Here is a look at the accomplishments of TICaRT trainees to date.
2023-25 Cohort
UF College of Medicine 2024 Celebration of Research
Outstanding Poster Award in Basic & Translational Sciences – Postdoctoral Category 2024
Jordan McKean, M.D.
Leptin Expression and Cachexia in Pancreatic Ductal Adenocarcinoma
UF Health Cancer Center Predoctoral Awardees:
- Madison Carelock: 2023 UF Health Cancer Center Predoctoral Awardee
TICaRT Posters: 2024 Research Showcase
(*Presenting author)
Carelock ME*, Zhang P, Jiao M, Umasankar D, Jin Z, Stump RM, Williams SG, Zheng G, Zhang W
Attenuating breast cancer metastasis with BCL-XL-targeting PROTACs
Ducharme JB*, Schonk MM, Al-Zaeed NM, Gutierrez-Monreal MA, Esser KA, Judge SM, Judge AR
Pancreatic cancer disrupts the skeletal muscle molecular clock in a FoxP1-dependent manner
Smith AR*, Wu Z, Nar R, Li Y, Qian Z, Zheng G
PROTAC-induced degradation to target aberrant m6A mRNA modifications in acute myeloid leukemia
Freeman B*, Salloum RG, Malaty J, Orland, F, Huo Z, Xing C
Potential of kava in reducing lung cancer risk and associated disparities – mechanism-based biomarker discovery and analysis
McKean J*, Riner A, Tushoski G, Neal D, Herremans K, Han S, Hughes S
Leptin expression and cachexia in pancreatic ductal adenocarcinoma
Wheeler M*, Freeman B, Yoon HS, Huo Z, Xing C, Braithwaite D
Optimizing lung cancer risk assessment: from bench to trench
Ducharme JB, Carelock ME*, Schonk MM, Al-Zaeed NM, Zhang W, Judge SM, Judge AR
Cell type-specific senescence program in skeletal muscle of mice with pancreatic cancer
TICaRT Presentations:
2024 Cancer Research Conference for Science Teachers
Jeremy Ducharme, Ph.D. & Madison Carelock
Utilizing chimeras to reverse therapy-induced cachexia
2021-23 Cohort
UF College of Medicine 2024 Celebration of Research
Oberndorf Clinical Artificial Intelligence Scholars Award
Daniel Stribling
A Prototype Model for the Personalized Prediction of Pro-oncogenic MicroRNA Targeting & Gene Regulatory Network Dysregulation
UF Health Cancer Center Predoctoral Awardees:
- Nicholas Hiers: 2023 UF Health Cancer Center Predoctoral Awardee
- Rachel Newsome: 2021 UF Health Cancer Center Predoctoral Awardee
- Daniel Stribling: 2021 UF Health Cancer Center Predoctoral Awardee
TICaRT Posters: 2023 Research Showcase
(*Presenting author)
Cooks EJ*, Chen X, Vilaro MJ, Lok B, Krieger JL.
