The mission of the Mechanisms of Oncogenesis (MOO) program at the University of Florida Health Cancer Center is to understand how normal cells undergo complex changes leading to cancer. The scientific objectives of the MOO program are to elucidate the deregulated genetic and epigenetic events that drive tumor initiation and progression and develop new cancer targeting strategies.
The research aims focus on identifying and characterizing genetic and epigenetic alterations, elucidating the role of noncoding RNAs in cancer, studying oncogenic mechanisms of DNA tumor viruses, and translating MOO discovery to novel therapeutic approaches.
Aims
The aims of the MOO program are to elucidate the role of genetic and epigenetic alterations in cancer; define the role of regulatory microRNAs and long noncoding RNAs in oncogenesis; and translate MOO discoveries into novel therapeutic approaches.
Program Co-leaders
Learn more about Lizi Wu, Ph.D., and Zhijian Qian, Ph.D.
Program Members
To request an update, please email ResearchDevelopment@cancer.ufl.edu.
| Name | myNCBI Link | Research Program | Title | Department | Lab Page | College | Research Interest Topics |
|---|---|---|---|---|---|---|---|
Alberto Perez, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Chemistry | Lab | Liberal Arts and Sciences | Bioinformatics; Epigenetics & Gene Regulation |
Alexander Ishov, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Anatomy and Cell Biology | Medicine | Breast; Prostate; Cancer Genetics; Chemotherapy; Epigenetics & Cancer | |
Arun Srivastava, PhD, BSc, MSc | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Pediatrics | Lab | Medicine | Gene Therapy; AAV Biology; Liver; Stem Cell; Targeted Cancer Therapy; Tumor Virology/Virus-Host Interactions |
Bernadett Papp, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Oral Biology | Lab | Dentistry | Bioinformatics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Stem Cell; Tumor Virology/Virus-Host interactions |
Bowen Yan, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Research Assistant Professor | Pharmacology and Therapeutics | Medicine | Hematologic Malignancies; Blood & Marrow Transplant | |
Charles Baer, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Biology | Lab | Liberal Arts and Sciences | Evolutionary Biology; Population Genetics; Quantitative Genetics | |
Chenglong Li, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Medicinal Chemistry | Pharmacy | Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Neuro-Oncology; Pediatric Oncology; Stem Cell; Targeted Cancer Therapy | ||
Christopher Vulpe, MD, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Physiological Sciences | Lab | Veterinary Medicine | Apoptosis & Cell Death Pathways; Breast; Cancer Genetics; Chemotherapy; DNA Damage & Repair; Drug Resistance; Environment; Leukemia; Pediatric Oncology; CRSPR; Synthetic Lethal Screens; Precision Medicine | |
Cleverson De Souza, DVM, MS, PhD, DACVP | Mechanisms of Oncogenesis (MOO) | Associate Professor | Comparative, Diagnostic, & Population Medicine | Veterinary Medicine | Immunoregulation & Suppression; Immunotherapy; Leukemia; Lymphoma; Nanotechnology | ||
Courtney Miller, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Scripps Biomedical Research | Medicine | Head & Neck; Neuro-Oncology |
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Daiqing Liao, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Anatomy and Cell Biology | Medicine | Apoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Chemotherapy; Drug Design; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genital-Urinary/Prostate; Immunoregulation & Suppression; Tumor Virology/Virus-Host Interactions | |
David Bloom, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Molecular Genetics and Microbiology | Medicine | Epigenetics & Cancer; Oncolytic Viral Vectors; Tumor Virology/Virus-Host Interactions | ||
Dietmar Siemann, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Radiation Oncology | Lab | Medicine | Breast; Cell Signaling Pathways; Chemotherapy; Drug Design; Environment; Genital-Urinary/Prostate; Metastasis; Radiation Oncology; Stem Cell; Targeted Cancer Therapy; Vascular Targeting | |
Gary Wang, MD, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Medicine | Medicine | Bioinformatics; Gene Therapy; Liver | ||
Jason Brant, PhD | Mechanisms of Oncogenesis (MOO) | Research Assistant Professor | Pathology, Immunology and Laboratory Medicine | Medicine | Bioinformatics; Epigenetics & Cancer; Epigenetics & Gene Regulation | ||
Jason Butler, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Medicine | Medicine | Angiogenesis; Cell Signaling Pathways; Chemotherapy; DNA Damage & Repair; Hematologic Malignancies/Blood & Marrow Transplant; Stem Cell; Vascular Targeting | ||
Jia Chang, DDS | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Periodontology | Dentistry | Bone & Soft Tissue (Sarcoma); Bioinformatics; Post-Transcriptional Gene Regulation; Stem Cell; Biostatistics; Angiogenesis | |
