Masood S, Jamal M, Obukhau A, Smotherman C, Rashid T, Khan Z, Marji N. The promise of artificial intelligence in diagnostic breast pathology. Virchows Arch. 2026 May 12. doi: 10.1007/s00428-026-04578-z. Online ahead of print. PubMed PMID: 42118288.
Chellian R, Behnood-Rod A, Bruijnzeel AW. Progressive withdrawal-related reward deficits after nicotine self-administration in rats. Nicotine Tob Res. 2026 May 7:ntag096. doi: 10.1093/ntr/ntag096. Online ahead of print. PubMed PMID: 42096517.
Kim HJ, Kim S, Torres C, Sim W, Fillingim RB. Beliefs about pain and lived experience of chronic pain among Korean Americans in the community: A qualitative study. J Pain. 2026 May 3;44:106306. doi: 10.1016/j.jpain.2026.106306. Online ahead of print. PubMed PMID: 42086098; PubMed Central PMCID: PMC13218180.
Fan Z, Liang R, Sun C, Pan J, Terry R, Xu J. Multimodal Prediction of Renal Tumor Malignancy From Radiology Reports and Structured Electronic Health Records: Retrospective Cohort Study. JMIR Med Inform. 2026 May 27;14:e84396. doi: 10.2196/84396. PubMed PMID: 42202288.
Shin B, Choi C, Dawson RJ, Hyeong Kim C, Bolch WE. Tooth enamel dose coefficients of the ICRP adult mesh-type reference computational phantoms for idealized external neutron exposures. J Radiol Prot. 2026 May 5;46(2). doi: 10.1088/1361-6498/ae6080. PubMed PMID: 41990760.
Shin B, Griffin K, Choi C, Yeom YS, Kim CH, Bolch WE. DOSE COEFFICIENTS FOR THE ICRP PREGNANT-FEMALE MESH-TYPE REFERENCE COMPUTATIONAL PHANTOMS UNDER IDEALIZED EXTERNAL EXPOSURES TO PHOTONS. J Radiol Prot. 2026 May 21. doi: 10.1088/1361-6498/ae7121. Online ahead of print. PubMed PMID: 42167280.
Shin B, Choi C, Yeom YS, Kim CH, Bolch WE. Dose Coefficients for Irradiation of Tooth Enamel within ICRP Adult Mesh-type Reference Computational Phantoms for Idealized External Photon Exposures. Health Phys. 2026 May 1;130(5):588-597. doi: 10.1097/HP.0000000000002068. Epub 2026 Feb 27. PubMed PMID: 41770105.
Lin Y, Zeidan RS, Ghaderpanah R, Ohama MK, Jung MH, Baskaran N, Delgado JS, Anton SD, Smith BK, Leeuwenburgh C, Hsu FC, Efron PA, Buford TW, Flynn S, Guirgis FW, Mankowski RT. Feasibility of home-based, remotely delivered exercise training to improve physical function in older sepsis survivors: a pilot randomized controlled trial. Geroscience. 2026 May 21. doi: 10.1007/s11357-026-02328-2. Online ahead of print. PubMed PMID: 42168725.
Ahmed SB, Becker JB, Bruno KA, Dumanski SM, Galea LAM, Kundakovic M, Raznahan A, Tronson NC, Cunningham RL. Twenty years of sex and gender science in health research: a policy statement from the Organization for the Study of Sex Differences. Biol Sex Differ. 2026 May 12;17(1):85. doi: 10.1186/s13293-026-00894-w. PubMed PMID: 42115910; PubMed Central PMCID: PMC13162465.
Lteif C, Myers RA, Elwood EN, Harris EC, Chakraborty H, Dexter PR, Peterson JF, Rider R, Skaar TC, Volpi S, Johnson JA, Duarte JD, Cavallari LH. CYP2D6 phenotype and post-surgical pain control with hydrocodone and oxycodone. Front Pharmacol. 2026 May 11;17:1817652. doi: 10.3389/fphar.2026.1817652. eCollection 2026. PubMed PMID: 42199863; PubMed Central PMCID: PMC13199760.
Li E, Bian T, Finkelberrg M, Liu Z, Bi Z, Carlson D, Xing C, Yang C, Wang Z. AB-Free Kava and Dihydromethysticin Inhibit Chronic Hexavalent Chromium Exposure-Induced Cell Malignant Transformation through Down-Regulating RNA Splicing Factor SNRPA1 Expression. Chem Res Toxicol. 2026 May 14. doi: 10.1021/acs.chemrestox.6c00147. Online ahead of print. PubMed PMID: 42135982.
