Mechanisms of Oncogenesis

Mission

The mission of the Mechanisms of Oncogenesis (MOO) program at the University of Florida Health Cancer Center is to understand how normal cells undergo complex changes leading to cancer.

The scientific objectives of the MOO program are to elucidate the deregulated genetic and epigenetic events that drive tumor initiation and progression and develop new cancer targeting strategies.

The research aims focus on identifying and characterizing genetic and epigenetic alterations, elucidating the role of noncoding RNAs in cancer, studying oncogenic mechanisms of DNA tumor viruses, and translating MOO discovery to novel therapeutic approaches.

Program Members

To request an update, please email ResearchDevelopment@cancer.ufl.edu.

Name	myNCBI	Research Program	Title	Department	Lab Page	College	Research Topic Interest
Bacher, Rhonda, PhD	myNCBI	MOO	Assistant Professor	Biostatistics		Public Health and Health Professions	Bioinformatics; Biostatistics
Baer, Charles F, PhD		MOO	Professor	Biology		Liberal Arts and Sciences	Population Genetics; Quantitative Genetics; Evolutionary Biology
Bennett, Richard L, PhD	myNCBI	MOO	Research Associate Professor	Medicine		Medicine	Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; Apoptosis & Cell Death Pathways; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Leukemia; Lymphoma
Bhaduri-McIntosh, Sumita, MD, PhD		MOO	Associate Professor	Pediatrics		Medicine	Tumor Virology/Virus-Host Interactions; Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Bloom, David C, PhD		MOO	Professor	Molecular Genetics and Microbiology		Medicine	Tumor Virology/Virus-Host Interactions; Epigenetics & Cancer; Oncolytic Viral Vectors
Brant, Jason, PhD		MOO	Research Assistant Professor	Pathology, Immunology and Laboratory Medicine		Medicine	Bioinformatics; Epigenetics & Cancer; Epigenetics & Gene Regulation
Bungert, Jorg, PhD	myNCBI	MOO	Professor	Biochemistry and Molecular Biology	Lab	Medicine	Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Butler, Jason, PhD		MOO	Professor	Medicine		Medicine	Angiogenesis; Cell Signaling Pathways; Chemotherapy; DNA Damage & Repair; Hematologic Malignancies/Blood & Marrow Transplant; Stem Cell; Vascular Targeting
Caglayan, Melike, PhD	myNCBI	MOO	Assistant Professor	Biochemistry and Molecular Biology	Lab	Medicine	Chemotherapy; DNA Damage & Repair; DNA Replication; Drug Design
Chen, Li, PhD		MOO	Associate Professor	Biostatistics		Public Health and Health Professions	Bioinformatics; Biostatistics; Cancer Genetics; Cancer Information; Epigenetics & Cancer; Epigenetics & Gene Regulation
Cleverson de Souza, DVM, MS, PhD, DACVP	myNCBI	MOO	Associate Professor	Comparative, Diagnostic, & Population Medicine		Veterinary Medicine	Immunoregulation & Suppression; Immunotherapy; Leukemia; Lymphoma; Nanotechnology
Daaka, Yehia, PhD	myNCBI	MOO	Professor	Anatomy and Cell Biology		Medicine	Androgen Receptors; Human Pathophysiology Receptors
Dalal, Mansi, MD	myNCBI	MOO	Clinical Assistant Professor	Pediatrics		Medicine	Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma; Pediatric Oncology
Datta, Susmita, PhD	myNCBI	MOO	Professor	Biostatistics		Public Health and Health Professions	Bioinformatics; RNA Processing
Eddy, Matthew, PhD	myNCBI	MOO	Assistant Professor	Chemistry		Liberal Arts and Sciences	Chemical biology; G-protein-coupled receptors
Falzarano, Sara, MD, PhD		MOO	Clinical Associate Professor	Pathology, Immunology and Laboratory Medicine		Medicine	Cancer Genetics; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Genital-Urinary/Prostate; Kidney
Fan, Xiao, PhD	myNCBI	MOO	Assistant Professor	Biomedical Engineering	Lab	Engineering	Bioinformatics; Biostatistics; Cancer Genetics; Cancer Information; Cancer Susceptibility; Genetic Determinants of Cancer; Post-Transciptional Gene Reguation
Fredenburg, Kristianna , MD, PhD	myNCBI	MOO	Assistant Professor	Pathology, Immunology and Laboratory Medicine		Medicine	Cancer Disparities; Head & Neck; MicroRNAs
Garrett, Timothy, PhD	myNCBI	MOO	Associate Professor	Pathology, Immunology and Laboratory Medicine		Medicine	Bioinformatics; Breast; Cancer Surveillance; Genital-Urinary/Prostate; Kidney; Tumor Virology/Virus-Host Interactions
