Mechanisms of Oncogenesis

MOO program mtg

The mission of the University of Florida Health Cancer Center (UFHCC) Mechanisms of Oncogenesis (MOO) program is to increase the understanding of how normal cells undergo multiple complex changes leading to transformation into cancer cells. The research aims focus on genomic and epigenetic mutations and cell signaling, the role of noncoding RNAs in cancer, and on how DNA tumorviruses dysregulate host cellular pathways leading to cancer.

The scientific objectives of the MOO program are to identify and understand cellular pathways that are dysregulated during neoplastic transformation and progression to decipher how these changes promote the cancer phenotype, and to develop methodologies to target these cancer-specific signaling events.

Aims

The long-term goal of these aims is to develop rational bases for combining interventions using these targets in a patient-specific, precision medicine manner, and to translate them into novel therapeutic approaches.

Program Co-leaders

Learn more about Drs. Rolf Renne and Daohong Zhou.

Working Groups

Learn more about MOO’s working groups.

Program Members

To request an update, please email ResearchAdmin@cancer.ufl.edu.

NameDegree(s)Research ProgramTitleDepartmentCollegeResearch Interest Topics
Liao, Daiqing

Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy & Cell BiologyMedicineApoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Chemotherapy; Drug Design; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genital-Urinary/Prostate; Immunoregulation & Suppression; Tumor Virology/Virus-Host Interactions
Ishov, Alexander

Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy & Cell BiologyMedicineBreast; Prostate; Cancer Genetics; Chemotherapy; Epigenetics & Cancer
Qiu, Yi

Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorAnatomy & Cell BiologyMedicineEpigenetics & Cancer; Cell Signaling Pathways; Hematologic Malignancies/Blood & Marrow Transplant
Opavsky, Rene

Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy & Cell BiologyMedicineEpigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Huang, Shuang

Ph.DMechanisms of Oncogenesis (MOO)ProfessorAnatomy & Cell BiologyMedicineBreast; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Gene Regulation; Gynecological; Metastasis; MicroRNAs; RNA Processing
Xiao, Rui

Xiao
Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorAging & Geriatric ResearchMedicineTranscription Factors; Aging; Cellular Stress Response; Sensory Modulation of Aging; Environmental Factors
Lu, Jianrong

Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorBiochemistry & Molecular BiologyMedicineAngiogenesis; Apoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Metastasis; Post-Transcriptional Gene Regulation
Bungert, Jorg

Ph.DMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & Molecular BiologyMedicineEpigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Brown, Kevin

Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorBiochemistry & Molecular BiologyMedicineDNA Damage
Agbandje-McKenna, Mavis

Ph.DMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & Molecular BiologyMedicineGene Therapy; Oncolytic Viral Vectors; Structural Virology; Targeted Cancer Therapy
Kilberg, Michael

Ph.DMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & Molecular BiologyMedicineCell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Leukemia; Liver; Post-Transcriptional Gene Regulation
Kladde, Michael

Ph.DMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & Molecular BiologyMedicineCancer Epigenetics; Colorectal and Breast Cancer; Glioblastoma; Cell Signaling Pathways
Xie, Mingyi

Xie
Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorBiochemistry & Molecular BiologyMedicineBioinformatics; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; MicroRNAs; RNA Processing; Tumor Virology/Virus-Host Interactions
Frost, Susan

Ph.DMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & Molecular BiologyMedicineBreast; Chemotherapy; Environment
Yang, Thomas

Ph.DMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & Molecular BiologyMedicineEpigenetics
Bacher, Rhonda

Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorBiostatisticsPublic Health and Health ProfessionsBioinformatics; Biostatistics
Datta, Susmita

Ph.DMechanisms of Oncogenesis (MOO)ProfessorBiostatisticsPublic Health & Health ProfessionsBioinformatics; RNA processing
Toth, Zsolt

Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorOral BiologyDentistryCancer Genetics; Epigenetics & Gene Regulation; Immunoregulation & Suppression; Infection Control; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions
Concannon, Patrick

Ph.DMechanisms of Oncogenesis (MOO)ProfessorPathology, Immunology & Laboratory MedicineMedicineMedicine; Breast; Diabetes
Licht, Jonathan

