Mechanisms of Oncogenesis

A man in a white coat works at a laboratory bench.

The mission of the Mechanisms of Oncogenesis (MOO) program at the University of Florida Health Cancer Center is to understand how normal cells undergo complex changes leading to cancer. The scientific objectives of the MOO program are to elucidate the deregulated genetic and epigenetic events that drive tumor initiation and progression and develop new cancer targeting strategies.

The research aims focus on identifying and characterizing genetic and epigenetic alterations, elucidating the role of noncoding RNAs in cancer, studying oncogenic mechanisms of DNA tumor viruses, and translating MOO discovery to novel therapeutic approaches.

Aims

The aims of the MOO program are to elucidate the role of genetic and epigenetic alterations in cancer; define the role of regulatory microRNAs and long noncoding RNAs in oncogenesis; and translate MOO discoveries into novel therapeutic approaches.

Program Members

To request an update, please email ResearchDevelopment@cancer.ufl.edu.

NamemyNCBI LinkResearch ProgramTitleDepartmentLab PageCollegeResearch Interest Topics
Alberto Perez, PhD

perez
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorChemistryLabLiberal Arts and SciencesBioinformatics; Epigenetics & Gene Regulation
Alexander Ishov, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy and Cell BiologyMedicineBreast; Prostate; Cancer Genetics; Chemotherapy; Epigenetics & Cancer
Arun Srivastava, PhD, BSc, MSc

myNCBIMechanisms of Oncogenesis (MOO)ProfessorPediatricsLabMedicineGene Therapy; AAV Biology; Liver; Stem Cell; Targeted Cancer Therapy; Tumor Virology/Virus-Host Interactions
Bernadett Papp, PhD

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorOral BiologyLabDentistryBioinformatics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Stem Cell; Tumor Virology/Virus-Host interactions
Bowen Yan, PhD

 Bowen Yan
myNCBIMechanisms of Oncogenesis (MOO)Research Assistant ProfessorPharmacology and TherapeuticsMedicineHematologic Malignancies; Blood & Marrow Transplant
Charles Baer, PhD

Mechanisms of Oncogenesis (MOO)ProfessorBiologyLabLiberal Arts and SciencesEvolutionary Biology; Population Genetics; Quantitative Genetics
Chenglong Li, PhD

Mechanisms of Oncogenesis (MOO)ProfessorMedicinal ChemistryPharmacyCell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Neuro-Oncology; Pediatric Oncology; Stem Cell; Targeted Cancer Therapy
Christopher Vulpe, MD, PhD

Mechanisms of Oncogenesis (MOO)ProfessorPhysiological SciencesLabVeterinary MedicineApoptosis & Cell Death Pathways; Breast; Cancer Genetics; Chemotherapy; DNA Damage & Repair; Drug Resistance; Environment; Leukemia; Pediatric Oncology; CRSPR; Synthetic Lethal Screens; Precision Medicine
Cleverson De Souza, DVM, MS, PhD, DACVP

 Cleverson De Souza
Mechanisms of Oncogenesis (MOO)Associate ProfessorComparative, Diagnostic, & Population MedicineVeterinary MedicineImmunoregulation & Suppression; Immunotherapy; Leukemia; Lymphoma; Nanotechnology
Courtney Miller, PhD

Miller
myNCBIMechanisms of Oncogenesis (MOO)ProfessorScripps Biomedical ResearchMedicineHead & Neck; Neuro-Oncology
Daiqing Liao, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy and Cell BiologyMedicineApoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Chemotherapy; Drug Design; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genital-Urinary/Prostate; Immunoregulation & Suppression; Tumor Virology/Virus-Host Interactions
David Bloom, PhD

Mechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics and MicrobiologyMedicineEpigenetics & Cancer; Oncolytic Viral Vectors; Tumor Virology/Virus-Host Interactions
Dietmar Siemann, PhD

Mechanisms of Oncogenesis (MOO)ProfessorRadiation OncologyLabMedicineBreast; Cell Signaling Pathways; Chemotherapy; Drug Design; Environment; Genital-Urinary/Prostate; Metastasis; Radiation Oncology; Stem Cell; Targeted Cancer Therapy; Vascular Targeting
Gary Wang, MD, PhD

Mechanisms of Oncogenesis (MOO)ProfessorMedicineMedicineBioinformatics; Gene Therapy; Liver
Jason Brant, PhD

brant
Mechanisms of Oncogenesis (MOO)Research Assistant ProfessorPathology, Immunology and Laboratory MedicineMedicineBioinformatics; Epigenetics & Cancer; Epigenetics & Gene Regulation
Jason Butler, PhD

