Structure-Based Drug Design Core Lab

What is the mission of the Structure-Based Drug Design Core Lab?

To facilitate drug development by combining structure-based methods with strengths of University of Florida researchers with applied goals.

What services does the Structure-Based Drug Design Core Lab provide?

*Please click on the links below for more detailed information about those services.

Drug development resources available for the following:

What are the costs associated with these services?

X-Ray Crystallography

 $500 Crystallization trials

 $2000 X-ray data collection and structure determination

Molecular docking

 $1000 per site

Lead Optimization

 $1000 per site

Does the Structure-Based Drug Design Core Lab have any new services it anticipates adding soon?

Yes, we are offering structure-based screening services to researchers using multiple chemical libraries.

  1. UF College of Pharmacy library consisting of 145 new chemical entities
  2. 1,217 FDA approved drugs
  3. 139,735 National Cancer Institute developmental therapeutics program small molecule library

How should you contact the Structure-Based Drug Design Core Lab to engage its services in a project or ask advice?

Please contact the Structure-Based Drug Design Core Lab and e-mail Dr. David Ostrov to request advice and services. If possible, provide information on:

  1. Project goal
  2. Name of the molecular target protein (sequence if possible)
  3. Description of assay to measure functional activities

Dr. Ostrov’s email is ostroda@pathology.ufl.edu and his number is (352) 273-8166.

This core is available to individuals who are Cancer Center members. In order to become a member of the UF Health Cancer Center (UFHCC), please visit the Membership Policy and Application site.  For further questions about membership with the UFHCC, please contact ResearchAdmin@cancer.ufl.edu.

How can you provide feedback on the Structure-Based Drug Design Core Lab?

The UFHCC is interested to learn how this service did or did not meet your needs, and whether you have any suggestions for improvement.  To provide feedback about the Structure-Based Drug Design Core Lab, please send all comments to ResearchAdmin@cancer.ufl.edu.