Julie Bray
Faculty Research Mentor: Thomas Schmittgen, Ph.D.
My research focuses on the role of cell identity during the initial events of pancreatic cancer development. We believe that by defining and understanding the mechanism of pancreatic transdifferentiation, a putative therapeutic window may be opened for pancreatic cancer prevention and/or treatment.
Ozlem Calbay
Faculty Research Mentor: Shuang Huang, Ph.D.
My work focuses specifically on the elucidation of the underlying biological mechanism of ovarian cancer tumor progression and metastasis. The main goal of my research is to identify a possible prognostic indicators as future targets for therapy.
Chandler Callaway
Faculty Research Mentor: Andrew Judge, Ph.D.
Cancer cachexia is a metabolic syndrome that affects the majority of cancer patients. My current work focuses on identifying novel tumor-derived factors and pathways that may be causative in cancer cachexia.
Peter Dib
Faculty Research Mentor: Maria Zajac-Kaye, Ph.D.
My research focuses on understanding the mechanism of how thymidylate synthase (TS), a metabolic enzyme essential for both nucleotide biosynthesis and folate mediated one carbon metabolism, enhances tumorigenesis in lymphoma and sarcoma, and designing a new TS inhibition strategy. Our newly developed allosteric inhibitors of TS inhibit TS catalytic activity and slow down tumor cell growth in vitro and in vivo without inducing TS protein levels.
Zuo Ding
Faculty Research Mentor: Shuang Huang, Ph.D.
The Huang Lab previously discovered that SHOX2, a member of homeobox protein family, plays a significant role in breast cancer metastasis. My current research interest is to identify potential mechanisms that regulate cellular abundance of SHOX2.
Michael Dougherty
Faculty Research Mentor: Christian Jobin, Ph.D.
My project focuses on elucidating a role for the pks enzyme ClbS, which is encoded in the pks cluster and phenotypically confers colibactin resistance through an unknown mechanism. Clarifying a role for ClbS in cytotoxin resistance may inform strategies to inhibit pks+ E. coli-associated colorectal cancer and provide insight into the functional roles of cyclomodulins in tumorigenesis.
Henrietta Fasanya
Faculty Research Mentor: Dietmar Siemann, Ph.D.
My research project evaluates the role of a family of proteolytic enzymes, called cathepsins, that significantly contributes to the tumor cell migration and invasion. We hypothesize that inhibition of cathepsins will significantly decrease osteosarcoma metastasis in preclinical models.
Patrick Kellish
Faculty Research Mentor: Maria Zajac-Kaye, Ph.D.
My research focuses on the disease progression and immune evasion of small cell lung cancer (SCLC), and developing a combinational immunotherapy for SCLC. Our combination immunotherapy utilizes an oncolytic virus that selectively targets tumor cells in combination with targeting inhibitory immune molecules to stimulate anti-tumor immune responses.
Tianqi Li
Faculty Research Mentor: Mingyi Xie, Ph.D.
The Integrator complex has been identified as a key regulator of RNA polymerase II mediated transcription with the processing of small nuclear RNAs(snRNA). There is relatively little known about the function of Integrator, how it controls RNA metabolism and how these RNAs operate within cells. My current work focuses on identifying the subunit of Integrator complex crosslink the RNA of interest.
Rachel Newsome
Faculty Research Mentor: Christian Jobin, Ph.D.
My research currently focuses on host-microbe interactions in regards to inflammation and cancer. I use bacteria, mice and zebrafish models in conjunction with sequencing, gavage, injections, immunohistochemistry, and qPCR to study the immune response to intestinal microbes and the role of bacteria in cancer immunotherapy treatment.
Rachel Nosacka
Faculty Research Mentor: Andrew Judge, Ph.D.
My work is focused on understanding the intramuscular molecular pathways responsible for patients, with a specific focus on the Fox01-FoxP1-SRF axis, in order to contribute to the future development of muscle mass-preserving therapies for cancer patients.
Gabriel Prado
Faculty Research Mentor: Jonathan Licht, M.D.