M.D.Mechanisms of Oncogenesis (MOO)ProfessorHematology & OncologyMedicineDNA Damage & Repair; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Wang, Gary

Ph.D, M.D.Mechanisms of Oncogenesis (MOO)Associate ProfessorInfectious DiseaseMedicineBioinformatics; Gene Therapy; Liver
Bennett, Richard

Ph.DMechanisms of Oncogenesis (MOO)Research Assistant ProfessorHematology & OncologyMedicineApoptosis & Cell Death Pathways; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Leukemia; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions
Bloom, David

Ph.DMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyMedicineEpigenetics & Cancer; Oncolytic Viral Vectors; Tumor Virology/Virus-Host Interactions
Renne, Rolf

Ph.DMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyMedicineNoncoding RNAs, Cell Signaling Pathways; Lymphoma; Skin/Melanoma; Tumor Virology/Virus-Host Interactions
Tibbetts, Scott

Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorMolecular Genetics & MicrobiologyMedicineVirology/Virus-Host Interactions; Noncoding RNAs; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Infection Control; Leukemia; Lymphoma; MicroRNAs; Stem Cell; Tumor
Wu, Lizi

Wu
Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorMolecular Genetics & MicrobiologyMedicineApoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Noncoding RNAs; Drug Design; Epigenetics & Cancer; Gynecological; Leukemia; Tumor Virology/Virus-Host Interactions
Zhou, Lei

Zhou
Ph.D, BMedMechanisms of Oncogenesis (MOO)Associate ProfessorMolecular Genetics & MicrobiologyMedicineApoptosis & Cell Death Pathways; Bioinformatics; Cancer Genetics; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Radiation Oncology; Senescence; Genetic Cancer animal models
Conesa Cegarra, Ana

Ph.DMechanisms of Oncogenesis (MOO)ProfessorMicrobiology & Cell ScienceIFASGenetic determinants; Bioinformatics
De Crecy Lagard, Valerie

Ph.DMechanisms of Oncogenesis (MOO)ProfessorMicrobiology & Cell ScienceIFASCell Signaling Pathways
Maupin-Furlow, Julie

Ph.DMechanisms of Oncogenesis (MOO)ProfessorMicrobiology & Cell ScienceIFASMicrobiology; Cell Signaling Pathways
Guryanova, Olga

Guryanova

M.D, Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorPharmacology & TherapeuticsMedicineCancer Genetics; Cancer Susceptibility; Cell Signaling Pathways; DNA Damage & Repair; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Stem Cell
Li, Chenglong

Ph.DMechanisms of Oncogenesis (MOO)ProfessorMedicinal ChemistryPharmacyCell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Neuro-Oncology; Pediatric Oncology; Stem Cell; Targeted Cancer Therapy
Srivastava, Arun

Ph.D, BSc, MSc Mechanisms of Oncogenesis (MOO)ProfessorPediatric ResearchMedicineGene Therapy; AAV Biology; Liver; Stem Cell; Targeted Cancer Therapy; Tumor Virology/Virus-Host Interactions
Ling, Chen

Ph.DMechanisms of Oncogenesis (MOO)Research Assistant ProfessorPediatric ResearchMedicineGene Therapy; AAV biology; Hepatocellular carcinoma
Zolotukhin, Sergei

Ph.DMechanisms of Oncogenesis (MOO)ProfessorPediatric ResearchMedicineAAV Biology, Cancer Gene Therapy
Terada, Naohiro

Ph.D, M.D.Mechanisms of Oncogenesis (MOO)ProfessorPathologyMedicineAngiogenesis; Cell Signaling Pathways; Stem Cell
Jiang, Qiu-Xing

Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorMicrobiology & Cell ScienceAgriculture & Life SciencesEndocrine; Neuroendocrine Cancers; Cancer Genetics; MicroRNAs; Nanotechnology; Structural Biology
Tang, Xin

Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorMechanical & Aerospace EngineeringEngineeringAngiogenesis; Breast; Epigenetics & Cancer; Immunoregulation & Suppression; Immunotherapy; Integrative Medicine; Metastasis; Nanotechnology; Noninvasive Imaging/Tomography; Vascular Targeting
Jin, Lingtao

jin
Ph.D.Mechanisms of Oncogenesis (MOO)Assistant ProfessorAnatomy & Cell BiologyMedicineDrug Resistance; Metastasis; Nutrition; Dietary Supplements & Cancer
Makki, Nadja

makki
Ph.D.Mechanisms of Oncogenesis (MOO)Assistant ProfessorAnatomy & Cell BiologyMedicineEpigenetics & Gene Regulation
Caglayan, Melike

Caglayan

Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorBiochemistry & Molecular BiologyMedicineChemotherapy; DNA Damage & Repair; DNA Replication; Drug Design
Papp, Bernadett

Ph.DMechanisms of Oncogenesis (MOO)Research Assistant ProfessorOral BiologyDentistryBioinformatics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Stem Cell; Tumor Virology/Virus-Host interactions
Qian, Zhijian

Qian
Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorMedicine - Hematology & OncologyMedicineCancer Genetics; Cell Signaling Pathways; Drug Resistance; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Stem Cell
Michailidis, George

Ph.DMechanisms of Oncogenesis (MOO)ProfessorInformatics InstitutePublic Health & Health ProfessionsBioinformatics and Biostatistics
Zhang, Weizhou

Ph.DMechanisms of Oncogenesis (MOO)ProfessorPathology, Immunology & Laboratory MedicineMedicineAngiogenesis; Breast; Immunoregulation & Suppression; Tumor Immunology and Immunotherapy
Baer, Charles

Ph.DMechanisms of Oncogenesis (MOO)Assistant ProfessorBiologyLiberal Arts & SciencesEvolutionary Biology; Population Genetics; Quantitative Genetics
Rong, Libin

Ph.DMechanisms of Oncogenesis (MOO)Associate ProfessorMathematicsLiberal Arts & SciencesEpidemiology
Zhou, Daohong


Ph.D.Mechanisms of Oncogenesis (MOO)ProfessorPharmacodynamicsPharmacyDrug Design; Cell Signaling Pathways
Bhaduri-McIntosh, Sumita


Ph.D, M.D.Mechanisms of Oncogenesis (MOO)Associate ProfessorPediatrcs-Infectious DiseasesMedicineCancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Tumor Virology/Virus-Host Interactions
Fredenburg, Kristianna


Ph.D, M.D.Mechanisms of Oncogenesis (MOO)Assistant ProfessorPathologyMedicineHead & Neck; microRNAs; cancer disparities
Murfee, Walter

Ph.D.Mechanisms of Oncogenesis (MOO)Associate ProfessorBiomedical EngineeringEngineeringAngiogenesis; Stem Cell; Targeted Cancer Therapy; Vascular Targeting
Lele, Tanmay

Ph.D.Mechanisms of Oncogenesis (MOO)Associate ProfessorChemical EngineeringEngineeringAngiogenesis; Breast; Epigenetics & Cancer; Epigenetics & Gene Regulation; MicroRNAs; Nanotechnology; RNA Processing
Perez, Alberto

perez
Ph.D.Mechanisms of Oncogenesis (MOO)Assistant ProfessorChemistryLiberal Arts & SciencesBioinformatics; Epigenetics & Gene Regulation
Kahveci, Tamer


Ph.D.Mechanisms of Oncogenesis (MOO)ProfessorComputer & Information Science & EngineeringEngineeringBioinformatics
Kaye, Frederic

Ph.DMechanisms of Oncogenesis (MOO) & Cancer Therapeutics & Host Response (CTHR)ProfessorHematology & OncologyMedicineCancer Genetics; Cell Signaling Pathways; Genetic Determinants of Cancer; Head & Neck; Lung; Thoracic Oncology; Oncolytic Viral Vectors
Daaka, Yehia

daaka
Ph.D.Mechanisms of Oncogenesis (MOO)ProfessorAnatomy & Cell BiologyMedicineAndrogen receptors; Human pathophysiology receptors