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Facilities & Resources
The University of Florida (UF) is a world leader in interdisciplinary research. The UF Health Cancer Center, UF Genetics Institute, UF Interdisciplinary Center for Biotechnology Research, UF Emerging Pathogens Institute, and the College of Medicine are designed to create synergies and collaborative research opportunities that focus on the translational nature of biomedical research, following the continuum from fundamental research to clinical research to patient care. These entities are poised to contribute to the success of this project by providing the highest intellectual and physical resources. UF, its Health Science Center, and its six Colleges, and nine Institutes are committed to providing an exceptional environment for the training of future leaders in the health sciences.
The UF Health Cancer Center (UFHCC) is part of UF’s Health Science Center, one of the most comprehensive academic medical centers in the southeastern United States and located on the campus of the University of Florida – a top-20 public research university. The Center’s membership is comprised of more than 250 researchers and clinicians drawn from 2 campuses, 11 colleges, 72 departments, 2 major teaching hospitals – Shands Gainesville and Jacksonville – and the nation’s largest Veterans Administration hospital, the Malcom Randall VA Medical Center in Gainesville.
The UFHCC is dedicated to:
- providing state-of-the-art cancer treatment, prevention, control, and education to individuals of diverse races and ethnicities;
- conducting original scientific research aimed at discovering and comparing mechanisms of cancer-causing and normal cell growth; and
- fostering coordination and collaboration that facilitates clinical translation of novel research findings into new therapeutic, diagnostic, or preventive trials.
Activities and programs at the UFHCC are acutely focused on the development of early-stage translational research aimed at the rapid advancement of scientific discoveries to clinical trials and resulting in improved patient care. The research and clinical facilities of the UFHCC represent a statewide resource that is sensitive to meeting the needs of Floridians. The Center’s research and patient-care collaborations also have links to other institutions, including Orlando Health, University of Miami/Sylvester Cancer Center, and H. Lee Moffitt Cancer Center.
Over the past decade, UF has made unprecedented institutional investments in cancer research and clinical care that have resulted in significant progress in cancer discovery, education, and patient outcomes. Evidence of the institution’s commitment to build on its state-of-the-art cancer programs includes construction of the $84.5-million Cancer and Genetics Research Complex (CGRC), which was completed in July 2006. The CGRC added 284,000 square feet of basic and translational research space and high-tech laboratory space and research equipment. Dedicated to discoveries in cancer and genetics, the CGRC is shared by multidisciplinary teams of investigators conducting scientific discovery under a collaborative model. UF has also made major investments in collaborations to foster cancer research and patient care for Florida’s residents. Current active cancer research awards by UFHCC members exceed $30 million.
The cancer research building houses laboratories for approximately 30 PIs and is equipped with workbenches, shelves, sinks, centrifuges, refrigerators, -20º C and -80º C freezers, tissue-culture hoods, tissue-culture incubators, water baths, light microscopes, power supplies, electrophoresis apparatuses, PCR machines, real-time PCR machines, and flow cytometers. Laboratories provide technical expertise and advice in the areas of FACS analysis, protein sequencing, peptide synthesis, oligonucleotide synthesis, proteomics, mass spectroscopy, transgenic mouse production, and gene expression. Each floor in these facilities has an autoclave, dark-room, library, small and large conference rooms, and walk-in cold and warm rooms. The core molecular laboratory for the Interdisciplinary Center for Biotechnology Research (ICBR) is in the research building and is available to all UFHCC members. The ICBR houses 12 partially subsidized facilities, including computing and bioinformatics, DNA sequencing, electron and confocal microscopy, flow cytometry, hybridoma production, protein chemistry, proteomics, mass spectrometry, microarray, and bioinformatics labs.
The building also includes a vivarium on the 5th floor and has all the facilities necessary for animal care, procedures, and irradiation. The UFHCC Research Laboratories and the ICBR are accredited by the American Association for the Accreditation of Laboratory Animal Care.
Three cesium-137 irradiators are available for total body or local irradiation of mice – one located in the animal vivarium on the 5th floor of the CGRC and two located in the main animal facility located in Biomedical Sciences Building. The animal facility in the Biomedical Sciences Building also has a XRAD 320 X-ray source for small animal irradiation. There is also a Varian Clinac 6/100C, located in Radiosurgery Biology Lab (RSB) in the McKnight Brain Institute, which is dedicated for use with animal models (non-human use) and image-guided stereotactic radiosurgery procedures.
The UF Health Cancer Center Biostatistics Core provides support for cancer researchers in the areas of biostatistics, epidemiology, health outcomes, healthcare economics, clinical trials, data analysis, and data management.
The UF Health Cancer Center Clinical Trials Office (CTO) supports principle investigators, maintains overall responsibility for the performance of clinical trials conducted by UFHCC investigators, and provides coordination and administrative support for the Center’s scientific review process and Data and Safety Monitoring Board.