Beishembieva N, Gorman B, Paul AS, Velickovic M, Velickovic D, Clair G, Sharma K, Sarder P, Anderton CR; Kidney Precision Medicine Project. AI-Based Digital Pathology-Enabled Spatial-Omics Data Analyses of the Human Kidney. J Proteome Res. 2026 May 15. doi: 10.1021/acs.jproteome.6c00147. Online ahead of print. PubMed PMID: 42139323.
Aung KZ, Nelson PT, Ning X, Wu X, Tsuchiya I, Karanth S, Abner EL, Fardo DW, Katsumata Y. GRN rs5848 variant associates with TDP-43 pathology and cancer in opposite directions. J Neuropathol Exp Neurol. 2026 May 21:nlag051. doi: 10.1093/jnen/nlag051. Online ahead of print. PubMed PMID: 42168777.
Boatman D, Gibbs BB, Cottrell L, Pilkerton C, Bylund C, Watson M, Starkey A, Kennedy-Rea S. From conversation to completion: identifying conversation elements to support effective shared decision-making for lung cancer screening in rural primary care. BMC Prim Care. 2026 May 14. doi: 10.1186/s12875-026-03366-7. Online ahead of print. PubMed PMID: 42129655.
Moll M, Mendenhall NP, Goldner G, Miszczyk M, Sushant S, Lutgendorf-Caucig C, Hug E, Mendenhall WM. Perirectal spacers and endorectal balloons in external beam radiotherapy for prostate cancer: a review of prospective studies. Strahlenther Onkol. 2026 May 22. doi: 10.1007/s00066-026-02545-w. Online ahead of print. PubMed PMID: 42171762.
Sparrock LS, Vidrine JI, Vinci CE, El Naqa IM, Sutton SK, Salloum RG, Dallery J, Crane TE, Penedo FJ, Brockway SJ, Jones SR, Hoogland CE, Reich RR, Gonzalez-Calderon G, Simmons VN, Vidrine DJ. Creation of an mHealth Infrastructure to Support the Development and Delivery of mHealth Interventions: Protocol for Demonstration Projects Addressing Smoking Cessation in Cancer Care. JMIR Res Protoc. 2026 May 29;15:e92288. doi: 10.2196/92288. PubMed PMID: 42214073.
Cancer Targeting and Therapeutics
Vander Kooi CW, Gentry MS, Sun RC. Shaping Human Health and Nutrition Through Innovations in Spatial Metabolism. Annu Rev Nutr. 2026 May 19. doi: 10.1146/annurev-nutr-062024-111053. Online ahead of print. PubMed PMID: 42154815.
Ducharme JB, Ebert SM, Cameron ME, Schonk MM, Callaway CS, D’Lugos AC, Talley JJ, Judge SM, Adams CM, Judge AR. Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia. Am J Physiol Cell Physiol. 2026 May 12. doi: 10.1152/ajpcell.00159.2026. Online ahead of print. PubMed PMID: 42117587.
Kim C, Zhu Z, Tagmount A, Barbazuk WB, Bacher R, Vulpe CD. Physiologically relevant 3D CRISPR screening enhances mechanistic insight into chemical toxicity compared to 2D screening. Toxicology. 2026 May;522:154422. doi: 10.1016/j.tox.2026.154422. Epub 2026 Feb 3. PubMed PMID: 41643803; PubMed Central PMCID: PMC13185028.
Smith E, Parker JK, Fayos IG, Stan NR, Scampavia L, Kodadek T, Spicer TP. A high throughput assay to identify modulators of Death Receptor 3 (DR3). SLAS Discov. 2026 May 5;41:100312. doi: 10.1016/j.slasd.2026.100312. Online ahead of print. PubMed PMID: 42097330.
Moll M, Mendenhall NP, Goldner G, Miszczyk M, Sushant S, Lutgendorf-Caucig C, Hug E, Mendenhall WM. Perirectal spacers and endorectal balloons in external beam radiotherapy for prostate cancer: a review of prospective studies. Strahlenther Onkol. 2026 May 22. doi: 10.1007/s00066-026-02545-w. Online ahead of print. PubMed PMID: 42171762.
