Mechanisms of Oncogenesis Program Co-Leaders

Lizi Wu

Lizi Wu

Professor
Department: Molecular Genetics & Microbiology
Mailing Address:
CGRC Room 362
2033 Mowry Road
Gainesville FL 32610
Physical Address:
PO BOX 103610
Cancer & Genetics Research Complex
2033 MOWRY ROAD
GAINESVILLE FL 326110001

We study cancer cell signaling with expertise in signal transduction, genetic and epigenetic regulation, and animal models. Our current research is centered on two families of transcriptional co-activators, MAML and CRTC, which are essential components of Notch receptor signaling and LKB1-CRTC/CREB signaling pathways, respectively. We are investigating the molecular regulation and the roles of deregulated cell signaling in cancer generation and progression, with the goal of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets. We have 3 main projects: identification and functional characterization of a family of MAML transcriptional co-activators; identification, functional characterization, and targeting of CRTC1-MAML2 fusion oncogene; and investigations into deregulated LKB1-CRTC signaling in human cancers. Each project is expected to enhance our understanding of the roles and mechanisms of signaling in cancers, and such knowledge will help with diagnosis and treatment of tumors.

Publications:
Grants:
  • Jan 2024 ACTIVE
    The molecular basis of 7SK RNA methylation in non-small cell lung cancer
    NATL INST OF HLTH NCI · Co-Investigator
  • Jun 2023 ACTIVE
    UF Health Cancer Center Support Grant
    NATL INST OF HLTH NCI · Other
  • May 2023 ACTIVE
    Elucidating and targeting INSL4 signaling in lung cancer
    FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE · Principal Investigator
  • Sep 2022 ACTIVE
    UF HEALTH CANCER CENTER PILOT PROJECTS GRANTS FUNDED THROUGHTHE FLORIDA CONSORTIUM OF NATIONAL CANCER INSTITUTE CENTER
    UF HEALTH SHANDS HOSPITAL · Project Manager
  • Aug 2022 ACTIVE
    Embedded Printing of Human Respiratory Model with Air-Liquid Interface for COVID-19 Research
    NATL INST OF HLTH NHLBI · Co-Investigator
  • Apr 2021 ACTIVE
    Team-based Interdisciplinary Cancer Research Training Program
    NATL INST OF HLTH NCI · Co-Investigator
  • Aug 2020 ACTIVE
    Signaling and Targeting of CRTC1-MAML2 Fusion Oncoprotein in Salivary Gland
    NATL INST OF HLTH NIDCR · Principal Investigator
  • Feb 2019 ACTIVE
    Aberrant CRTC activation as a unique vulnerability of lung cancer with LKB1 inactivation
    NATL INST OF HLTH NCI · Principal Investigator
  • Sep 2018 – Aug 2021
    OR-DRPD-ROF2018: Identification of the first extracellular nicotinamide adenine dinucleotide-binding receptor in animal cells
    UF RESEARCH · Co-Investigator
  • Apr 2015 – Mar 2018
    A novel noncoding RNA and human lung cancers with inactivated LKB1 signaling
    NATL INST OF HLTH NCI · Principal Investigator
  • Jan 2015 ACTIVE
    UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
    UF HEALTH SHANDS HOSPITAL · Project Manager
  • Aug 2014 – May 2020
    Signaling and targeting of CRTC1-MAML2 fusion oncoprotein in salivary gland tumor
    NATL INST OF HLTH · Principal Investigator
  • Feb 2012 – Mar 2018
    Sponholtz Family Cancer Research Fund – #F14006
    UF FOUNDATION · Project Manager
  • Mar 2006 – May 2023
    Davis Cancer Researach Equipment
    UF FOUNDATION · Project Manager
Patents:
  • Issued September 2019
    LncRNA Serves as a Biomarker and Therapeutic Target
    #10,415,095
Zhijian Qian

Zhijian Qian Ph.D.

Professor, Pierre Chagnon Professor Of Cancer Research
Department: MD-HEMATOLOGY/ONCOLOGY
Mailing Address:
PO Box 100278
GAINESVILLE FL 32610
Physical Address:
2033 MOWRY RD
GAINESVILLE FL 32611

Zhijian Qian Ph.D. joined Department of Medicine, at the University of Florida in April, 2018. Currently, he is a tenured full Professor. Before that, he had been serving as a tenured Associate Professor of medicine at the University of Illinois at Chicago for several years.

