Mechanisms of Oncogenesis

Dr. Renne speaks at the MOO program meeting

The mission of the Mechanisms of Oncogenesis (MOO) program at the University of Florida Health Cancer Center (UFHCC) is to understand how normal cells undergo complex changes leading to cancer. The scientific objectives of the MOO program are to elucidate the deregulated genetic and epigenetic events that drive tumor initiation and progression and develop new cancer targeting strategies.  The research aims focus on identifying and characterizing genetic and epigenetic alterations, elucidating the role of noncoding RNAs in cancer, studying oncogenic mechanisms of DNA tumor viruses, and translating MOO discovery to novel therapeutic approaches.

Aims

The long-term goal of these aims is to develop rational bases for combining interventions using these targets in a patient-specific, precision medicine manner, and to translate them into novel therapeutic approaches.

Program Co-leaders

Learn more about Drs. Lizi Wu and Daohong Zhou.

Program Members

To request an update, please email ResearchAdmin@cancer.ufl.edu.

NamemyNCBI LinkResearch ProgramTitleDepartmentLab PageCollegeResearch Interest Topics
Zajac-Maria Kaye, PhD

myNCBICancer Therapeutics & Host Response (CTHR); Mechanisms of Oncogenesis (MOO)ProfessorAnatomy & Cell BiologyMedicineAngiogenesis; Apoptosis & Cell Death Pathways; Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Drug Design; Endocrine; Epigenetics & Cancer; Epigenetics & Gene Regulation; Gene Therapy
Piyush Jain, PhD

Jain
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorChemical EngineeringLabEngineeringCancer Genetics; DNA Damage & Repair; DNA Recombination; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Gene Therapy; Nanotechnology; Noninvasive Imaging/Tomography; RNA Processing; Targeted Cancer Therapy
Jia Chang, DDS

chang

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorPeriodontologyDentistryBone & Soft Tissue (Sarcoma); Bioinformatics; Post-Transcriptional Gene Regulation; Stem Cell; Biostatistics; Angiogenesis
Ryan Kolb, PhD
kolb
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorPathology, Immunology & Laboratory MedicineMedicineTargeted Cancer Therapy; Vascular Targeting; Breast; Angiogenesis; Drug Resistance; Immunoregulation & Suppression; Immunotherapy; Kidney
Jason Brant, PhD

brant
Mechanisms of Oncogenesis (MOO)Research Assistant ProfessorBiostatisticsPublic Health & Health ProfessionsBioinformatics; Epigenetics & Cancer; Epigenetics & Gene Regulation
Kethandapatti Balaji, MD

balaji

Mechanisms of Oncogenesis (MOO)ProfessorUrologyMedicineGenital-Urinary/Prostate; Kidney; Nanotechnology; Surgical Oncology
Zsolt Toth, PhD

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorOral BiologyLabDentistryCancer Genetics; Epigenetics & Gene Regulation; Immunoregulation & Suppression; Infection Control; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions
Bernadett Papp, PhD

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorOral BiologyLabDentistryBioinformatics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Stem Cell; Tumor Virology/Virus-Host interactions
Xin Tang, PhD

Mechanisms of Oncogenesis (MOO)Assistant ProfessorMechanical & Aerospace EngineeringEngineeringAngiogenesis; Breast; Epigenetics & Cancer; Immunoregulation & Suppression; Immunotherapy; Integrative Medicine; Metastasis; Nanotechnology; Noninvasive Imaging/Tomography; Vascular Targeting
Walter Murfee, PhD

Mechanisms of Oncogenesis (MOO)Associate ProfessorBiomedical EngineeringLabEngineeringAngiogenesis; Stem Cell; Targeted Cancer Therapy; Vascular Targeting
Tamer Kahveci, PhD


Mechanisms of Oncogenesis (MOO)ProfessorComputer & Information Science & EngineeringLabEngineeringBioinformatics
Valerie De Crecy Lagard, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMicrobiology & Cell ScienceAgricultural & Life SciencesCell Signaling Pathways
Julie Maupin, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMicrobiology & Cell ScienceAgricultural & Life SciencesMicrobiology; Cell Signaling Pathways
Charles Baer, PhD

Mechanisms of Oncogenesis (MOO)ProfessorBiologyLabLiberal Arts & SciencesEvolutionary Biology; Population Genetics; Quantitative Genetics
Libin Rong, PhD

