The UF Health Cancer Center serves more than 2.1 million residents across 23 counties of North and Central Florida, spanning about 17,500 square miles, about the size of Southern New England.

Most of the counties (16) are rural and every county is classified as a medically underserved area. The population includes people who are Black (15%), Hispanic (12%), and has the highest fraction (24%) of residents aged 65 years or older in Florida.
Through community outreach, the UF Health Cancer Center supports efforts to increase health literacy, prevention, screening, and research engagement.