Butler
Mechanisms of Oncogenesis (MOO)ProfessorMedicineMedicineAngiogenesis; Cell Signaling Pathways; Chemotherapy; DNA Damage & Repair; Hematologic Malignancies/Blood & Marrow Transplant; Stem Cell; Vascular Targeting
Jia Chang, DDS

chang

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorPeriodontologyDentistryBone & Soft Tissue (Sarcoma); Bioinformatics; Post-Transcriptional Gene Regulation; Stem Cell; Biostatistics; Angiogenesis
Jianrong Lu, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorBiochemistry and Molecular BiologyMedicineAngiogenesis; Apoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Metastasis; Post-Transcriptional Gene Regulation
Jonathan Licht, MD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMedicineLabMedicineDNA Damage & Repair; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Jorg Bungert, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorBiochemistry and Molecular BiologyLabMedicineEpigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Juan Guan, PhD

guan

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorPhysicsLiberal Arts and SciencesCancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Drug Design; Nanotechnology
Julie Maupin, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMicrobiology & Cell ScienceAgricultural and Life SciencesMicrobiology; Cell Signaling Pathways
Kate Carroll, PhD

Carroll
Mechanisms of Oncogenesis (MOO)ProfessorScripps Biomedical ResearchMedicineCell Signaling Pathways; Drug Design
Katrin Karbstein, PhD

 Katrin Karbstein

myNCBI
Mechanisms of Oncogenesis (MOO)ProfessorIntegrative Structural and Computational BiologyMedicineMolecular Chaperones; Post-Transcriptional Gene Regulation; RNA Processing
Kiley Graim, PhD

Graim

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorComputer and Information Science and EngineeringEngineeringBioinformatics; Genetic Determinants of Cancer
Kristianna Fredenburg, MD, PhD


Mechanisms of Oncogenesis (MOO)Assistant ProfessorPathology, Immunology and Laboratory MedicineMedicineHead & Neck; microRNAs; cancer disparities
Lauren McIntyre, PhD

McIntyre
Mechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics and MicrobiologyMedicineBioinformatics; Biostatistics; Cancer Genetics; Epigenetics & Gene Regulation; Nanotechnology; RNA Processing; Structural Virology
Lizi Wu, PhD

Wu
myNCBIMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics and MicrobiologyMedicineCell Signaling; Oncogene; Tumor Suppressor; Noncoding RNA; Lung Cancer; Head and Neck Cancer; Leukemia; Mouse Tumor Model; Cancer Therapeutics
Mansi Dalal, MD

Dalal
myNCBIMechanisms of Oncogenesis (MOO)Clinical Assistant ProfessorPediatricsMedicineEpigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma; Pediatric Oncology
Margaret (Peggy) Wallace, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics and MicrobiologyLabMedicineBone & Soft Tissue Sarcomas; Breast; Cancer Genetics; DNA Damage & Repair; Epigenetics & Cancer; Genetic Determinants of Cancer; Head & Neck; Hematologic Malignancies/Blood & Marrow Transplant; Skin/Melanoma; Vascular Targeting
Matthew Eddy, PhD
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorChemistryLiberal Arts and Sciences
Melike Caglayan, PhD

Caglayan

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorBiochemistry and Molecular BiologyLabMedicineChemotherapy; DNA Damage & Repair; DNA Replication; Drug Design
Michael Kladde, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorBiochemistry and Molecular BiologyLabMedicineCancer Epigenetics; Colorectal & Breast Cancer; Glioblastoma; Cell Signaling Pathways
Michael McIntosh, PhD

Mcintosh
myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorPediatricsMedicineBioinformatics; Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Lymphoma; Tumor Virology/Virus-Host Interactions
Mingyi Xie, PhD

Xie

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorBiochemistry and Molecular BiologyLabMedicineBioinformatics; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; MicroRNAs; RNA Processing; Tumor Virology/Virus-Host Interactions
Oleksandr Kondratov, PhD

Kondratov
myNCBIMechanisms of Oncogenesis (MOO)Research Assistant ProfessorPediatricsMedicineEpigenetics & Cancer; Gene Therapy
Olga Guryanova, MD, PhD

Guryanova

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorPharmacology and TherapeuticsMedicineCancer Genetics; Cancer Susceptibility; Cell Signaling Pathways; DNA Damage & Repair; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Stem Cell
Patrick Griffin, PhD

Griffin Patrick
myNCBIMechanisms of Oncogenesis (MOO)ProfessorScripps Biomedical ResearchMedicineBreast; Drug Design
Piyush Jain, PhD

Jain
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorChemical EngineeringLabEngineeringCancer Genetics; DNA Damage & Repair; DNA Recombination; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Gene Therapy; Nanotechnology; Noninvasive Imaging/Tomography; RNA Processing; Targeted Cancer Therapy
Rene Opavsky, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorAnatomy and Cell BiologyMedicineEpigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Rhonda Bacher, PhD

myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorBiostatisticsPublic Health and Health ProfessionsBioinformatics; Biostatistics
Richard Bennett, PhD

