Mechanisms of Oncogenesis (MOO)

Mission

The mission of the Mechanisms of Oncogenesis (MOO) program is to define the molecular pathways by which normal cells transform to neoplasia in order to identify new methods of cancer prevention and treatment.

Aims

  • Elucidate the origins of neoplastic genomic and epigenomic instability

  • Define the role of regulatory RNAs in oncogenisis

  • Illuminate the aberrant cell signaling pathways leading to neoplastic transformation

Interim Program Leader

Rolf Renne, Ph.D.

Rolf Renne, Ph.D., is the interim program leader of the Mechanisms of Oncogenesis (MOO) program.

For nearly 13 years, Dr. Renne has served as a professor in the UF College of Medicine’s department of molecular genetics and microbiology, studying the Kaposi sarcoma-associated herpesvirus — which has been his research focus since 1995. His laboratory uses genomics, genetics and ribonomics approaches to study how virally-encoded genes and microRNAs contribute to KSHV biology and tumorigenesis.

Dr. Renne received his master’s and Ph.D. degrees from the Albert-Ludwigs University of Freiburg, Germany. He performed most of his Ph.D. thesis work at UC Davis with Dr. Paul Luciw in the field of retrovirology. Next, he joined the laboratory of Dr. Don Ganem at UCSF where he contributed to early work on establishing tissue culture models for KSHV, which had recently been identified as the causative pathogen for Kaposi sarcoma in patients with AIDS.

In 1999, he joined the faculty at Case Western Reserve University, where he focused on molecular aspects such as the role of the KSHV latency-associated nuclear antigen (LANA) in DNA binding and latent DNA replication. He established the only available Kaposi sarcoma xenograft model. In 2004, he moved to UF where his laboratory was one of four worldwide to sequence and identify KSHV-encoded microRNAs. 

The unifying goal of Dr. Renne’s research has been to achieve a deeper understanding of how latent gamma-herpesvirus gene products, including microRNAs and long noncoding RNAs, contribute to viral tumorigenesis of AIDS malignancies. His current focus is on epigenetic regulation of viral latency, and the role of long and small non-coding RNAs in viral biology. 

Dr. Renne has been continuously funded by multiple NCI grants since 2004. In 2017, he was awarded a multi-investigator NCI Program Project together with Scott Tibbetts, Ph.D., an associate professor at UF, and Erik Flemington, Ph.D., a professor at Tulane University.

He serves on the editorial boards of the Journal of Virology and Virology and has authored more than 80 peer-reviewed articles. In 2009, Dr. Renne co-chaired the 11th International Workshop on KSHV and related agents as well as the 40th International Herpesvirus Workshop in Boise, Idaho in 2015. He serves on multiple NIH special emphasis panels. 

Program Members
To request an update, please email ResearchAdmin@cancer.ufl.edu.

Last NameDegree(s)TitleDepartmentCollegeResearch Interest Topics
Baer, Charles F.

Ph.DAssistant ProfessorBiologyLiberal Arts & SciencesEvolutionary Biology; Population Genetics; Quantitative Genetics; Mutation
Bennett, Richard L.

Ph.DResearch Assistant ProfessorHematology & OncologyMedicineApoptosis & Cell Death Pathways; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Leukemia; Post-Transcriptional Gene Regulation; RNA Processing; and Tumor.
Berglund, J. Andy

Ph.DProfessorNeuroGeneticsMedicineBioinformatics; Genetic Determinants of Cancer; Post-Transcriptional; RNA Processing.
Bloom, David C.

Ph.DProfessorMolecular Genetics & MicrobiologyMedicineEpigenetics & Cancer; Epigenetics & Gene Regulation; Gene Therapy; miRNAs Oncolytic Viral Vectors; Tumor Virology/Virus-Host Interactions
Brown, Kevin D.

Ph.DAssociate ProfessorBiochemistry & Molecular BiologyMedicine
Bungert, Jorg

Ph.DProfessorBiochemistry & Molecular BiologyMedicineEpigenetics & Gene Regulation; and Hematologic Malignancies/Blood & Marrow Transplant.
Concannon, Patrick

Ph.DProfessorPathology, Immunology & Laboratory MedicineMedicineMedicine
Datta, Susmita

Ph.DProfessorBiostatisticsPublic Health & Health Professions
Frost, Susan

Ph.DProfessorBiochemistry & Molecular BiologyMedicineBreast; Chemotherapy; Environment
Guryanova, Olga

Ph.D, M.D.Assistant ProfessorPharmacology & TherapeuticsMedicineCancer genetics; Cancer Susceptibility; Cell Signaling Pathways; DNA Damage & Repair; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Stem Cell.
Huang, Shuang

Ph.DProfessorAnatomy & Cell BiologyMedicineBreast; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Gene Regulation; Gynecological; Metastasis; MicroRNAs; and RNA Processing.
Ishov, Alexander M.

Ph.DAssociate ProfessorAnatomy & Cell BiologyMedicineBreast; Cancer Genetics; Chemotherapy; Epigenetics & Cancer; Functions of Histone Variants in Castration-Resistant Prostate Cancer; Chemoresistance in Breast Cancer; Nuclear Structure and Function; Epigenetic Regulation of Gene Expression; Tumor Suppression.
Jiang, Qiu-Xing

Ph.DAssociate ProfessorMicrobiology & Cell ScienceAgriculture & Life SciencesEndocrine; Neuroendocrine Cancers; Cancer Genetics; MicroRNAs; Nanotechnology; Structural Biology
Kaye, Frederic J.

