Mechanisms of Oncogenesis

Mark your calendar

Program Meeting

Fourth Monday of every two months | 12-1 p.m. | Online via Zoom ResearchDevelopment@cancer.ufl.edu

Mission

The mission of the Mechanisms of Oncogenesis (MOO) program at the University of Florida Health Cancer Center is to understand how normal cells undergo complex changes leading to cancer.

A man in a white coat works at a laboratory bench.

The scientific objectives of the MOO program are to elucidate the deregulated genetic and epigenetic events that drive tumor initiation and progression and develop new cancer targeting strategies.

The research aims focus on identifying and characterizing genetic and epigenetic alterations, elucidating the role of noncoding RNAs in cancer, studying oncogenic mechanisms of DNA tumor viruses, and translating MOO discovery to novel therapeutic approaches.

Aims

The aims of the MOO program are to elucidate the role of genetic and epigenetic alterations in cancer; define the role of regulatory microRNAs and long noncoding RNAs in oncogenesis; and translate MOO discoveries into novel therapeutic approaches.

Program Members

To request an update, please email ResearchDevelopment@cancer.ufl.edu.

NamemyNCBIResearch ProgramTitleDepartmentLab PageCollegeResearch Topic Interest
Bacher, Rhonda, PhD
Bacher, Rhonda, PhD
myNCBIMOOAssistant ProfessorDepartment of BiostatisticsCollege of Public Health and Health ProfessionsBioinformatics; Biostatistics
Baer, Charles F, PhD
Baer, Charles F, PhD
MOOProfessorDepartment of BiologyCollege of Liberal Arts and SciencesPopulation Genetics; Quantitative Genetics; Evolutionary Biology
Bennett, Richard L, PhD
Bennett, Richard L, PhD
myNCBIMOOResearch Associate ProfessorDepartment of MedicineCollege of MedicinePost-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; Apoptosis & Cell Death Pathways; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Leukemia; Lymphoma
Bhaduri-McIntosh, Sumita, MD, PhD
Bhaduri-McIntosh, Sumita, MD, PhD
MOOAssociate ProfessorDepartment of PediatricsCollege of MedicineTumor Virology/Virus-Host Interactions; Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Bloom, David C, PhD
Bloom, David C, PhD
MOOProfessorDepartment of Molecular Genetics and MicrobiologyCollege of MedicineTumor Virology/Virus-Host Interactions; Epigenetics & Cancer; Oncolytic Viral Vectors
Brant, Jason, PhD
Brant, Jason, PhD
MOOResearch Assistant ProfessorDepartment of Pathology, Immunology and Laboratory MedicineCollege of MedicineBioinformatics; Epigenetics & Cancer; Epigenetics & Gene Regulation
Bungert, Jorg, PhD
Bungert, Jorg, PhD
myNCBIMOOProfessorDepartment of Biochemistry and Molecular BiologyLabCollege of MedicineEpigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Butler, Jason, PhD
Butler, Jason, PhD
MOOProfessorDepartment of MedicineCollege of MedicineAngiogenesis; Cell Signaling Pathways; Chemotherapy; DNA Damage & Repair; Hematologic Malignancies/Blood & Marrow Transplant; Stem Cell; Vascular Targeting
Caglayan, Melike, PhD
Caglayan, Melike, PhD
myNCBIMOOAssistant ProfessorDepartment of Biochemistry and Molecular BiologyLabCollege of MedicineChemotherapy; DNA Damage & Repair; DNA Replication; Drug Design
Carroll, Kate, PhD
Carroll, Kate, PhD