Lteif C, Myers RA, Elwood EN, Harris EC, Chakraborty H, Dexter PR, Peterson JF, Rider R, Skaar TC, Volpi S, Johnson JA, Duarte JD, Cavallari LH. CYP2D6 phenotype and post-surgical pain control with hydrocodone and oxycodone. Front Pharmacol. 2026 May 11;17:1817652. doi: 10.3389/fphar.2026.1817652. eCollection 2026. PubMed PMID: 42199863; PubMed Central PMCID: PMC13199760.
Scoggins Iv TR, Brydon SC, Long JOT, Zerebinski P, Blanksby SJ, Prentice BM. Ozonolysis of Strontium-Adducted Phosphatidylcholines in the Gas Phase: Expanding the Isomeric Coverage of Ozone-Induced Dissociation. J Am Soc Mass Spectrom. 2026 May 14. doi: 10.1021/jasms.6c00087. Online ahead of print. PubMed PMID: 42136205.
Douglas CJ, Seath CP. Chemical biology tools for studying histone post-translational modifications. Cell Chem Biol. 2026 May 26:S2451-9456(26)00150-9. doi: 10.1016/j.chembiol.2026.04.015. Online ahead of print. PubMed PMID: 42190662; PubMed Central PMCID: PMC13218614.
Taggart DJ, Mahajan S, Gallant MA, Pinkoviezky I, Xu J, Sorg AJ, Roberts CC, Slinkov D, Gorospe EC, Mubarak A, Bhandari BR, Freilich B, Gunn N, Yang JD, Smith JH, Younes ZH, Cabrera R, Aguilar H, Samant H, Li W, Van Etten RA, Nguyen MH. A Multi-Analyte cfDNA-based Blood Test for Early Detection of Hepatocellular Carcinoma. J Hepatol. 2026 May 6:S0168-8278(26)00215-1. doi: 10.1016/j.jhep.2026.04.012. Online ahead of print. PubMed PMID: 42102976.
Shao D, Malave JG, Rossi JS, Franchi F, Keeley EC, Angiolillo DJ, Stouffer GA, Cavallari LH, Lee CR. Impact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention. Clin Pharmacol Ther. 2026 May 15. doi: 10.1002/cpt.70338. Online ahead of print. PubMed PMID: 42138382.
Zaman KAU, Petriti V, Dhakal D, Sarotti AM, Yan C, Wu X, Wu Z, Jiang Y, Rubin GM, Turkson J, Zheng G, Ding Y, Cao S. Fusaric Acid Analogs and Dimers from Marine-Derived Fusarium sp.: Biosynthetic Insights and Chloramphenicol-Enhanced Antibacterial Activity. J Nat Prod. 2026 May 19:10.1021/acs.jnatprod.6c00288. doi: 10.1021/acs.jnatprod.6c00288. Online ahead of print. PubMed PMID: 42153971; PubMed Central PMCID: PMC13188348.
Freeman B, Bian T, Xu G, Wheeler M, Fujioka N, Malaty J, Orlando FA, Braithwaite D, Salloum RG, Bruijnzeel AW, Zhang W, Xing C. Assessing the Physiological Relevance of the Bioactivation of Tobacco Specific Carcinogen NNK and its Metabolite NNAL: Quantitative Analyses of Hydrolysis Products from Their Protein Adducts under Different Carcinogen Exposure Conditions. Carcinogenesis. 2026 May 17:bgag031. doi: 10.1093/carcin/bgag031. Online ahead of print. PubMed PMID: 42142878.
Tran E, St Pierre L, Velarde D, Dal Bo B, Alvarez JR, Ofosu-Asante K, Lamango NS, Huang Y, Marconett CN, Borok Z, Zhou B, Offringa IA. Immortalization of Human Adult Alveolar Epithelial Cells to Study Environmental Exposures of the Distal Lung. Curr Protoc. 2026 May;6(5):e70372. doi: 10.1002/cpz1.70372. PubMed PMID: 42059385; PubMed Central PMCID: PMC13130368.
Immuno-Oncology and Microbiome
Albao DS, Nagaraja SD, Pipkin ME. A Kruppel of factors regulate T cell residency and exhaustion. Immunity. 2026 May 12;59(5):1168-1170. doi: 10.1016/j.immuni.2026.04.007. PubMed PMID: 42119364.