Dr. Qian received his Ph.D. degree from Shanghai Institute of Cell Biology, Chinese Academy of Science, China, and then conducted postdoc training at the University of Illinois at Chicago and the University of Chicago. He established his independent research laboratory in 2010 in the department of Medicine at University of Illinois at Chicago.

Dr. Qian is a scholar of The Leukemia & Lymphoma Society (2018) and Research of the year. His research has been supported by multiple RO1 grants from NIH and other private foundations.

Current Research Interests: The long-term goal of Qian laboratory is to understand the mechanisms that underlie the development of blood cancer with a focus on studying the genetic pathways that control the proliferation, survival and self-renewal of normal or leukemic hematopoietic stem cells, and to identify novel therapeutic strategies for treatment of myeloid malignant diseases. Current my lab research interests include 1) understanding molecular regulation of normal hematopoietic stem cell (HSC) and its leukemic transformation, 2) determining the role and mechanisms of the Wnt/β-catenin signaling in the development and maintenance of myeloid neoplasms, 3) understanding transcriptional, epigenetic and epitranscriptome regulation of normal hematopoiesis and leukemogenesis, 4) studying post-translational modifications of RNA m6A methylation regulators in cancer, and 5) developing novel targeted therapies for myeloid malignant diseases and solid tumors including lung and head-neck cancers.

Publications:
Grants:
  • Jun 2023 ACTIVE
    UF Health Cancer Center Support Grant
    NATL INST OF HLTH NCI · Other
  • Sep 2022 ACTIVE
    The role of ALKBH5-mediated RNA demethylation in the maintenance of genomic stability in HSPCs
    NATL INST OF HLTH NIDDK · Principal Investigator
  • May 2022 ACTIVE
    The Novel Role and Mechanism of RBM33 in Leukemogenesis
    NATL INST OF HLTH NCI · Principal Investigator
  • May 2022 ACTIVE
    The role of YTHDC1 in normal and malignant hematopoiesis
    NATL INST OF HLTH NCI · Principal Investigator
  • Jan 2022 ACTIVE
    Role of the TET1 short isoform in MDS development and maintenance
    NATL INST OF HLTH NHLBI · Principal Investigator
  • Nov 2021 – Mar 2024
    Mondello Startup Funds for Zhijian Qian
    UF FOUNDATION · Co-Project Director/Principal Investigator
  • Nov 2021 – Mar 2024
    Mondello and Davis Startup Funds for Zhijian Qian
    UF FOUNDATION · Co-Project Director/Principal Investigator
  • Sep 2021 – Aug 2022
    The role of ALKBH5-mediated RNA demethylation in the maintenance of genomic stability in HSPCs
    NATL INST OF HLTH NIDDK · Principal Investigator
  • Jun 2021 – Oct 2021
    FOXM1 as a therapeutic target for MLL-rearranged AMLs
    FL DEPT OF HLTH LIVE LIKE BELLA · Principal Investigator
  • Jun 2021 – Apr 2024
    The Role of ALKBH5 in Leukemogenesis
    FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE · Principal Investigator
  • Jun 2019 – May 2021
    The molecular mechanism of clonal dominance in 5q(del) MDS
    NATL INST OF HLTH NIDDK · Principal Investigator
  • Apr 2019 – Mar 2022
    Molecular Basis and Treatment of Pediatric AML with Hyperexpression of EVI1
    FL DEPT OF HLTH LIVE LIKE BELLA · Principal Investigator
  • Dec 2018 – Mar 2021
    The role of EVI1-induced DNA hypermethylation in Leukemogenesis
    NATL INST OF HLTH NHLBI · Principal Investigator
  • Jul 2018 – Jun 2023
    The Role of FOXM1 downregulation in the development of clonal dominance in del(5q) MDS
    LEUKEMIA & LYMPHOMA SOC · Principal Investigator
  • Nov 2017 – Oct 2022
    The Harry T. Mangurian, Jr. Foundation – Support for the Study of Therapy Resistant Leukemia
    UF FOUNDATION · Project Manager