Jianrong Lu, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Biochemistry and Molecular Biology | Medicine | Angiogenesis; Apoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Metastasis; Post-Transcriptional Gene Regulation | |
Jonathan Licht, MD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Medicine | Lab | Medicine | DNA Damage & Repair; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma |
Jorg Bungert, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Biochemistry and Molecular Biology | Lab | Medicine | Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant |
Juan Guan, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Physics | Liberal Arts and Sciences | Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Drug Design; Nanotechnology | |
Julie Maupin, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Microbiology & Cell Science | Agricultural and Life Sciences | Microbiology; Cell Signaling Pathways | |
Kate Carroll, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Scripps Biomedical Research | Medicine | Cell Signaling Pathways; Drug Design | ||
Katrin Karbstein, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Integrative Structural and Computational Biology | Medicine | Molecular Chaperones; Post-Transcriptional Gene Regulation; RNA Processing | |
Kiley Graim, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Computer and Information Science and Engineering | Engineering | Bioinformatics; Genetic Determinants of Cancer |
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Kristianna Fredenburg, MD, PhD | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Pathology, Immunology and Laboratory Medicine | Medicine | Head & Neck; microRNAs; cancer disparities | ||
Lauren McIntyre, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Molecular Genetics and Microbiology | Medicine | Bioinformatics; Biostatistics; Cancer Genetics; Epigenetics & Gene Regulation; Nanotechnology; RNA Processing; Structural Virology | ||
Lizi Wu, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Molecular Genetics and Microbiology | Medicine | Cell Signaling; Oncogene; Tumor Suppressor; Noncoding RNA; Lung Cancer; Head and Neck Cancer; Leukemia; Mouse Tumor Model; Cancer Therapeutics | |
Mansi Dalal, MD | myNCBI | Mechanisms of Oncogenesis (MOO) | Clinical Assistant Professor | Pediatrics | Medicine | Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma; Pediatric Oncology | |
Margaret (Peggy) Wallace, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Molecular Genetics and Microbiology | Lab | Medicine | Bone & Soft Tissue Sarcomas; Breast; Cancer Genetics; DNA Damage & Repair; Epigenetics & Cancer; Genetic Determinants of Cancer; Head & Neck; Hematologic Malignancies/Blood & Marrow Transplant; Skin/Melanoma; Vascular Targeting |
Matthew Eddy, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Chemistry | Liberal Arts and Sciences | ||
Melike Caglayan, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Biochemistry and Molecular Biology | Lab | Medicine | Chemotherapy; DNA Damage & Repair; DNA Replication; Drug Design |
Michael Kladde, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Biochemistry and Molecular Biology | Lab | Medicine | Cancer Epigenetics; Colorectal & Breast Cancer; Glioblastoma; Cell Signaling Pathways |
Michael McIntosh, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Pediatrics | Medicine | Bioinformatics; Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Lymphoma; Tumor Virology/Virus-Host Interactions | |
Mingyi Xie, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Biochemistry and Molecular Biology | Lab | Medicine | Bioinformatics; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; MicroRNAs; RNA Processing; Tumor Virology/Virus-Host Interactions |
Oleksandr Kondratov, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Research Assistant Professor | Pediatrics | Medicine | Epigenetics & Cancer; Gene Therapy | |
Olga Guryanova, MD, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Pharmacology and Therapeutics | Medicine | Cancer Genetics; Cancer Susceptibility; Cell Signaling Pathways; DNA Damage & Repair; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Stem Cell | |
Patrick Griffin, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Scripps Biomedical Research | Medicine | Breast; Drug Design | |
Piyush Jain, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Chemical Engineering | Lab | Engineering | Cancer Genetics; DNA Damage & Repair; DNA Recombination; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Gene Therapy; Nanotechnology; Noninvasive Imaging/Tomography; RNA Processing; Targeted Cancer Therapy |
Rene Opavsky, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Anatomy and Cell Biology | Medicine | Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma | |
Rhonda Bacher, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Biostatistics | Public Health and Health Professions | Bioinformatics; Biostatistics | |