Lightsey S, Kates HR, Shirlekar K, Brant JO, Sharma B. A Defined 3D Hydrogel Model Recapitulates Key Transcriptomic Features of Lung Adenocarcinoma. Tissue Eng Part C Methods. 2026 May;32(5):195-207. doi: 10.1177/19373384261448311. Epub 2026 May 23. PubMed PMID: 42175837.
Cusatis R, Kou J, Bupp C, Mattila D, Abboud R, Arai S, Bolanos Meade J, Carrum G, Dholaria B, Fareh F, Hamadani M, Hogan WJ, Jamieson K, Jimenez Jimenez AM, Khimani F, Kelkar AH, Kosuri S, Larkin KT, Al Malki MM, McCurdy SR, Milner J, Modi D, Reshef R, Shaffer BC, Shanmugasundaram K, Rao U, Auletta JJ, Devine SM, Logan BR, Shaw BE. Hematopoietic Cell Transplant Access and Patient Diversity. JAMA Netw Open. 2026 May 1;9(5):e2610839. doi: 10.1001/jamanetworkopen.2026.10839. PubMed PMID: 42084866; PubMed Central PMCID: PMC13147192.
Evans EM, Mayday MY, Pearce EM, Iwanaga K, Ly NP, Church GD, Reyes G, Simon MR, Blum J, Kim H, Mu J, Baez-Maidana J, Auletta JJ, Shaw PJ, Kreml EM, Martin PL, Duncan CN, Rowan CM, Godder K, Hurley C, Cuvelier GDE, Qayed M, Abdel-Azim H, Keating AK, Fitzgerald JC, Hanna R, Killinger JS, Hume JR, Quigg TC, Castillo P, Satwani P, Moore TB, Dvorak CC, Zinter MS; Pediatric Transplantation And Cell Therapy Consortium. Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell Transplantation. Am J Respir Cell Mol Biol. 2026 May 19:aanag106. doi: 10.1093/ajrcmb/aanag106. Online ahead of print. PubMed PMID: 42150759.
Wang T, Yang X, Lee Y, Song JH, Childs-Disney JL, Garcia JGN, Disney MD. Small-Molecule Degradation of the MicroRNA-21 Precursor Rescues Pathogenic Pathways in Cellular Models of Fibrosis. ACS Chem Biol. 2026 May 18. doi: 10.1021/acschembio.5c00979. Online ahead of print. PubMed PMID: 42149896.
Bhat A, Arham M, Ali Z, Ishtiaq S, Abdul Rehman M, Ahmed A, Chauhan A, Tareen HK, Bakht K, Haider F, Dad A, Creech L, Novikov A, Draganov PV. Endoscopic Ultrasound-Guided Franseen Fine-Needle Biopsy for Solid Pancreatic Lesions: A Systematic Review and Meta-Analysis. Dig Dis Sci. 2026 May 19. doi: 10.1007/s10620-026-09970-y. Online ahead of print. PubMed PMID: 42156629.
Omer L, Gloude NJ, McGuinn C, Nakano TA, Overholt K, Ogando-Rivas E, Myers KC, Broglie LA, Hillier K, Schaefer E, Rothman JA, Goteti S, Dror Y, Cancio MI, Contreras Yametti GP, Cada M, Shimano KA, Allen SW, Lipton JM, Kurre P, Castillo P, de Jong JLO. A Survey of Provider Practices for Diagnosis and Treatment of Pediatric Moderate Aplastic Anemia From the North American Pediatric Aplastic Anemia Consortium. J Pediatr Hematol Oncol. 2026 May 15. doi: 10.1097/MPH.0000000000003209. Online ahead of print. PubMed PMID: 42154490.
Mechanisms of Oncogenesis
Orosco C, Huang B, Rananaware SR, Bodin AP, Browning I, Fang A, Baugh MP, Lange IH, Elhabashy YB, Balaraju M, Lewis JG, Shah NH, Hanna MP, Flannery SJ, Meister KS, Karalkar V, Jain PK. DNA-guided CRISPR-Cas12 for cellular RNA targeting. Nat Biotechnol. 2026 May 15. doi: 10.1038/s41587-026-03129-w. Online ahead of print. PubMed PMID: 42141118.