Oncogenic Ras mutations have been shown to alter the chromatin landscape, at both enhancers and promoters. My research revolves around understanding the changes in KMT2C (a major H3K4me1 methyltransferase) expression within an oncogenic Ras background, and the potential synergy between KMT2C & Ras mutations in Acute Myeloid Leukemia (AML).
Mai Tanaka
Faculty Research Mentor: Dietmar Siemann, Ph.D.
My work focuses on understanding the Gas6/Axl signaling pathway that is dysregulated in many cancers and promotes metastatic phenotype. We believe that this signaling pathway is a promising therapeutic target to inhibit the dissemination of cells and to ultimately reduce cancer mortality.
Vrunda Trivedi
Faculty Research Mentor: Duane Mitchell, M.D., Ph.D.
My research is to identify tumor associated antigens and neoantigens in glioblastoma models and use them to generate a cytotoxic immune response against the tumor. I am also working on developing a novel T cell engineering based immunotherapy approach to improve the function of effector T cells in context of anti-tumor responses.
Kartika Venugopal
Faculty Research Mentor: Olga Guraynova, M.D., Ph.D.
My project investigates the efficacy of DNA replication targeting drugs in Acute Myeloid Leukemia with DNMT3A.
Vindhya Vijay
Faculty Research Mentor: Christopher Cogle, M.D.
My work focuses on understanding the effect of aberrant alternative splicing in cancers and a potential mechanism by which modulating splicing of key transcripts can lead to disease regression.
Aaron Waddell
Faculty Research Mentor: Daiqing Liao, Ph.D.
CBP/p300 are highly related acetyltransferases that acetylate chromatin and serve as co-activators for genes involved in cancer. We are using molecular, cellular and chemical biological approaches to understand roles in CBP/p300 in cancer biology and to devlop small molecule inhibitors of CBP/p300 enzymatic activity for cancer therapy.
Zachary Wakefield
Faculty Research Mentor: Dietmar Siemann, Ph.D.
My research focuses on how aerobic exercise can modulate the tumor microenvironment and host physiology to produce more favorable outcomes in cancer patients. Tumor progression, response to therapy, metastasis, and therapeutic toxicity are actively being investigated in the context of aerobic exercise.
Qin Yu
Faculty Research Mentor: Christian Jobin, Ph.D.
My research focuses on understanding host-microbe interactions and their role in pancreatic cancer development and treatment. We found that gut microbiota could accelerate pancreatic cancer progression in pre-clinical murine models. We believe that modulating gut microbiota could potentially be beneficial for pancreatic cancer treatment.
Xin Zhou
Faculty Research Mentor: Lizi Wu, Ph.D.
The tumor suppressor gene LKB1 is frequently inactivated and results in constitutive activation of CRTC/CREB signaling in non-small cell lung carcinomas. My research focuses on understanding the general role of CRTC activation and developing peptide-based inhibitor to block CRTC/CREB signaling pathway in LKB1 inactivated lung cancer.
Congratulations to our 2018-2019 Graduates!
Amani Harrandah (Graduated January 2019)
Faculty Research Mentor: Edward Chan, Ph.D.
Dissertation Project Title: Exploring the Roles of MicroRNA and Oral Bacteria in Oral Carcinogenesis
Current Position: Assistant Professor, Department of Oral Biology, Umm Alqura University
Yue Jiang (Graduated April 2019)
Faculty Research Mentor: Frederic Kaye, M.D.
Dissertation Project Title: Myb-activated tumor models for the development of novel therapeutic strategies for adenoid cystic carcinoma treatment
Current Position: Currently seeking a postdoctoral position
Mam Mboge (Graduated October 2018)
Faculty Research Mentor: Susan Frost, Ph.D.
Dissertation Project Title: The Role of Carbonic Anhydrase in Brease Cancer Growth, Metabolism, & Motility
Current Position: Postdoctoral Scholar, Berkeley National Laboratory
Varsha Sundaresan (Graduated November 2018)
Faculty Research Mentor: Lei Zhou, Ph.D.
Dissertation Project Title: Significantly Mutated Genes in Small Cell Lung Cancer & Comparative Analysis of p53 Binding
Current Position: Postdoctoral Fellow, University of Southern California