MOOProfessorDepartment of Scripps Biomedical ResearchCollege of MedicineCell Signaling Pathways; Drug Design
Chang, Jia, PhD, DDS
Chang, Jia, PhD, DDS
myNCBIMOOAssistant ProfessorDepartment of PeriodontologyCollege of DentistryBone & Soft Tissue (Sarcoma); Bioinformatics; Post-Transcriptional Gene Regulation; Stem Cell; Biostatistics; Angiogenesis
Chen, Li, PhD
Li Chen
MOOAssociate ProfessorDepartment of BiostatisticsCollege of Public Health and Health ProfessionsBioinformatics; Biostatistics; Cancer Genetics; Cancer Information; Epigenetics & Cancer; Epigenetics & Gene Regulation
Cleverson de Souza, DVM, MS, PhD, DACVP
Cleverson de Souza, DVM, MS, PhD, DACVP
myNCBIMOOAssociate ProfessorComparative, Diagnostic, & Population MedicineCollege of Veterinary MedicineImmunoregulation & Suppression; Immunotherapy; Leukemia; Lymphoma; Nanotechnology
Daaka, Yehia, PhD
Daaka, Yehia, PhD
myNCBIMOOProfessorDepartment of Anatomy and Cell BiologyCollege of MedicineAndrogen Receptors; Human Pathophysiology Receptors
Dalal, Mansi, MD
Dalal, Mansi, MD
myNCBIMOOClinical Assistant ProfessorDepartment of PediatricsCollege of MedicineEpigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma; Pediatric Oncology
Datta, Susmita, PhD
Datta, Susmita, PhD
myNCBIMOOProfessorDepartment of BiostatisticsCollege of Public Health and Health ProfessionsBioinformatics; RNA Processing
Eddy, Matthew, PhD
Eddy, Matthew, PhD
myNCBIMOOAssistant ProfessorDepartment of ChemistryCollege of Liberal Arts and SciencesChemical biology; G-protein-coupled receptors
Falzarano, Sara, MD, PhD
Falzarano, Sara, MD, PhD
MOOClinical Associate ProfessorDepartment of Pathology, Immunology and Laboratory MedicineCollege of MedicineCancer Genetics; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Genital-Urinary/Prostate; Kidney
Fan, Xiao, PhD
Fan, Xiao, PhD
myNCBIMOOAssistant ProfessorDepartment of Biomedical EngineeringLabCollege of EngineeringBioinformatics; Biostatistics; Cancer Genetics; Cancer Information; Cancer Susceptibility; Genetic Determinants of Cancer; Post-Transciptional Gene Reguation
Fredenburg, Kristianna , MD, PhD
Fredenburg, Kristianna , MD, PhD
myNCBIMOOAssistant ProfessorDepartment of Pathology, Immunology and Laboratory MedicineCollege of MedicineCancer Disparities; Head & Neck; MicroRNAs
Garrett, Timothy, PhD
Garrett, Timothy, PhD
myNCBIMOOAssociate ProfessorDepartment of Pathology & Laboratory MedicineCollege of MedicineBioinformatics; Breast; Cancer Surveillance; Genital-Urinary/Prostate; Kidney; Tumor Virology/Virus-Host Interactions
Gentry, Matthew, PhD
Gentry, Matthew, PhD
myNCBIMOOProfessorDepartment of Biochemistry and Molecular BiologyCollege of MedicineDrug Design; Environment; Epigenetics & Cancer; Health Disparities; Lung; Pediatric Oncology
Graim, Kiley, PhD
Graim, Kiley, PhD
myNCBIMOOAssistant ProfessorDepartment of Computer and Information Science and EngineeringCollege of EngineeringBioinformatics; Genetic Determinants of Cancer
Griffin, Patrick, PhD
Griffin, Patrick, PhD
myNCBIMOOProfessorDepartment of Scripps Biomedical ResearchCollege of MedicineBreast; Drug Design
Guryanova, Olga, MD, PhD
Guryanova, Olga, MD, PhD
myNCBIMOOAssistant ProfessorDepartment of Pharmacology and TherapeuticsCollege of MedicineStem Cell; Cancer Genetics; Cancer Susceptibility; Cell Signaling Pathways; DNA Damage & Repair; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia
Huang, Shuang, PhD
Huang, Shuang, PhD
myNCBIMOOProfessorDepartment of Anatomy and Cell BiologyCollege of MedicineRNA Processing; Breast; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Gene Regulation; Gynecological; Metastasis; MicroRNAs
Ishov, Alexander M, PhD
Ishov, Alexander M, PhD
myNCBIMOOAssociate ProfessorDepartment of Anatomy and Cell BiologyCollege of MedicineProstate Cancer; Breast; Cancer Genetics; Chemotherapy; Epigenetics & Cancer
Jain, Piyush, PhD
Jain, Piyush, PhD
myNCBIMOOAssistant ProfessorDepartment of Chemical EngineeringLabCollege of EngineeringRNA Processing; Targeted Cancer Therapy; DNA Recombination; Cancer Genetics; DNA Damage & Repair; DNA Replication; Epigenetics & Cancer; Epigenetics & Gene Regulation; Gene Therapy; Nanotechnology; Noninvasive Imaging/Tomography
Katrin Karbstein, PhD
Katrin Karbstein, PhD
myNCBIMOOProfessorDepartment of Integrative Structural and Computational BiologyCollege of MedicineMolecular Chaperones; Post-Transcriptional Gene Regulation; RNA Processing
Kladde, Michael P, PhD
Kladde, Michael P, PhD
myNCBIMOOProfessorDepartment of Biochemistry and Molecular BiologyLabCollege of MedicineCancer Epigenetics; Cell Signaling Pathways; Colorectal and Breast Cancer; Glioblastoma
Kolb, Ryan, PhD
Kolb, Ryan, PhD
myNCBIMOOAssistant ProfessorDepartment of Pathology, Immunology and Laboratory MedicineCollege of MedicineTargeted Cancer Therapy; Vascular Targeting; Breast; Angiogenesis; Drug Resistance; Immunoregulation & Suppression; Immunotherapy; Kidney
Kondratov, Oleksandr, PhD
Kondratov, Oleksandr, PhD
myNCBIMOOResearch Assistant ProfessorDepartment of PediatricsCollege of MedicineEpigenetics & Cancer; Gene Therapy
Kotaro Fujii, PhD
Kotaro Fujii, PhD
myNCBIMOOAssistant ProfessorMolecular Genetics & MicrobiologyCollege of MedicinePost-Transcriptional Gene Regulation
Li, Chenglong, PhD
Li, Chenglong, PhD
MOOProfessorDepartment of Medicinal ChemistryCollege of PharmacyPediatric Oncology; Stem Cell; Targeted Cancer Therapy; Cell Signaling Pathways; Drug Design; Drug Resistance; Epigenetics & Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Neuro-Oncology
Li, Zhipeng, PhD
Li, Zhipeng, PhD
myNCBIMOOAssistant ProfessorDepartment of Biochemistry and Molecular BiologyCollege of MedicineApoptosis & Cell Death Pathways; Breast; Cancer Susceptibility; Drug Resistance; Genetic Determinants of Cancer
Liao, Daiqing , PhD
Liao, Daiqing , PhD
myNCBIMOOAssociate ProfessorDepartment of Anatomy and Cell BiologyCollege of MedicineTumor Virology/Virus-Host Interactions; Breast; Cancer Genetics; Cell Signaling Pathways; Chemotherapy; Drug Design; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genital-Urinary/Prostate; Apoptosis & Cell Death Pathways; Immunoregulation & Suppression
Licht, Jonathan D, MD
Licht, Jonathan D, MD
myNCBIMOOProfessorDepartment of MedicineLabCollege of MedicineDNA Damage & Repair; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Lu, Jianrong, PhD
Lu, Jianrong, PhD
myNCBIMOOAssociate ProfessorDepartment of Biochemistry and Molecular BiologyCollege of MedicinePost-Transcriptional Gene Regulation; Breast; Cancer Genetics; Cell Signaling Pathways; Angiogenesis; Epigenetics & Cancer; Epigenetics & Gene Regulation; Genetic Determinants of Cancer; Apoptosis & Cell Death Pathways; Metastasis