Li L, Sheng P, Hiers NM, Li T, Grimme AL, Wang Y, Traugot CM, D’Agati OM, Xie M. CLASHub is an integrated database and analytical platform for microRNA-target interactions. Nat Commun. 2026 May 8. doi: 10.1038/s41467-026-72902-x. Online ahead of print. PubMed PMID: 42098137.
Nelson TS, Pacini C, Nguyen A, Zeigler TM, Ziff A, Paulsen K, Simpson A, Bhaduri-McIntosh S, Ma Z. STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma. Front Immunol. 2026 May 5;17:1823240. doi: 10.3389/fimmu.2026.1823240. eCollection 2026. PubMed PMID: 42164483; PubMed Central PMCID: PMC13183639.
Daigle D, Creasy-Marrazzo A, Gradoville L, El-Guindy A, Mukherjee R, Das S, Baral B, Rousseau BA, Park R, McIntosh MT, Miller G, Bhaduri-McIntosh S. Playing both sides – Epstein-Barr Virus accumulates select cellular transcripts to counter virus-mediated host shut-off in lytic cells. PLoS Pathog. 2026 May 11;22(5):e1014211. doi: 10.1371/journal.ppat.1014211. Online ahead of print. PubMed PMID: 42113877.
Wang T, Yang X, Lee Y, Song JH, Childs-Disney JL, Garcia JGN, Disney MD. Small-Molecule Degradation of the MicroRNA-21 Precursor Rescues Pathogenic Pathways in Cellular Models of Fibrosis. ACS Chem Biol. 2026 May 18. doi: 10.1021/acschembio.5c00979. Online ahead of print. PubMed PMID: 42149896.
Vander Kooi CW, Gentry MS, Sun RC. Shaping Human Health and Nutrition Through Innovations in Spatial Metabolism. Annu Rev Nutr. 2026 May 19. doi: 10.1146/annurev-nutr-062024-111053. Online ahead of print. PubMed PMID: 42154815.
Kim C, Zhu Z, Tagmount A, Barbazuk WB, Bacher R, Vulpe CD. Physiologically relevant 3D CRISPR screening enhances mechanistic insight into chemical toxicity compared to 2D screening. Toxicology. 2026 May;522:154422. doi: 10.1016/j.tox.2026.154422. Epub 2026 Feb 3. PubMed PMID: 41643803; PubMed Central PMCID: PMC13185028.
Hauns S, Pinto FG, Khyriem C, Singh A, Al-Sadi A, Yazeedi TA, Mohammad R, Cisse B, Garrett TJ, Uddin M, Soares NC, Backofen R, Alkhnbashi OS. Autoencoder/RandomForest-TabPFN for Cross-Cancer Metabolomics: Prostate and Breast Cancer Diagnosis Using Paper Spray and Ion Mobility-Mass Spectrometry Techniques. Gigascience. 2026 May 7:giag053. doi: 10.1093/gigascience/giag053. Online ahead of print. PubMed PMID: 42096511.
Filipponi C, Bloom DC, Gambotto C, Wallace CT, Milosevic J, Watkins SC, Buckley S, Wesesky MA, Nimgaonkar VL, D’Aiuto L. Dynamics of Paraspeckle Components in Herpes Simplex Virus 1 (HSV-1)-Infected Human Neuronal Cells. Viruses. 2026 May 12;18(5):552. doi: 10.3390/v18050552. PubMed PMID: 42198755; PubMed Central PMCID: PMC13211404.
Freeman B, Bian T, Xu G, Wheeler M, Fujioka N, Malaty J, Orlando FA, Braithwaite D, Salloum RG, Bruijnzeel AW, Zhang W, Xing C. Assessing the Physiological Relevance of the Bioactivation of Tobacco Specific Carcinogen NNK and its Metabolite NNAL: Quantitative Analyses of Hydrolysis Products from Their Protein Adducts under Different Carcinogen Exposure Conditions. Carcinogenesis. 2026 May 17:bgag031. doi: 10.1093/carcin/bgag031. Online ahead of print. PubMed PMID: 42142878.
Lightsey S, Kates HR, Shirlekar K, Brant JO, Sharma B. A Defined 3D Hydrogel Model Recapitulates Key Transcriptomic Features of Lung Adenocarcinoma. Tissue Eng Part C Methods. 2026 May;32(5):195-207. doi: 10.1177/19373384261448311. Epub 2026 May 23. PubMed PMID: 42175837.