The influence of information overload during interactions with a virtual clinician: message processing as a mechanism to understand colorectal cancer screening intentions
DiVita Dean B*, Wildes T, Dean J, Yegorov O, Yang C, Shin D, Francis C, Sebastian M, Figg J, Falceto Font L, Moore G, Fernandez B, Wummer B, Kuizon C, Mitchell D, Flores C
Adoptive cellular therapy reverses glioma-driven dysfunction of immune system homeostasis
Hiers N*, Stribling D*, Xie M, Renne R
Quantitative CLASH (QtCLASH) Analysis of miRNA Targeting in Colorectal Cancer
Leas DA*, Abboud KA, Huigens III RW
Synthesis of Complex and Diverse Compounds from Oxidative Cleavage of Indole Alkaloids and Derivatives
Newsome RC*, Oh J, Jian W, Gharaibeh RZ, Crawford J, Jobin C
A bacterial consortium engineered from feces of patients responding to anti-PD1 treatment mediates tumor response through IFNγ in non-small cell lung cancer
TICaRT Presentations
2023 Cancer Research Symposium for High School Students
Eric Cooks, Ph.D. & Andrew Maxim
Virtual Human Customization
2023 Cancer Research Symposium for High School Students
Bayli DiVita Dean, Ph.D. & Rachel Newsome
The Microbiome, Immunotherapy & Pansolid Tumors
2022 Cancer Research Conference for Science Teachers
Eric Cooks, Ph.D. & Andrew Maxim
TICaRT T32: Virtual Human Customization
Career Outcomes
| TRAINEE NAME | TICaRT position | cURRENT Position |
|---|---|---|
| Eric Cooks, Ph.D. | Postdoctoral Fellow,2021-2023 Cohort | Senior Program Director,Leukemia & Lymphoma Society |
| Peter Dib, Ph.D | Predoctoral Fellow,2021-2023 Cohort | Field Applications Scientist,Spectral Instruments Imaging |
| Bayli DiVita Dean, Ph.D. | Postdoctoral Fellow,2021-2023 Cohort | Marketing & Communications Manager,American Brain Tumor Association |
| Derek Leas, Ph.D. | Predoctoral Fellow,2021-2023 Cohort | Synthetic Chemist, GeneTools |
| Rachel Newsome, Ph.D. | Predoctoral Fellow,2021-2023 Cohort | Postdoctoral Associate,University of Florida |
| Daniel Stribling, Ph.D. | Predoctoral Fellow,2021-2023 Cohort | MD training (Part 2), University of Florida |
Publications
- Cooks EJ, Duke KA, Neil JM, Vilaro MJ, Wilson-Howard D, Modave F, George TJ, Odedina FT, Lok BC, Carek P, Laber EB, Davidian M, Krieger JL. Telehealth and racial disparities in colorectal cancer screening: A pilot study of how virtual clinician characteristics influence screening intentions. J Clin Transl Sci. 2022 Apr 8;6(1):e48. doi: 10.1017/cts.2022.386. PMID: 35619640; PMCID: PMC9108377.
- Cooks EJ, Duke KA, Flood-Grady E, Vilaro MJ, Ghosh R, Parker N, Te P, George TJ, Lok BC, Williams M, Carek P, Krieger JL. Can virtual human clinicians help close the gap in colorectal cancer screening for rural adults in the United States? The influence of rural identity on perceptions of virtual human clinicians. Prev Med Rep. 2022 Oct 28;30:102034. doi: 10.1016/j.pmedr.2022.102034. PMID: 36531088; PMCID: PMC9747643.
- Cooks EJ, Vilaro MJ, Dyal BW, Wang S, Mertens G, Raisa A, Kim B, Campbell-Salome G, Wilkie DJ, Odedina F, Johnson-Mallard V, Yao Y, Krieger JL. What did the pandemic teach us about effective health communication? Unpacking the COVID-19 infodemic. BMC Public Health. 2022 Dec 13;22(1):2339. doi: 10.1186/s12889-022-14707-3. PMID: 36514047; PMCID: PMC9747260.
- Vilaro MJ, Bryan E, Palani T, Cooks EJ, Mertens G, Zalake M, Lok BC, Krieger JL. Rural adults’ perceptions of nutrition recommendations for cancer prevention: Contradictory and conflicting messages. Prev Oncol Epidemiol. 2023;1(1):2237680. doi: 10.1080/28322134.2023.2237680. Epub 2023 Nov 17. PMID: 38390218; PMCID: PMC10883477.
- Maria Guijarro, Patrick Kellish, Peter Dib, Nicholas Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicolas Borrero, Carlos Modenutti, Richard Bennett, Daniil Shabashvili, Jonathan Licht, Robert McKenna, Adrian Roitberg, Robert Huigens III, Frederic Kaye, and Maria Zajac-Kaye. Discovery of a first-in-class multifunctional TYMS non- classical antifolate inhibitor with potent in vivo activity that prolongs survival. JCI Insight 2023, 8, e158798. PMID: 37097751; PMCID: PMC10386886. DOI: 10.1172/jci.insight.158798.