Ma, Zhe, PhD
Ma, Zhe, PhD
myNCBIMOOAssistant ProfessorDepartment of Molecular Genetics and MicrobiologyLabCollege of MedicineTumor Virology/Virus-Host Interactions
Maupin-Furlow, Julie, PhD
Maupin-Furlow, Julie, PhD
myNCBIMOOProfessorDepartment of Microbiology & Cell ScienceCollege of Agricultural and Life SciencesCell Signaling Pathways; Microbiology
McIntosh, Michael, PhD
McIntosh, Michael, PhD
myNCBIMOOAssociate ProfessorDepartment of PediatricsLabCollege of MedicineBioinformatics; Cancer Genetics; Cell Signaling Pathways; DNA Damage & Repair; Lymphoma; Tumor Virology/Virus-Host Interactions
McIntyre, Lauren, PhD
McIntyre, Lauren, PhD
myNCBIMOOProfessorDepartment of Molecular Genetics and MicrobiologyCollege of MedicineBioinformatics; Biostatistics; Cancer Genetics; Epigenetics & Gene Regulation; Nanotechnology; RNA Processing; Structural Virology
McKenna, Robert, PhD
McKenna, Robert, PhD
myNCBIMOOProfessorDepartment of Biochemistry and Molecular BiologyLabCollege of MedicineTargeted Cancer Therapy; Gene Therapy; Oncolytic Viral Vectors
Miller, Courtney, PhD
Miller, Courtney, PhD
myNCBIMOOProfessorDepartment of Scripps Biomedical ResearchCollege of MedicineHead & Neck; Neuro-Oncology
Moore, Helen, PhD
Moore, Helen, PhD
IOMAssociate ProfessorDepartment of Medicine College of MedicineCell Signaling Pathways; Chemotherapy; Hematologic Malignancies/Blood & Marrow Transplant; Immunoregulation & Suppression; Immunotherapy; Skin/Melanoma
Murfee, Walter, PhD
Murfee, Walter, PhD
MOOAssociate ProfessorDepartment of Biomedical EngineeringLabCollege of EngineeringStem Cell; Targeted Cancer Therapy; Vascular Targeting; Angiogenesis
Opavsky, Rene, PhD
Opavsky, Rene, PhD
myNCBIMOOAssociate ProfessorDepartment of Anatomy and Cell BiologyCollege of MedicineEpigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Leukemia; Lymphoma
Papp, Bernadett, PhD
Papp, Bernadett, PhD
myNCBIMOOAssistant ProfessorDepartment of Oral BiologyCollege of DentistryBioinformatics; Stem Cell; Tumor Virology/Virus-Host Interactions; Cell Signaling Pathways; Epigenetics & Cancer; Epigenetics & Gene Regulation
Perez, Alberto, PhD
Perez, Alberto, PhD
myNCBIMOOAssistant ProfessorDepartment of ChemistryLabCollege of Liberal Arts and SciencesBioinformatics; Epigenetics & Gene Regulation
Qian, Zhijian, PhD
Qian, Zhijian, PhD
MOOProfessorDepartment of MedicineCollege of MedicineStem Cell; Cancer Genetics; Cell Signaling Pathways; Drug Resistance; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant
Renne, Rolf F, PhD
Renne, Rolf F, PhD
myNCBIMOOProfessorDepartment of Molecular Genetics and MicrobiologyLabCollege of MedicineSkin/Melanoma; Tumor Virology/Virus-Host Interactions; Cell Signaling Pathways; Lymphoma; Noncoding RNAs
Schmittgen, Thomas, PhD
Schmittgen, Thomas, PhD
MOOProfessorDepartment of PharmaceuticsLabCollege of PharmacyCancer Genetics; Drug Design; Gastro-Intestinal; Head & Neck; Health Disparities; Liver; MicroRNAs; Nanotechnology
Srivastava, Arun, BSc, MSc, PhD
Srivastava, Arun, BSc, MSc, PhD
myNCBIMOOProfessorDepartment of PediatricsLabCollege of MedicineAAV Biology; Stem Cell; Targeted Cancer Therapy; Tumor Virology/Virus-Host Interactions; Gene Therapy; Liver