Gentry, Matthew, PhD	myNCBI	MOO	Professor	Biochemistry and Molecular Biology		Medicine	Drug Design; Environment; Epigenetics & Cancer; Health Disparities; Lung; Pediatric Oncology
Graim, Kiley, PhD	myNCBI	MOO	Assistant Professor	Computer and Information Science and Engineering		Engineering	Bioinformatics; Genetic Determinants of Cancer
Griffin, Patrick, PhD	myNCBI	MOO	Professor	Scripps Biomedical Research		Medicine	Breast; Drug Design
Guryanova, Olga, MD, PhD	myNCBI	MOO	Assistant Professor	Pharmacology and Therapeutics		Medicine	Stem Cell; Cancer Genetics; Cancer Susceptibility; Cell Signaling Pathways; DNA Damage & Repair; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia
Huang, Shuang, PhD	myNCBI	MOO	Professor	Anatomy and Cell Biology		Medicine	RNA Processing; Breast; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Gene Regulation; Gynecological; Metastasis; MicroRNAs
Ishov, Alexander M, PhD	myNCBI	MOO	Associate Professor	Anatomy and Cell Biology		Medicine	Prostate Cancer; Breast; Cancer Genetics; Chemotherapy; Epigenetics & Cancer
Jain, Piyush, PhD	myNCBI	MOO	Assistant Professor	Chemical Engineering	Lab	Engineering	RNA Processing; Targeted Cancer Therapy; DNA Recombination; Cancer Genetics; DNA Damage & Repair; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Gene Therapy; Nanotechnology; Noninvasive Imaging/Tomography
Kladde, Michael P, PhD	myNCBI	MOO	Professor	Biochemistry and Molecular Biology	Lab	Medicine	Cancer Epigenetics; Cell Signaling Pathways; Colorectal and Breast Cancer; Glioblastoma
Kolb, Ryan, PhD	myNCBI	MOO	Assistant Professor	Pathology, Immunology and Laboratory Medicine		Medicine	Targeted Cancer Therapy; Vascular Targeting; Breast; Angiogenesis; Drug Resistance; Immunoregulation & Suppression; Immunotherapy; Kidney
Kondratov, Oleksandr, PhD	myNCBI	MOO	Research Assistant Professor	Pediatrics		Medicine	Epigenetics & Cancer; Gene Therapy
Kotaro Fujii, PhD	myNCBI	MOO	Assistant Professor	Molecular Genetics and Microbiology		Medicine	Post-Transcriptional Gene Regulation
Li, Chenglong, PhD		MOO	Professor	Medicinal Chemistry		Pharmacy	Pediatric Oncology; Stem Cell; Targeted Cancer Therapy; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Neuro-Oncology
Li, Zhipeng, PhD	myNCBI	MOO	Assistant Professor	Biochemistry and Molecular Biology		Medicine	Apoptosis & Cell Death Pathways; Breast; Cancer Susceptibility; Drug Resistance; Genetic Determinants of Cancer
Liao, Daiqing , PhD	myNCBI	MOO	Associate Professor	Anatomy and Cell Biology		Medicine	Tumor Virology/Virus-Host Interactions; Breast; Cancer Genetics; Cell Signaling Pathways; Chemotherapy; Drug Design; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genital-Urinary/Prostate; Apoptosis & Cell Death Pathways; Immunoregulation & Suppression
Licht, Jonathan D, MD	myNCBI	MOO	Professor	Medicine	Lab	Medicine	DNA Damage & Repair; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Lu, Jianrong, PhD	myNCBI	MOO	Associate Professor	Biochemistry and Molecular Biology		Medicine	Post-Transcriptional Gene Regulation; Breast; Cancer Genetics; Cell Signaling Pathways; Angiogenesis; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Apoptosis & Cell Death Pathways; Metastasis
Ma, Zhe, PhD	myNCBI	MOO	Assistant Professor	Molecular Genetics and Microbiology	Lab	Medicine	Tumor Virology/Virus-Host Interactions
Maupin-Furlow, Julie, PhD	myNCBI	MOO	Professor	Microbiology & Cell Science		Agricultural and Life Sciences	Cell Signaling Pathways; Microbiology
McIntosh, Michael, PhD	myNCBI	MOO	Associate Professor	Pediatrics	Lab	Medicine	Bioinformatics; Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Lymphoma; Tumor Virology/Virus-Host Interactions
McIntyre, Lauren, PhD	myNCBI	MOO	Professor	Molecular Genetics and Microbiology		Medicine	Bioinformatics; Biostatistics; Cancer Genetics; Epigenetics & Gene Regulation; Nanotechnology; RNA Processing; Structural Virology
McKenna, Robert, PhD	myNCBI	MOO	Professor	Biochemistry and Molecular Biology	Lab	Medicine	Targeted Cancer Therapy; Gene Therapy; Oncolytic Viral Vectors
Miller, Courtney, PhD	myNCBI	MOO	Professor	Scripps Biomedical Research		Medicine	Head & Neck; Neuro-Oncology
Moore, Helen, PhD		IOM	Associate Professor	Medicine		Medicine	Cell Signaling Pathways; Chemotherapy; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Immunotherapy; Skin/Melanoma