M.D.ProfessorHematology & OncologyMedicineCancer Genetics; Cell Signaling Pathways; Genetic Determinants of Cancer; Head & Neck; Lung; and Thoracic Oncology.
Kilberg, Michael S.

Ph.DProfessorBiochemistry & Molecular BiologyMedicineCell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Leukemia; Liver; and Post-Transcriptional Gene Regulation.
Kladde, Michael P.

Ph.DAssociate ProfessorBiochemistry & Molecular BiologyMedicineBreast; Cell Signaling Pathways; Epigenetics & Cancer.
Lele, Tanmay P.

Ph.DAssociate ProfessorChemical EngineeringEngineeringAngiogenesis; Breast; Epigenetics & Cancer; Epigenetics & Gene Regulation; MicroRNAs; Nanotechnology; RNA Processing.
Li, Chenglong

Ph.DProfessorMedicinal ChemistryPharmacyCell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Cancer; Hematolog Malignancies/Blood & Marrow Transplant; Immunotherapy; Neuro-Oncology; Pediatric Oncology; Stem Cell; Targeted Cancer Therapy.
Liao, Diaqing

Ph.DAssociate ProfessorAnatomy & Cell BiologyMedicineApoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cancer Metabolism; Cell Signaling Pathways; Chemotherapy; Drug Design; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genital-Urinary/Prostate; Immunoregulation & Suppression; and Tumor Virology/Virus-Host Interactions.
Licht, Jonathan D.

M.D.ProfessorHematology & OncologyMedicineDNA Damage & Repair; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma.
Ling, Chen

Ph.DResearch Assistant ProfessorPediatric ResearchMedicineGene Therapy
Lu, Jianrong

Ph.DAssociate ProfessorBiochemistry & Molecular BiologyMedicineAngiogenesis; Apoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Gene Determinants of Cancer; Metastasis; and Post-Transcriptional Gene Regulation.
Michailidis, George

Ph.DProfessorInformatics InstitutePublic Health & Health Professions
Opavsky, Rene

Ph.DAssociate ProfessorAnatomy & Cell BiologyMedicineEpigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Papp, Bernadett

Ph.DResearch Assistant ProfessorOral BiologyDentistryBioinformatics; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation; Stem Cell; Tumor Virology/Virus-Host interactions
Qiu, Yi

Ph.DAssistant ProfessorAnatomy & Cell BiologyMedicineEpigenetics & Cancer
Renne, Rolf F.

Ph.DProfessorMolecular Genetics & MicrobiologyMedicineCell Signaling Pathways; DNA Damage & Repair; Lymphoma; Skin/Melanoma; and Tumor Virology/Virus-Host Interactions.
Srivastava, Arun

Ph.D, BSc, MScProfessorPediatric ResearchMedicineHematologic Malignancies/Blood & Marrow Transplant; Liver; Stem Cell; Targeted Cancer Therapy; Tumor Virology/Virus-Host Interactions.
Terada, Naohiro

Ph.D, M.D.ProfessorPathologyMedicineAngiogenesis; Cell Signaling Pathways; and Stem Cell.
Tibbetts, Scott

Ph.DAssociate ProfessorMolecular Genetics & MicrobiologyMedicineApoptosis & Cell Death Pathways; Epigenetics & Cancer; Epigenetics & Gener Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Infection Control; Leukemia; Lymphoma; MicroRNAs; Stem Cell; Tumor Virology/Virus-Host Interactions.
Toth, Zsolt

Ph.DAssistant ProfessorOral BiologyDentistryAngiogenesis; Cancer Genetics; Epigenetics & Gene Regulation; Immunoregulation & Suppression; Infection Control; Lymphoma; Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions.
Wang, Gary P.

Ph.D, M.D.Associate ProfessorInfectious DiseaseMedicineBioinformatics; Gene Therapy; Liver
Wu, Lizi

Ph.DAssociate ProfessorMolecular Genetics & MicrobiologyMedicineApoptosis & Cell Death Pathways; Breast; Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Drug Design; Epigenetics & Cancer; Gynecological; Leukemia; Tumor Virology/Virus-Host Interactions.
Xiao, Rui


PhDAssistant ProfessorAging & Geriatric ResearchMedicineTranscription Factors; Aging; Cellular Stress Response; Sensory Modulation of Aging; Environmental Factors
Xie, Mingyi

Ph.DAssistant ProfessorBiochemistry & Molecular BiologyMedicineBioinformatics; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; MicroRNAs; RNA Processing; Tumor Virology/Virus-Host Interactions.
Yang, Thomas P.

Ph.DProfessorBiochemistry & Molecular BiologyMedicine
Zajac-Kaye, Maria

Ph.DProfessorAnatomy & Cell BiologyMedicineOncogenes & Tumor Suppressor Genes; Pancreatic Cancer; DNA Replication and Repair; Oncolytic Viral Therapy; Lung Cancer; Genetically Engineered Mice Models.
Zhou, Lei

Ph.D, BMedAssociate ProfessorMolecular Genetics & MicrobiologyMedicineApoptosis & Cell Death Pathways; Bioinformatics; Cancer Genetics; Epigenetics & Cancer; Genetic Determinants of Cancer; Epigenetics & Gene Regulation; Radiation Oncology; Senescence.
Zolotukhin, Sergei

Ph.DProfessorPediatric ResearchMedicineGene Therapy
Tang, Xin


Ph.DAssistant ProfessorMechanical & Aerospace EngineeringEngineeringAngiogenesis; Breast; Epigenetics & Cancer; Immunoregulation & Suppression; Immunotherapy; Integrative Medicine; Metastasis; Nanotechnology; Noninvasive Imaging/Tomography; Vascular Targeting