Mechanisms of Oncogenesis (MOO)Associate ProfessorMathematicsLiberal Arts & SciencesEpidemiology
Alberto Perez, PhD

perez
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorChemistryLabLiberal Arts & SciencesBioinformatics; Epigenetics & Gene Regulation
Margaret (Peggy) Wallace, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyLabMedicineBone & Soft Tissue Sarcomas; Breast; Cancer Genetics; DNA Damage & Repair; Epigenetics & Cancer; Genetic Determinants of Cancer; Head & Neck; Hematologic Malignancies/Blood & Marrow Transplant; Skin/Melanoma; Vascular Targeting
Daiqing Liao, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy & Cell BiologyMedicineApoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Chemotherapy; Drug Design; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genital-Urinary/Prostate; Immunoregulation & Suppression; Tumor Virology/Virus-Host Interactions
Alexander Ishov, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy & Cell BiologyMedicineBreast; Prostate; Cancer Genetics; Chemotherapy; Epigenetics & Cancer
Rene Opavsky, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy & Cell BiologyMedicineEpigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Shuang Huang, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorAnatomy & Cell BiologyMedicineBreast; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Gene Regulation; Gynecological; Metastasis; MicroRNAs; RNA Processing
Rui Xiao, PhD

Xiao
myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorAging & Geriatric ResearchMedicineTranscription Factors; Aging; Cellular Stress Response; Sensory Modulation of Aging; Environmental Factors
Jianrong Lu, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorBiochemistry & Molecular BiologyMedicineAngiogenesis; Apoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Metastasis; Post-Transcriptional Gene Regulation
Jorg Bungert, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & Molecular BiologyLabMedicineEpigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Michael Kladde, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & Molecular BiologyLabMedicineCancer Epigenetics; Colorectal & Breast Cancer; Glioblastoma; Cell Signaling Pathways
Mingyi Xie, PhD

Xie

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorBiochemistry & Molecular BiologyLabMedicineBioinformatics; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; MicroRNAs; RNA Processing; Tumor Virology/Virus-Host Interactions
Patrick Concannon, PhD

Mechanisms of Oncogenesis (MOO)ProfessorPathology, Immunology & Laboratory MedicineLabMedicineMedicine; Breast; Diabetes
Jonathan Licht, MD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMedicine- Hematology & OncologyLabMedicineDNA Damage & Repair; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Gary Wang, MD, PhD

Mechanisms of Oncogenesis (MOO)ProfessorMedicine-Infectious Disease & Global MedicineMedicineBioinformatics; Gene Therapy; Liver
Richard Bennett, PhD

Mechanisms of Oncogenesis (MOO)Research Assistant ProfessorMedicine-Hematology & OncologyMedicineApoptosis & Cell Death Pathways; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Leukemia; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions
David Bloom, PhD

Mechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyMedicineEpigenetics & Cancer; Oncolytic Viral Vectors; Tumor Virology/Virus-Host Interactions
Rolf Renne, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyLabMedicineNoncoding RNAs; Cell Signaling Pathways; Lymphoma; Skin/Melanoma; Tumor Virology/Virus-Host Interactions
Scott Tibbetts, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyLabMedicineVirology/Virus-Host Interactions; Noncoding RNAs; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Infection Control; Leukemia; Lymphoma; MicroRNAs; Stem Cell; Tumor
Lizi Wu, PhD

Wu
myNCBIMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyMedicineApoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Noncoding RNAs; Drug Design; Epigenetics & Cancer; Gynecological; Leukemia; Tumor Virology/Virus-Host Interactions
Lei Zhou, PhD, BMed

Zhou
Mechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyMedicineApoptosis & Cell Death Pathways; Bioinformatics; Cancer Genetics; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Radiation Oncology; Senescence; Genetic Cancer animal models
Olga Guryanova, MD, PhD

Guryanova

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorPharmacology & TherapeuticsMedicineCancer Genetics; Cancer Susceptibility; Cell Signaling Pathways; DNA Damage & Repair; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Stem Cell
Arun Srivastava, PhD, BSc, MSc

myNCBIMechanisms of Oncogenesis (MOO)ProfessorPediatricsLabMedicineGene Therapy; AAV Biology; Liver; Stem Cell; Targeted Cancer Therapy; Tumor Virology/Virus-Host Interactions
Sergei Zolotukhin, PhD

Mechanisms of Oncogenesis (MOO)ProfessorPediatricsLabMedicineAAV Biology; Cancer Gene Therapy
Lingtao Jin, PhD

jin
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorAnatomy & Cell BiologyMedicineDrug Resistance; Metastasis; Nutrition; Dietary Supplements & Cancer
Nadja Makki, PhD

makki
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorAnatomy & Cell BiologyLabMedicineEpigenetics & Gene Regulation
Melike Caglayan, PhD