Murfee, Walter, PhD		MOO	Associate Professor	Biomedical Engineering	Lab	Engineering	Stem Cell; Targeted Cancer Therapy; Vascular Targeting; Angiogenesis
Opavsky, Rene, PhD	myNCBI	MOO	Associate Professor	Anatomy and Cell Biology		Medicine	Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Papp, Bernadett, PhD	myNCBI	MOO	Assistant Professor	Oral Biology		Dentistry	Bioinformatics; Stem Cell; Tumor Virology/Virus-Host Interactions; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation
Perez, Alberto, PhD	myNCBI	MOO	Assistant Professor	Chemistry	Lab	Liberal Arts and Sciences	Bioinformatics; Epigenetics & Gene Regulation
Qian, Zhijian, PhD		MOO	Professor	Medicine		Medicine	Stem Cell; Cancer Genetics; Cell Signaling Pathways; Drug Resistance; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Renne, Rolf F, PhD	myNCBI	MOO	Professor	Molecular Genetics and Microbiology	Lab	Medicine	Skin/Melanoma; Tumor Virology/Virus-Host Interactions; Cell Signaling Pathways; Lymphoma; Noncoding RNAs
Schmittgen, Thomas, PhD		MOO	Professor	Pharmaceutics	Lab	Pharmacy	Cancer Genetics; Drug Design; Gastro-Intestinal; Head & Neck; Health Disparities; Liver; MicroRNAs; Nanotechnology
Soltis, Douglas, PhD		MOO	Distinguished Professor	Biology		Liberal Arts and Sciences	Cancer Genetics
Soltis, Pamela, PhD		MOO	Distinguished Professor	Natural History		School of Natural Resources and Environment	Bioinformatics; Cancer Genetics; Environment
Srivastava, Arun, BSc, MSc, PhD	myNCBI	MOO	Professor	Pediatrics	Lab	Medicine	AAV Biology; Stem Cell; Targeted Cancer Therapy; Tumor Virology/Virus-Host Interactions; Gene Therapy; Liver
Tang, Xin, PhD		MOO	Assistant Professor	Mechanical Aerospace Engineering		Engineering	Vascular Targeting; Breast; Angiogenesis; Epigenetics & Cancer; Immunoregulation & Suppression; Immunotherapy; Integrative Medicine; Metastasis; Nanotechnology; Noninvasive Imaging/Tomography
Tibbetts, Scott, PhD	myNCBI	MOO	Professor	Molecular Genetics and Microbiology		Medicine	Stem Cell; Tumor; Virology/Virus-Host Interactions; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Infection Control; Leukemia; Lymphoma; MicroRNAs; Noncoding RNAs
Toth, Zsolt, PhD	myNCBI	MOO	Associate Professor	Oral Biology		Dentistry	Post-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions; Cancer Genetics; Epigenetics & Gene Regulation; Immunoregulation & Suppression; Infection Control; Lymphoma
Vulpe, Christopher D, MD, PhD		MOO	Professor	Physiological Sciences	Lab	Veterinary Medicine	Pediatric Oncology; Precision Medicine; Synthetic Lethal Screens; Breast; Cancer Genetics; Chemotherapy; CRSPR; DNA Damage & Repair; Drug Resistance; Environment; Apoptosis & Cell Death Pathways; Leukemia
Wallace, Margaret R, PhD	myNCBI	MOO	Professor	Molecular Genetics and Microbiology		Medicine	Skin/Melanoma; Vascular Targeting; Biostatistics Bone & Soft Tissue Sarcomas; Breast; Cancer Genetics; DNA Damage & Repair; Epigenetics & Cancer; Genetic Determinants of Cancer; Head & Neck; Hematologic Malignancies/Blood & Marrow Transplant
Wang, Gary P, MD, PhD		MOO	Professor	Medicine		Medicine	Bioinformatics; Gene Therapy; Liver
Wu, Lizi, PhD	myNCBI	MOO	Professor	Molecular Genetics and Microbiology		Medicine	Cell Signaling; Oncogene; Tumor Suppressor; Noncoding RNA; Lung Cancer; Head and Neck Cancer; Leukemia; Mouse Tumor Model; Cancer Therapeutics
Xiao, Rui, PhD	myNCBI	MOO	Associate Professor	Aging and Geriatric Research		Medicine	Sensory Modulation of Aging; Transcription Factors; Aging; Cellular Stress Response; Environmental Factors
Xie, Mingyi, PhD	myNCBI	MOO	Associate Professor	Biochemistry and Molecular Biology		Medicine	Bioinformatics; RNA Processing; Tumor Virology/Virus-Host Interactions; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; MicroRNAs
Yan, Bowen PhD	myNCBI	MOO	Research Assistant Professor	Pharmacology and Therapeutics		Medicine	Hematologic Malignancies; Blood & Marrow Transplant
Yin, Rui, PhD	myNCBI	MOO	Assistant Professor	Health Outcomes and Biomedical Informatics		Medicine	Bioinformatics; Cancer Genetics; Drug Design; Genetic Determinants of Cancer; Health Disparities; MicroRNAs, Tumor Virology/Virus-Host Interactions
Zhang, Donna, PhD	myNCBI	MOO	Professor	Scripps Biomedical Research		Medicine	Cell Signaling Pathways
Zolotukhin, Sergei, PhD		MOO	Professor	Pediatrics		Medicine	AAV Biology; Cancer Gene Therapy