Richard Bennett, PhD | Mechanisms of Oncogenesis (MOO) | Research Associate Professor | Medicine | Medicine | Apoptosis & Cell Death Pathways; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Leukemia; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions | ||
Robert McKenna, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Biochemistry and Molecular Biology | Lab | Medicine | Targeted Cancer Therapy; Gene Therapy; Oncolytic Viral Vectors |
Rolf Renne, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Molecular Genetics and Microbiology | Lab | Medicine | Noncoding RNAs; Cell Signaling Pathways; Lymphoma; Skin/Melanoma; Tumor Virology/Virus-Host Interactions |
Rui Xiao, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Aging and Geriatric Research | Medicine | Transcription Factors; Aging; Cellular Stress Response; Sensory Modulation of Aging; Environmental Factors | |
Rui Yin, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Health Outcomes and Biomedical Informatics | Medicine | Bioinformatics; Cancer Genetics; Drug Design; Genetic Determinants of Cancer; Health Disparities; MicroRNAs, Tumor Virology/Virus-Host Interactions | |
Ryan Kolb, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Pathology, Immunology and Laboratory Medicine | Medicine | Targeted Cancer Therapy; Vascular Targeting; Breast; Angiogenesis; Drug Resistance; Immunoregulation & Suppression; Immunotherapy; Kidney |
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Sara Falzarano, MD, PhD | Mechanisms of Oncogenesis (MOO) | Clinical Associate Professor | Pathology, Immunology and Laboratory Medicine | Medicine | Cancer Genetics; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Genital-Urinary/Prostate; Kidney | ||
Scott Tibbetts, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Molecular Genetics and Microbiology | Lab | Medicine | Virology/Virus-Host Interactions; Noncoding RNAs; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Infection Control; Leukemia; Lymphoma; MicroRNAs; Stem Cell; Tumor |
Sergei Zolotukhin, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Pediatrics | Lab | Medicine | AAV Biology; Cancer Gene Therapy |
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Shuang Huang, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Anatomy and Cell Biology | Medicine | Breast; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Gene Regulation; Gynecological; Metastasis; MicroRNAs; RNA Processing | |
Sumita Bhaduri-McIntosh, MD, PhD | Mechanisms of Oncogenesis (MOO) | Associate Professor | Pediatrics | Medicine | Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Tumor Virology/Virus-Host Interactions | ||
Susmita Datta, PhD, MBA, MS | Mechanisms of Oncogenesis (MOO) | Professor | Biostatistics | Public Health and Health Professions | Bioinformatics; RNA processing | ||
Thomas Schmittgen, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Pharmaceutics | Lab | Pharmacy | Cancer Genetics; Drug Design; Gastro-Intestinal; Head & Neck; Health Disparities; Liver; MicroRNAs; Nanotechnology | |
Timothy Garrett, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Pathology & Laboratory Medicine | Medicine | Bioinformatics; Breast; Cancer Surveillance; Genital-Urinary/Prostate; Kidney; Tumor Virology/Virus-Host Interactions | |
Walter Murfee, PhD | Mechanisms of Oncogenesis (MOO) | Associate Professor | Biomedical Engineering | Lab | Engineering | Angiogenesis; Stem Cell; Targeted Cancer Therapy; Vascular Targeting |
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Xiao Fan, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Biomedical Engineering | https://xiaofan-lab.github.io/ | Engineering | Bioinformatics; Biostatistics; Cancer Genetics; Cancer Information; Cancer Susceptibility; Genetic Determinants of Cancer; Post-Transcriptional Gene Regulation |
Xin Tang, PhD | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Mechanical Aerospace Engineering | Engineering | Angiogenesis; Breast; Epigenetics & Cancer; Immunoregulation & Suppression; Immunotherapy; Integrative Medicine; Metastasis; Nanotechnology; Noninvasive Imaging/Tomography; Vascular Targeting | ||
Yehia Daaka, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Anatomy and Cell Biology | Medicine | Androgen receptors; Human pathophysiology receptors | |
Zhe Ma, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Assistant Professor | Molecular Genetics and Microbiology | Lab | Medicine | |
Zhijian Qian, PhD | Mechanisms of Oncogenesis (MOO) | Professor | Medicine | Medicine | Cancer Genetics; Cell Signaling Pathways; Drug Resistance; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Stem Cell | ||
Zsolt Toth, PhD | myNCBI | Mechanisms of Oncogenesis (MOO) | Associate Professor | Oral Biology | Lab | Dentistry | Cancer Genetics; Epigenetics & Gene Regulation; Immunoregulation & Suppression; Infection Control; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions |
Matthew Gentry | myNCBI | Mechanisms of Oncogenesis (MOO) | Professor | Department of Biochemistry and Molecular Biology | Medicine | Drug Design; Environment; Epigenetics & Cancer; Health Disparities; Lung; Pediatric Oncology |