Mechanisms of Oncogenesis (MOO)Research Associate ProfessorMedicineMedicineApoptosis & Cell Death Pathways; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Leukemia; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions
Robert McKenna, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorBiochemistry and Molecular BiologyLabMedicineTargeted Cancer Therapy; Gene Therapy; Oncolytic Viral Vectors
Rolf Renne, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics and MicrobiologyLabMedicineNoncoding RNAs; Cell Signaling Pathways; Lymphoma; Skin/Melanoma; Tumor Virology/Virus-Host Interactions
Rui Xiao, PhD

Xiao
myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorAging and Geriatric ResearchMedicineTranscription Factors; Aging; Cellular Stress Response; Sensory Modulation of Aging; Environmental Factors
Rui Yin, PhD

Yin
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorHealth Outcomes and Biomedical InformaticsMedicineBioinformatics; Cancer Genetics; Drug Design; Genetic Determinants of Cancer; Health Disparities; MicroRNAs, Tumor Virology/Virus-Host Interactions
Ryan Kolb, PhD

Kolb
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorPathology, Immunology and Laboratory MedicineMedicineTargeted Cancer Therapy; Vascular Targeting; Breast; Angiogenesis; Drug Resistance; Immunoregulation & Suppression; Immunotherapy; Kidney
Sara Falzarano, MD, PhD

Falzarano

Mechanisms of Oncogenesis (MOO)Clinical Associate ProfessorPathology, Immunology and Laboratory MedicineMedicineCancer Genetics; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Genital-Urinary/Prostate; Kidney
Scott Tibbetts, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorMolecular Genetics and MicrobiologyLabMedicineVirology/Virus-Host Interactions; Noncoding RNAs; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Infection Control; Leukemia; Lymphoma; MicroRNAs; Stem Cell; Tumor
Sergei Zolotukhin, PhD

Mechanisms of Oncogenesis (MOO)ProfessorPediatricsLabMedicineAAV Biology; Cancer Gene Therapy
Shuang Huang, PhD

myNCBIMechanisms of Oncogenesis (MOO)ProfessorAnatomy and Cell BiologyMedicineBreast; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Gene Regulation; Gynecological; Metastasis; MicroRNAs; RNA Processing
Sumita Bhaduri-McIntosh, MD, PhD



Mechanisms of Oncogenesis (MOO)Associate ProfessorPediatricsMedicineCancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Tumor Virology/Virus-Host Interactions
Susmita Datta, PhD, MBA, MS

Mechanisms of Oncogenesis (MOO)ProfessorBiostatisticsPublic Health and Health ProfessionsBioinformatics; RNA processing
Thomas Schmittgen, PhD

Schmittgen
Mechanisms of Oncogenesis (MOO)ProfessorPharmaceuticsLabPharmacyCancer Genetics; Drug Design; Gastro-Intestinal; Head & Neck; Health Disparities; Liver; MicroRNAs; Nanotechnology
Timothy Garrett, PhD

Garrett
myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorPathology & Laboratory MedicineMedicineBioinformatics; Breast; Cancer Surveillance; Genital-Urinary/Prostate; Kidney; Tumor Virology/Virus-Host Interactions
Walter Murfee, PhD

Mechanisms of Oncogenesis (MOO)Associate ProfessorBiomedical EngineeringLabEngineeringAngiogenesis; Stem Cell; Targeted Cancer Therapy; Vascular Targeting
Xiao Fan, PhD

Xiao Fan
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorBiomedical Engineeringhttps://xiaofan-lab.github.io/EngineeringBioinformatics; Biostatistics;
Cancer Genetics;
Cancer Information;
Cancer Susceptibility;
Genetic Determinants of Cancer;
Post-Transcriptional Gene Regulation
Xin Tang, PhD

Mechanisms of Oncogenesis (MOO)Assistant ProfessorMechanical Aerospace EngineeringEngineeringAngiogenesis; Breast; Epigenetics & Cancer; Immunoregulation & Suppression; Immunotherapy; Integrative Medicine; Metastasis; Nanotechnology; Noninvasive Imaging/Tomography; Vascular Targeting
Yehia Daaka, PhD

daaka
myNCBIMechanisms of Oncogenesis (MOO)ProfessorAnatomy and Cell BiologyMedicineAndrogen receptors; Human pathophysiology receptors
Zhe Ma, PhD
myNCBIMechanisms of Oncogenesis (MOO)Assistant ProfessorMolecular Genetics and MicrobiologyLabMedicine
Zhijian Qian, PhD

Qian
Mechanisms of Oncogenesis (MOO)ProfessorMedicineMedicineCancer Genetics; Cell Signaling Pathways; Drug Resistance; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Stem Cell
Zsolt Toth, PhD

myNCBIMechanisms of Oncogenesis (MOO)Associate ProfessorOral BiologyLabDentistryCancer Genetics; Epigenetics & Gene Regulation; Immunoregulation & Suppression; Infection Control; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions
Matthew Gentry

 Matthew Gentry
myNCBIMechanisms of Oncogenesis (MOO)ProfessorDepartment of Biochemistry and Molecular BiologyMedicineDrug Design; Environment; Epigenetics & Cancer; Health Disparities; Lung; Pediatric Oncology
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