Caglayan

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorBiochemistry & Molecular BiologyLabMedicineChemotherapy; DNA Damage & Repair; DNA Replication; Drug Design
Zhijian Qian, PhD

Qian
Mechanisms of Oncogenesis (MOO)ProfessorMedicine- Hematology & OncologyMedicineCancer Genetics; Cell Signaling Pathways; Drug Resistance; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Stem Cell
Weizhou Zhang, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorPathology, Immunology & Laboratory MedicineMedicineAngiogenesis; Breast; Immunoregulation & Suppression; Tumor Immunology & Immunotherapy
Sumita Bhaduri-McIntosh, MD, PhD



Mechanisms of Oncogenesis (MOO)Chief & Associate ProfessorPediatrics- Infectious DiseasesMedicineCancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Tumor Virology/Virus-Host Interactions
Kristianna Fredenburg, MD, PhD


Mechanisms of Oncogenesis (MOO)Assistant ProfessorPathology, Immunology & Laboratory MedicineMedicineHead & Neck; microRNAs; cancer disparities
Yehia Daaka, PhD

daaka
myNCBIMechanisms of Oncogenesis (MOO)ProfessorAnatomy & Cell BiologyMedicineAndrogen receptors; Human pathophysiology receptors
Thomas Schmittgen, PhD

Schmittgen
Mechanisms of Oncogenesis (MOO)Chair & ProfessorPharmaceuticsLabPharmacyCancer Genetics; Drug Design; Gastro-Intestinal; Head & Neck; Health Disparities; Liver; MicroRNAs; Nanotechnology
Chenglong Li, PhD

Mechanisms of Oncogenesis (MOO)ProfessorMedicinal ChemistryPharmacyCell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Neuro-Oncology; Pediatric Oncology; Stem Cell; Targeted Cancer Therapy
Daohong Zhou, PhD


Mechanisms of Oncogenesis (MOO)ProfessorPharmacodynamicsPharmacyDrug Design; Cell Signaling Pathways
Susmita Datta, PhD, MBA, MS

Mechanisms of Oncogenesis (MOO)ProfessorBiostatisticsPublic Health & Health ProfessionsBioinformatics; RNA processing
George Michailidis, PhD

Mechanisms of Oncogenesis (MOO)ProfessorInformatics InstitutePublic Health & Health ProfessionsBioinformatics & Biostatistics
Rhonda Bacher, PhD

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorBiostatisticsPublic Health & Health ProfessionsBioinformatics; Biostatistics
Juan Guan, PhD

guan

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorPhysicsLiberal Arts & SciencesCancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Drug Design; Nanotechnology
Matthew Eddy, PhD
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorChemistryLiberal Arts & Sciences
Zhe Ma, PhD
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorMolecular Genetics & MicrobiologyLabMedicine
Robert McKenna, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorBiochemistry & molecular BiologyLabMedicineTargeted Cancer Therapy; Gene Therapy; Oncolytic Viral Vectors
Frederic Kaye, PhD

Cancer Therapeutics & Host Response (CTHR); Mechanisms of Oncogenesis (MOO)ProfessorMedicine- Hematology & OncologyMedicineCancer Genetics; Cell Signaling Pathways; Genetic Determinants of Cancer; Head & Neck; Lung; Thoracic Oncology; Oncolytic Viral Vectors
Meghan Ferrall-Faribanks, PhD

ferral-fairbanks
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorBiomedical EngineeringEngineeringBreast; Drug Resistance; Gynecological; Health Disparities; Hematologic Malignancies/Blood & Marrow Transplant; Kidney; Leukemia; Metastasis
Sara Falzarano, MD, PhD

Falzarano

Mechanisms of Oncogenesis (MOO)Clinical Associate ProfessorPathology & Laboratory MedicineMedicineCancer Genetics; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Genital-Urinary/Prostate; Kidney
Kiley Graim, PhD

Graim

Mechanisms of Oncogenesis (MOO)Assistant ProfessorComputer and Information Science and EngineeringEngineeringBioinformatics; Genetic Determinants of Cancer
Lauren McIntyre, PhD

McIntyre
Mechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics & MicrobiologyMedicineBioinformatics; Biostatistics; Cancer Genetics; Epigenetics & Gene Regulation; Nanotechnology; RNA Processing; Structural Virology