Tang, Xin, PhD
Tang, Xin, PhD
MOOAssistant ProfessorDepartment of Mechanical Aerospace EngineeringCollege of EngineeringVascular Targeting; Breast; Angiogenesis; Epigenetics & Cancer; Immunoregulation & Suppression; Immunotherapy; Integrative Medicine; Metastasis; Nanotechnology; Noninvasive Imaging/Tomography
Tibbetts, Scott, PhD
Tibbetts, Scott, PhD
myNCBIMOOProfessorDepartment of Molecular Genetics and MicrobiologyCollege of MedicineStem Cell; Tumor; Virology/Virus-Host Interactions; Epigenetics & Cancer; Epigenetics & Gene Regulation; Hematologic Malignancies/Blood & Marrow Transplant; Immunotherapy; Infection Control; Leukemia; Lymphoma; MicroRNAs; Noncoding RNAs
Toth, Zsolt, PhD
Toth, Zsolt, PhD
myNCBIMOOAssociate ProfessorDepartment of Oral BiologyCollege of DentistryPost-Transcriptional Gene Regulation; RNA Processing; Tumor Virology/Virus-Host Interactions; Cancer Genetics; Epigenetics & Gene Regulation; Immunoregulation & Suppression; Infection Control; Lymphoma
Vulpe, Christopher D, MD, PhD
Vulpe, Christopher D, MD, PhD
MOOProfessorDepartment of Physiological SciencesLabCollege of Veterinary MedicinePediatric Oncology; Precision Medicine; Synthetic Lethal Screens; Breast; Cancer Genetics; Chemotherapy; CRSPR; DNA Damage & Repair; Drug Resistance; Environment; Apoptosis & Cell Death Pathways; Leukemia
Wallace, Margaret R, PhD
Wallace, Margaret R, PhD
myNCBIMOOProfessorDepartment of Molecular Genetics and MicrobiologyCollege of MedicineSkin/Melanoma; Vascular Targeting; Biostatistics Bone & Soft Tissue Sarcomas; Breast; Cancer Genetics; DNA Damage & Repair; Epigenetics & Cancer; Genetic Determinants of Cancer; Head & Neck; Hematologic Malignancies/Blood & Marrow Transplant
Wang, Gary P, MD, PhD
Wang, Gary P, MD, PhD
MOOProfessorDepartment of MedicineCollege of MedicineBioinformatics; Gene Therapy; Liver
Wu, Lizi, PhD
Wu, Lizi, PhD
myNCBIMOOProfessorDepartment of Molecular Genetics and MicrobiologyCollege of MedicineCell Signaling; Oncogene; Tumor Suppressor; Noncoding RNA; Lung Cancer; Head and Neck Cancer; Leukemia; Mouse Tumor Model; Cancer Therapeutics
Xiao, Rui, PhD
Xiao, Rui, PhD
myNCBIMOOAssociate ProfessorDepartment of Aging and Geriatric ResearchCollege of MedicineSensory Modulation of Aging; Transcription Factors; Aging; Cellular Stress Response; Environmental Factors
Xie, Mingyi, PhD
Xie, Mingyi, PhD
myNCBIMOOAssociate ProfessorDepartment of Biochemistry and Molecular BiologyCollege of MedicineBioinformatics; RNA Processing; Tumor Virology/Virus-Host Interactions; Cancer Genetics; Cell Signaling Pathways; Epigenetics & Gene Regulation; MicroRNAs
Yan, Bowen PhD
Yan, Bowen PhD
myNCBIMOOResearch Assistant ProfessorDepartment of Pharmacology and TherapeuticsCollege of MedicineHematologic Malignancies; Blood & Marrow Transplant
Yin, Rui, PhD
Yin, Rui, PhD
myNCBIMOOAssistant ProfessorDepartment of Health Outcomes and Biomedical InformaticsCollege of MedicineBioinformatics; Cancer Genetics; Drug Design; Genetic Determinants of Cancer; Health Disparities; MicroRNAs, Tumor Virology/Virus-Host Interactions
Zolotukhin, Sergei, PhD
Zolotukhin, Sergei, PhD
MOOProfessorDepartment of PediatricsCollege of MedicineAAV Biology; Cancer Gene Therapy
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