- Maria Guijarro, Akbar Nawab, Peter Dib, Sandra Burkett, Xiaoping Luo, Michael Feely, Elham Nasri, Robert P. Seifert, Frederic J. Kaye and Maria Zajac-Kaye. TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background – Oncogene 2023, 42, :1926–1939. PMID: 37106126; PMCID: PMC10244171. DOI: 10.1038/s41388-023-02694-7.
- DiVita Dean B, Wildes T, Dean J, Yegorov O, Yang C, Shin D, Francis C, Figg JW, Sebastian M, Font LF, Jin D, Reid A, Moore G, Fernandez B, Wummer B, Kuizon C, Mitchell D, Flores CT. Immunotherapy reverses glioma-driven dysfunction of immune system homeostasis. J Immunother Cancer. 2023 Feb;11(2):e004805. doi: 10.1136/jitc-2022-004805. PMID: 36750252; PMCID: PMC9906384.
- Li L, Sheng P, Li T, Fields CJ, Hiers NM, Wang Y, Li J, Guardia CM, Licht JD, Xie M. Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins. Genes Dev. 2021 Dec 1;35(23-24):1595-1609. doi: 10.1101/gad.348874.121. Epub 2021 Nov 24. PMID: 34819352; PMCID: PMC8653786.
- Sheng P, Li L, Li T, Wang Y, Hiers NM, Mejia JS, Sanchez JS, Zhou L, Xie M. Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA’s role in regulating miR-999. Nat Commun. 2023 Apr 13;14(1):2108. doi: 10.1038/s41467-023-37819-9. PMID: 37055443; PMCID: PMC10102002.
- Fields CJ, Li L, Hiers NM, Li T, Sheng P, Huda T, Shan J, Gay L, Gu T, Bian J, Kilberg MS, Renne R, Xie M. Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a. PLoS Genet. 2021 Dec 16;17(12):e1009934. doi: 10.1371/journal.pgen.1009934. PMID: 34914716; PMCID: PMC8675727.
- Leas DA, Schultz DC, Huigens RW 3rd. Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery. SynOpen. 2023 Jun;7(2):165-185. doi: 10.1055/a-2048-8412. Epub 2023 May 11. PMID: 37795132; PMCID: PMC10549995.
- Newsome RC, Gharaibeh RZ, Pierce CM, da Silva WV, Paul S, Hogue SR, Yu Q, Antonia S, Conejo-Garcia JR, Robinson LA, Jobin C. Interaction of bacterial genera associated with therapeutic response to immune checkpoint PD-1 blockade in a United States cohort. Genome Med. 2022 Mar 29;14(1):35. doi: 10.1186/s13073-022-01037-7. PMID: 35346337; PMCID: PMC8961902.
- Newsome R, Jobin C. Finding clues in unexpected places: detection of pancreatic cancer through the faecal microbiome. Gut. 2022 Jul;71(7):1247-1248. doi: 10.1136/gutjnl-2021-326710. Epub 2022 Mar 8. PMID: 35260443; PMCID: PMC9177648.
- Newsome R, Yang Y, Jobin C. Western diet influences on microbiome and carcinogenesis. Semin Immunol. 2023 May;67:101756. doi: 10.1016/j.smim.2023.101756. Epub 2023 Apr 3. PMID: 37018910.
- Newsome RC, Yang Y, Jobin C. The microbiome, gastrointestinal cancer, and immunotherapy. J Gastroenterol Hepatol. 2022 Feb;37(2):263-272. doi: 10.1111/jgh.15742. Epub 2021 Dec 3. PMID: 34820895; PMCID: PMC9922516.
- Stribling D, Gay LA, Renne R. Hybkit: a Python API and command-line toolkit for hybrid sequence data from chimeric RNA methods. Bioinformatics. 2023 Dec 1;39(12):btad721. doi: 10.1093/bioinformatics/btad721. PMID: 38006335; PMCID: PMC10701094.
- Stribling D, Xia Y, Amer MK, Graim KS, Mulligan CJ, Renne R. The model student: GPT-4 performance on graduate biomedical science exams. Sci Rep. 2024 Mar 7;14(1):5670. doi: 10.1038/s41598-024-55568-7. PMID: 38453979; PMCID: PMC10920673.
