- Aim 1. Elucidate molecular, behavioral, and other risk factors in cancer incidence and mortality by conducting population-based research.
CCPS Research focuses on risk factor quantification across observational studies, particularly those related to molecular and behavioral risk factors (e.g., the mechanistic target of rapamycin [mTOR] at the nexus of nutritional status, metabolism, aging and cancer; the role of behavioral risk factors, including tobacco use, and pulmonary status), with a focus on underserved populations in our catchment area.
- Aim 2. Develop and implement evidence-based primary and secondary cancer prevention interventions to reduce the cancer burden.
Informed by observational studies in Aim 1, CCPS research focuses on accelerating development and implementation of behavioral interventions to reduce the prevalence of risk factors and optimize early detection through efficacy, effectiveness, and pragmatic trials.
- Aim 3. Address the unique needs of cancer survivors, especially among our underserved communities.
Research undertaken by CCPS members spans observational and interventional methods to meet critical needs of cancer survivors, with a focus on reducing geographic, economic, racial/ethnic, and age-related disparities in outcomes in our catchment area and nationally.
To achieve these aims, The impact is achieved via cross-cutting: 1) use of innovative technology, strategic message design, and large data science; and 2) enhancement of cultural sensitivity to reduce cancer health disparities. Through the conduct of clinical trials and comparative effectiveness research in real–world settings, CCPS members develop, test and assess interventions to reduce treatments toxicities, and improve symptom management, palliative care, and quality of life. CCPS members also are developing and testing strategies to link tumor registry, EHR, genomic, vital statistics, census and environmental data to identify factors contributing to disparities in cancer prevention, screening and treatment and to develop interventions to address those factors.